Influence of Persistent Food Allergy on Nutritional Status of Children With Food Allergy
NCT ID: NCT05937061
Last Updated: 2023-07-10
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
130 participants
OBSERVATIONAL
2019-05-01
2022-12-31
Brief Summary
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The main question\[s\] it aims to answer are:
* If children with food allergy groups will have lower food intake od micronutrients?
* If growth in children with food allergy is worse as in control group?
* If they are more malnourished and in the food allergies group is more stunting than in the control group?
* If children with milk allergy have lower intake of calcium in their diet and lower mineral bone density?
Participants will be asked to do 3 day food diary and to have blood analysed (hemograme, complete blood count, serum iron status, serum protein).
If there is a comparison group: Researchers will compare milk, egg and peanut allergy group to the control group (peers without food allergy) to see if the food allergy affects growth, macronutrient, micronutrient intake.
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Detailed Description
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Conditions
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Study Design
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CASE_CONTROL
RETROSPECTIVE
Study Groups
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Milk allergy
Children with milk allergy.
Blood sample analysis
Analysis of complete blood count, hemogram, serum proteins, serum iron status (iron, transferin, ferritin). Group comparison - intervention vs. control.
Bone mineral density measurement (DXA)
Analysis of bone mineral density with DXA in patients with milk allegy. Analysis ordered by medical doctor.
Influence of food allergy on growth (intervention groups)
Gathering the data about of body height (cm), weight (kg) BMI (kg/m2) at the diagnosis of food allergy and comparison versus data at the enrollment in the study to asses growth.
Egg Allergy
Children with egg allergy
Blood sample analysis
Analysis of complete blood count, hemogram, serum proteins, serum iron status (iron, transferin, ferritin). Group comparison - intervention vs. control.
Anthropometrics measurement - at inclusion to the study (all groups).
Measurement of body height (cm), weight (kg) and calculating BMI (kg/m2). Group comparison - intervention vs. control.
Influence of food allergy on growth (intervention groups)
Gathering the data about of body height (cm), weight (kg) BMI (kg/m2) at the diagnosis of food allergy and comparison versus data at the enrollment in the study to asses growth.
Peanut allergy
Children with peanut allergy
Blood sample analysis
Analysis of complete blood count, hemogram, serum proteins, serum iron status (iron, transferin, ferritin). Group comparison - intervention vs. control.
Anthropometrics measurement - at inclusion to the study (all groups).
Measurement of body height (cm), weight (kg) and calculating BMI (kg/m2). Group comparison - intervention vs. control.
Influence of food allergy on growth (intervention groups)
Gathering the data about of body height (cm), weight (kg) BMI (kg/m2) at the diagnosis of food allergy and comparison versus data at the enrollment in the study to asses growth.
Control group
Patients withhout food allergy (bee venom or drug allergy).
Blood sample analysis
Analysis of complete blood count, hemogram, serum proteins, serum iron status (iron, transferin, ferritin). Group comparison - intervention vs. control.
Anthropometrics measurement - at inclusion to the study (all groups).
Measurement of body height (cm), weight (kg) and calculating BMI (kg/m2). Group comparison - intervention vs. control.
Interventions
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Blood sample analysis
Analysis of complete blood count, hemogram, serum proteins, serum iron status (iron, transferin, ferritin). Group comparison - intervention vs. control.
Anthropometrics measurement - at inclusion to the study (all groups).
Measurement of body height (cm), weight (kg) and calculating BMI (kg/m2). Group comparison - intervention vs. control.
Bone mineral density measurement (DXA)
Analysis of bone mineral density with DXA in patients with milk allegy. Analysis ordered by medical doctor.
Influence of food allergy on growth (intervention groups)
Gathering the data about of body height (cm), weight (kg) BMI (kg/m2) at the diagnosis of food allergy and comparison versus data at the enrollment in the study to asses growth.
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* vegetarian or vegan nutrition.
2 Years
12 Years
ALL
Yes
Sponsors
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University Medical Centre Ljubljana
OTHER
Responsible Party
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Principal Investigators
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Tadej Avcin, prof.
Role: STUDY_DIRECTOR
Head of Department of Clinical Immunology, Rheumatology and Allergology
Locations
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Universitiy Medical center Ljubljana, division for Pediatrics
Ljubljana, , Slovenia
Countries
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References
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Berni Canani R, Leone L, D'Auria E, Riva E, Nocerino R, Ruotolo S, Terrin G, Cosenza L, Di Costanzo M, Passariello A, Coruzzo A, Agostoni C, Giovannini M, Troncone R. The effects of dietary counseling on children with food allergy: a prospective, multicenter intervention study. J Acad Nutr Diet. 2014 Sep;114(9):1432-9. doi: 10.1016/j.jand.2014.03.018. Epub 2014 Jun 3.
Beck C, Koplin J, Dharmage S, Wake M, Gurrin L, McWilliam V, Tang M, Sun C, Foskey R, Allen KJ; HealthNuts Investigators. Persistent Food Allergy and Food Allergy Coexistent with Eczema Is Associated with Reduced Growth in the First 4 Years of Life. J Allergy Clin Immunol Pract. 2016 Mar-Apr;4(2):248-56.e3. doi: 10.1016/j.jaip.2015.08.009. Epub 2015 Oct 2.
Meyer R, De Koker C, Dziubak R, Godwin H, Dominguez-Ortega G, Chebar Lozinsky A, Skrapac AK, Gholmie Y, Reeve K, Shah N. The impact of the elimination diet on growth and nutrient intake in children with food protein induced gastrointestinal allergies. Clin Transl Allergy. 2016 Jul 14;6:25. doi: 10.1186/s13601-016-0115-x. eCollection 2016.
Mailhot G, Perrone V, Alos N, Dubois J, Delvin E, Paradis L, Des Roches A. Cow's Milk Allergy and Bone Mineral Density in Prepubertal Children. Pediatrics. 2016 May;137(5):e20151742. doi: 10.1542/peds.2015-1742.
Robbins KA, Wood RA, Keet CA. Milk allergy is associated with decreased growth in US children. J Allergy Clin Immunol. 2014 Dec;134(6):1466-1468.e6. doi: 10.1016/j.jaci.2014.08.037. Epub 2014 Oct 11. No abstract available.
Kim J, Kwon J, Noh G, Lee SS. The effects of elimination diet on nutritional status in subjects with atopic dermatitis. Nutr Res Pract. 2013 Dec;7(6):488-94. doi: 10.4162/nrp.2013.7.6.488. Epub 2013 Nov 29.
Other Identifiers
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20200133
Identifier Type: -
Identifier Source: org_study_id
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