Emotion Regulation Dysfunctions in NSSI Adolescents in Naturalistic Contexts

NCT ID: NCT05907421

Last Updated: 2024-04-11

Basic Information

• Recruitment Status: RECRUITING
• Total Enrollment: 80 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2023-12-06
• Study Completion Date: 2027-06-30

Brief Summary

Nonsuicidal self-injury (NSSI) is defined as direct, deliberate bodily harm without suicidal intention. Recent studies indicate that prevalence rates are increasing worldwide, in particular under adolescents, indicating a growing public health issue. An impaired ability to regulate negative emotion has been suggested to play a potential role in NSSI behavior. Some recent interventions aim at improving dysfunctional emotion regulation via 'acceptance'. Acceptance represents an objective, nonreactive, nonjudgmental, and calming emotion regulation strategy, partly based on the philosophy of dialectical behavior therapy (DBT) that has been widely used in the clinical treatment of NSSI behaviors. The aim of the present functional magnetic resonance imaging (fMRI) study is to examine whether adolescents with NSSI can implement the acceptance strategy in naturalistic emotional contexts (immersive video clips) and whether they differ from healthy controls in terms of behavioral and neural effects. To this end, the investigators recruit one group of NSSI adolescents (n=40) and one healthy control group (n=40), to compare the subjective emotional experience as well as underlying neural activity as measured by blood oxygenation level-dependent (BOLD) fMRI. The investigators hypothesize that compared to HC, NSSI adolescents will experience stronger negative emotions and show dysregulated neural recruitment of brain systems engaged in emotional reactivity and regulations (e.g. limbic regions, default mode network, and frontal regions).

Conditions

Nonsuicidal Self Injury; Emotion Regulation

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: CROSS_SECTIONAL

Study Groups

NSSI

Acceptance mindset

Intervention Type: BEHAVIORAL

Brief training of acceptance versus emotional reactivity as emotion regulation strategy.

HC

Acceptance mindset

Intervention Type: BEHAVIORAL

Brief training of acceptance versus emotional reactivity as emotion regulation strategy.

Interventions

Acceptance mindset

Brief training of acceptance versus emotional reactivity as emotion regulation strategy.

Intervention Type: BEHAVIORAL

Eligibility Criteria

Inclusion Criteria

• 15-18 years
• right-handed
• normal or corrected normal visual acuity
• meet the proposed DSM-5 frequency criteria (e.g., ≥5 days of NSSI behaviors in the past year)

Exclusion Criteria

• diagnosis of borderline personality disorder, major depressive disorder, other psychiatric disorders, etc.
• high suicidal risk
• recent use of medications that can affect neural activity
• have received or are receiving Dialectical Behavior Therapy (DBT) other treatment for emotional problems within the past 6 months
• have a contraindication to MRI scanning (e.g., metal implants, claustrophobia or other conditions that make them inappropriate for MRI scanning)

• Minimum Eligible Age: 15 Years
• Maximum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

University of Electronic Science and Technology of China

OTHER

Sponsor Role: lead

Responsible Party

Benjamin Becker

Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Sichuan Provincial Center for Mental Health, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China

Chengdu, Sichuan, China

Site Status: RECRUITING

Countries

China

Central Contacts

Benjamin Becker

Role: CONTACT

ben_becker@gmx.de

+86.028-61830867

Facility Contacts

Lyuan Li

Role: primary

lly_psychology@163.com

Other Identifiers

BAM_lab_NSSI_01

Identifier Type: -

Identifier Source: org_study_id