Treatment Chronic UTI Post Kidney Transplant

NCT ID: NCT05967130

Last Updated: 2025-06-10

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

PHASE3

Total Enrollment

5 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-07-01

Study Completion Date

2024-07-01

Brief Summary

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Urinary tract infections (UTIs) with extended-spectrum -lactamase (ESBL)-positive Enterobacteriums (ESBL-E) are a common infectious complication of renal transplant recipients, with 10% of patients suffering from UTIs with ESBL-E within the first year posttransplant. Moreover, recurrence rates of UTI caused by ESBL-E are almost three times higher than those by cephalosporin-susceptible Enterobacteriums demonstrating the decreased efficacy of antibiotics in the treatment of these UTIs.

Detailed Description

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According to each patient's urine culture, resistant urinary tract infections will be treated with specific phages and patients will be followed up with their urine cultures for response to therapy.

Conditions

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Urinary Tract Infections Transplant-Related Disorder

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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UC Positives

Stable Transplanted Patients with Positive UC

Group Type EXPERIMENTAL

Phage

Intervention Type BIOLOGICAL

Inserting specific specimen of phages in to the bladder

Interventions

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Phage

Inserting specific specimen of phages in to the bladder

Intervention Type BIOLOGICAL

Eligibility Criteria

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Inclusion Criteria

* Stable Kidney Transplant Recipients
* Stable Immunosupression Dose
* Stable Renal Function
* Resistant Urinary Infection with Positive UC

Exclusion Criteria

* Rejection periods
* Frail Patients
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Shahid Beheshti University of Medical Sciences

OTHER

Sponsor Role lead

Responsible Party

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nooshin dalili

Assistant Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Dalili

Role: PRINCIPAL_INVESTIGATOR

SBMU

Locations

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Nooshin Dalili

Tehran, , Iran

Site Status

Countries

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Iran

Other Identifiers

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SBMU-

Identifier Type: -

Identifier Source: org_study_id

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