Influence of Stress on Encoding and Prediction

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

106 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-03-02

Study Completion Date

2024-10-04

Brief Summary

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The purpose of this study is to investigate the neural mechanisms by which acute stress influences statistical learning and episodic encoding.

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Detailed Description

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This study aims to assess the neural and behavioral mechanisms by which acute stress modulates episodic encoding (which involves the trisynaptic pathway: entorhinal cortex, dentate gyrus, cornu ammonis \[CA\] 3, and CA 1) and statistical learning (monosynaptic pathway: entorhinal cortex, CA1) in humans.

Conditions

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Stress Learning, Spatial

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Acute Stress

Participants complete the socially evaluated cold pressor test (SECPT), a validated laboratory-based stress induction procedure involving submerging an arm in an ice bath

Group Type EXPERIMENTAL

Socially Evaluated Cold Pressor Test

Intervention Type BEHAVIORAL

The SECPT is a brief validated laboratory-based stress induction containing both physical and social elements

No Stress

Participants complete a matched condition with no stress-related exposure involving submerging an arm in warm water

Group Type ACTIVE_COMPARATOR

Control

Intervention Type BEHAVIORAL

This is matched to the SECPT but with warm instead of cold water

Interventions

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Socially Evaluated Cold Pressor Test

The SECPT is a brief validated laboratory-based stress induction containing both physical and social elements

Intervention Type BEHAVIORAL

Control

This is matched to the SECPT but with warm instead of cold water

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* 18-45 years old
* Fluent in English
* BMI 18-35

Exclusion Criteria

* Meeting current DSM-V criteria for any substance use disorder (except caffeine)
* Having current significant medical conditions or psychiatric symptoms requiring medication
* Current use of medications/drugs that interfere with physiological stress responses
* Peri and post-menopausal women, pregnant or lactating women, and those with hysterectomies
* Metal in body (for MRI safety) history will be assessed for female participants.

Minimum Eligible Age

18 Years

Maximum Eligible Age

45 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes