Effect of Tadalafil, Sildenafil and Pentoxyfylline on Frozen Embryo Transfer Outcomes

NCT ID: NCT05971667

Last Updated: 2023-08-03

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

PHASE2/PHASE3

Total Enrollment

200 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-07-30

Study Completion Date

2023-10-30

Brief Summary

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The aim of this study is to investigate the Effect of different vasodilators as Tadalafil, Sildenafil and pentoxyfylline in In vitro Fertilization. In addition, the thickness of endometrium and pregnancies rates of these women will also be examined. All adverse effects of all drugs will be estimated

Detailed Description

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A prospective randomized clinical study will be conducted in the IVF clinic of the gynecology department of Beni Suef University Hospital, Beni-Suef, Egypt. The study will These patients will be randomized into four groups.

The participants will take drugs starting from the end of menstruation cycle till endometrium reach optimal and then will start progesterone 800 mg daily.

Conditions

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IVF

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Participants

Study Groups

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tadalafil

tadalafil 10 mg one tablet daily

Group Type EXPERIMENTAL

tadalafil

Intervention Type DRUG

tadalafil 10 mg one tablet daily

pentoxifylline

pentoxyfilline 400 mg two tabs daily

Group Type EXPERIMENTAL

pentoxifylline

Intervention Type DRUG

pentoxifylline 400 mg two tabs daily

sildenafil

sildenafil 20 mg two tablets

Group Type EXPERIMENTAL

Sildenafil

Intervention Type DRUG

sildenafil 20 mg two tablets daily

control group.

no intervention is given

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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tadalafil

tadalafil 10 mg one tablet daily

Intervention Type DRUG

Sildenafil

sildenafil 20 mg two tablets daily

Intervention Type DRUG

pentoxifylline

pentoxifylline 400 mg two tabs daily

Intervention Type DRUG

Other Intervention Names

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cialong Respatio trental

Eligibility Criteria

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Inclusion Criteria

* women having thawed embryos

Exclusion Criteria

* hypotension
* cardiovascular, hepatic, and renal diseases;
* uncontrolled diabetes mellitus;
* ovarian cysts;
* hyperprolactinemia;
* abnormal thyroid functions;
* uterine fibroids;
* patients taking nitrates;
* endometriosis and adenomyosis
Minimum Eligible Age

20 Years

Maximum Eligible Age

40 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Beni-Suef University

OTHER

Sponsor Role lead

Responsible Party

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Sara Abdallah Mohamed Salem

Lecturer of Gynecology and obstetrics Faculty of medicine Beni-Suef University

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Beni-suef university Hospital

Banī Suwayf, Beni Suweif Governorate, Egypt

Site Status

Countries

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Egypt

Other Identifiers

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Tadalafil IVF

Identifier Type: -

Identifier Source: org_study_id

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