Venlafaxine for Postoperative Pain of Laparoscopic Cholecystectomy

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

PHASE1/PHASE2

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-05-30

Study Completion Date

2024-01-30

Brief Summary

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Recent studies on the impact of perioperative venlafaxine for treatment of acute postoperative pain have yielded positive outcomes . The aim of the present study is to investigate the role of perioperative venlafaxine on the management of postoperative pain in patients undergoing LC.

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Detailed Description

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Conditions

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Laparoscopic Cholecystectomy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Outcome Assessors

Study Groups

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Laparoscopic Cholecystectomy

Group Type ACTIVE_COMPARATOR

Venlafaxine

Intervention Type DRUG

Patients scheduled for elective LC will receive 150 mg venlafaxine before surgery

Control

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

Patients scheduled for elective LC will receive placebo venlafaxine before surgery

Interventions

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Venlafaxine

Patients scheduled for elective LC will receive 150 mg venlafaxine before surgery

Intervention Type DRUG

Placebo

Patients scheduled for elective LC will receive placebo venlafaxine before surgery

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* 1\. Patients who are scheduled to undergo elective LC

Exclusion Criteria

1- Patients with acute pancreatitis 2. Patients undergoing chronic pain treatment 3. Patients who received analgesics or sedatives 24 h before scheduled surgery 3. Patients had alcohol or drug addiction 4. Severe hepatic and renal dysfunction 5. Previous allergic response to duloxetine 6. Pregnancy and lactation 7. Patients with communication problems, cognitive dysfunction, or psychological disorders

Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No