Hand Acceleration Time Assessment With Ultrasound Doppler

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

ACTIVE_NOT_RECRUITING

Total Enrollment

35 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-06-01

Study Completion Date

2024-04-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Chronic upper limb ischemia syndrome is uncommon compared to lower limb ischemia, with several potential causes (e.g., arteriosclerosis, compressive syndromes, arteritis, connective tissue diseases, trauma, and thrombosis). Many patients with upper limb ischemia remain asymptomatic due to arterial collateral vascularization.

Given the wide variety of potential causes for upper limb ischemia, the diagnosis may require different technical approaches. Doppler ultrasound is a non-invasive, accessible, non-radiating technique that provides direct arterial imaging, yielding valuable information on arterial anatomy and hemodynamics.

Some authors have described the reliability of the arterial duplex ultrasound for lower limb assessment using the pedal acceleration time (PAT). The PAT provides real-time hemodynamic physiological information on the entire limb. The acceleration time (AT) is an ultrasound parameter which measures the time elapsed (in milliseconds, ms) from the beginning of the arterial Doppler waveform until the systolic peak, evaluating the morphology of the arterial waveform in real time. In a healthy individual, this time should be short (between 40 - 100 milliseconds), displaying a triphasic waveform with a systolic acceleration, a sudden diastolic fall, and a subsequent anterograde flow at the end of diastole. A more damped wave suggests proximal stenosis and the acceleration time has been correlated to different degrees of foot ischemia.

Notably, the AT parameter has also been studied in other territories, such as the carotid and pulmonary arteries, coronary arteries, and the aorta. Hand acceleration time (HAT) has also been described very recently as a potential tool to assess hemodialysis access-induced ischemia, cardiogenic shock, and subclavian iatrogenic ischemic lesion. However, the HAT has not yet been properly characterized or validated. Our working hypothesis is that the HAT is a useful diagnostic tool for chronic upper limb ischemia.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Hand Acceleration Time (HAT) Assessment Before and After Creating an Arteriovenous Fistula (AVF)

NCT06187207

Arteriovenous Fistula Vascular Diseases

RECRUITING

Evaluation of Macro and Microcirculatory Arterial Condition of the Upper Limb in Insufficiently Renal Patients

NCT04451018

Arteriopathy Upper Limb Renal Insufficiency Digital Pressure

UNKNOWN

Synovial Proliferation on Routine Ultrasound: Active or Inactive?

NCT06809972

Haemophilia Hemophilia A Hemophilia B

NOT_YET_RECRUITING

Relationship Between Arterial Variations and Patency of Arteriovenous Fistulae

NCT04613115

Arteriovenous Fistula Ultrasound Artery

COMPLETED

Ultrasonic Perfusion Estimation in Calf Muscle

NCT04755335

Peripheral Arterial Disease

COMPLETED

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Upper Limb Ischemia Vascular Disease

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

OTHER

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Healthy Volunteers

Lack of upper limb arterial disease.

Hand Doppler Ultrasound

Intervention Type DIAGNOSTIC_TEST

Hand Doppler Ultrasound to assess the Hand Acceleration Time (HAT)

Patients with Chronic Upper Limb Ischemia

Known diagnosis of chronic upper limb ischemia.

Hand Doppler Ultrasound

Intervention Type DIAGNOSTIC_TEST

Hand Doppler Ultrasound to assess the Hand Acceleration Time (HAT)

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Hand Doppler Ultrasound

Hand Doppler Ultrasound to assess the Hand Acceleration Time (HAT)

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Healthy adult volunteers (≥ 18 years of age).
* No evidence of upper limb arterial disease.
* Who sign the written informed consent.

* Adult patients (≥ 18 years of age) with a known diagnosis of chronic upper limb ischemia.
* Who sign the written informed consent.

Exclusion Criteria

* Healthy volunteers unable (at the investigator discretion) to understand or comply with any study-related procedure.
* Healthy volunteers who refuse to participate.
* Those presenting cardiovascular risk factors (e.g., hypertension, diabetes mellitus, dyslipidemia).

* Patients unable (at the investigator discretion) to understand or comply with any study-related procedure.
* Patients who refuse to participate.

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes