Study of Metronidazole and Doxycycline to Treat Oral Lichen Planus and to Compare Their Efficacy With Each Other

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

20 participants

Study Classification

INTERVENTIONAL

Study Start Date

2005-09-30

Study Completion Date

2006-05-31

Brief Summary

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Oral lichen planus (OLP) is a chronic inflammatory disorder which causes local irritation,discomfort and subsequent poor dentition and discomfort in eating . Various treatments have been suggested for OLP but their results are unsatisfactory .Despite the fact that steroids have been the main therapeutic choice for many years,some researches have been done regarding the efficacy of other medication such as metronidazole and doxycycline.The purpose of this study is to determine whether metronidazole and doxycycline are effective in the treatment of oral lichen planus and to compare their efficacy with each other.

Detailed Description

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Conditions

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Oral Lichen Planus

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Interventions

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metronidazole,doxycycline

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* a biopsy-proven untreated OLP of every type with no symptom.

Exclusion Criteria

* pregnancy, presence of dysplasia in lesions,unilateral lesion suspected lichenoid reaction,history of drinking alcohol in at least 1 month prior to the study, smoking, systemic disease, use of systemic medications and hypersensitivity to the metronidazole and doxycycline.

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Principal Investigators

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Arash Mansourian, DDS,MS

Role: STUDY_CHAIR

Tehran University of Medical Sciences

Majid Sanatkhani, DDS,MS

Role: STUDY_DIRECTOR

Mashhad University of Medical Sciences

Fatemeh Momen Heravi

Role: PRINCIPAL_INVESTIGATOR

Tehran University of Medical Sciences

Locations

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Mashhad University Of Medical Sciences(Dentistry School)

Mashhad, Khorasan, Iran

Site Status

Countries

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Iran

Other Identifiers

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240

Identifier Type: -

Identifier Source: org_study_id