Study of Inflammatory Role of Epstein-Barr Virus (EBV) in Atrophic and Erosive Forms of Oral Lichen Planus

NCT ID: NCT02276573

Last Updated: 2023-11-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

13 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-03-30

Study Completion Date

2016-03-10

Brief Summary

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Oral lichen planus (OLP) is a chronic inflammatory and relapsing. The average prevalence is 1 to 4%. The clinics forms are many and symptoms are varied. The erosive form, painful and debilitating is characterized by erosive areas, ulcerated on an erythematous base with or without a keratinocyte lichenien network.

The literature data moving towards an autoimmune origin, but the pathophysiological mechanisms of OLP remain unknown.

This project represents the first part of a comprehensive project to examine the oral pathogenesis of different viruses (Herpes and papillomavirus HPV) and centered on Epstein-Barr Virus (EBV).

Detailed Description

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Conditions

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Lichen Planus, Oral

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Oral lichen planus disease

buccal cavity sample

Group Type EXPERIMENTAL

buccal cavity sample

Intervention Type BIOLOGICAL

Interventions

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buccal cavity sample

Intervention Type BIOLOGICAL

Eligibility Criteria

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Inclusion Criteria

* Patient ≥ 18 years
* Clinical and/or histological diagnosis of erosive or atrophic OLP
* No signs of severe dysplasia at the sampling

Exclusion Criteria

o immunosuppressive or anti-inflammatory therapies at the inclusion
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Centre Hospitalier Universitaire de Nice

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Hôpital saint Roch

Nice, , France

Site Status

Countries

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France

References

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Raybaud H, Olivieri CV, Lupi-Pegurier L, Pagnotta S, Marsault R, Cardot-Leccia N, Doglio A. Epstein-Barr Virus-Infected Plasma Cells Infiltrate Erosive Oral Lichen Planus. J Dent Res. 2018 Dec;97(13):1494-1500. doi: 10.1177/0022034518788282. Epub 2018 Jul 13.

Reference Type DERIVED
PMID: 30004820 (View on PubMed)

Other Identifiers

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14-AOI-02

Identifier Type: -

Identifier Source: org_study_id

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