Neutrophil/Lymphocyte Ratio in Acute Pancreatitis

NCT ID: NCT05859633

Last Updated: 2023-05-16

Basic Information

• Recruitment Status: UNKNOWN
• Total Enrollment: 100 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2023-05-30
• Study Completion Date: 2023-12-31

Brief Summary

Acute pancreatitis (AP) is a disease characterized by dysfunction of pancreatic acinar cells, improper activation of trypsin, and subsequent destruction of pancreatic self-defense mechanisms, further exacerbating injury and damage of pancreatic cells. It is a rapidly developing inflammatory process of the pancreas, and the most common reasons are alcohol and gallstones.

Detailed Description

As one of the most common gastrointestinal diseases in hospitalized patients, the incidence of AP has gradually increased and is 4.9 to 73.4 cases per 100,000 people worldwide in the past few decades, imposing a heavy burden on the health system and leading to long-term hospitalization, most medical costs, and significant mortality.

Up to 10% to 20% of AP patients will develop SAP, and the leading cause of poor prognosis in patients with AP is a vital organ (cardiovascular organs, lung, and kidney) failure and pancreatic necrosis . In clinical practice, varieties of scoring systems are available and have been gradually confirmed, such as the Ranson score, Glasgow score, Acute Physiology and Chronic Health Evaluation (APACHE II), BISAP, and computed tomography severity index (CTSI) . These systems are cumbersome and take a long time to operate, requiring a lot of parameters that are not routinely collected in the early stages of the disease. For example, the BISAP score is characterized by high specificity, but its sensitivity to SAP is not satisfied. Therefore, their early prediction power is not good.

In AP, inflammation first activates a series of inflammatory cytokines, proteolytic enzymes, and anaerobic radioactive nucleic acids to destroy the tissue. The degree of neutrophils decrease is related to the improvement of prognosis of AP, while the degree of lymphocyte increase is related to the severity of the disease. The neutrophil-lymphocyte ratio (NLR) is a more comprehensive biomarker that used neutrophil and lymphocyte counts to respond rapidly to the extent of inflammatory progression and serves as a useful predictive marker to identify the severity of AP. It is well known that AP is a fast-onset inflammation of the pancreas, and an effective prediction of the severity of AP can guide AP patients to receive adequate treatment earlier, contributing to a better prognosis.

Conditions

Acute Pancreatitis

Study Design

• Observational Model Type: CASE_ONLY
• Study Time Perspective: PROSPECTIVE

Study Groups

patients with acute pancreatitis

any patient suffers from acute pancreatitis

Neutrophil/Lymphocyte Ratio in acute pancreatitis

Intervention Type: DIAGNOSTIC_TEST

role of Neutrophil/Lymphocyte Ratio in acute pancreatitis

Interventions

Neutrophil/Lymphocyte Ratio in acute pancreatitis

role of Neutrophil/Lymphocyte Ratio in acute pancreatitis

Intervention Type: DIAGNOSTIC_TEST

Eligibility Criteria

Inclusion Criteria

• patients with acute pancreatitis

Exclusion Criteria

• Patients with acute abdomen with diagnosis other than AP
• Patients with AP who are under age of 18 years old
• Patient's refusal

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Assiut University

OTHER

Sponsor Role: lead

Responsible Party

Romany Waheed Morkis Beshay

Internal Medicine

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Ahmed M Abu-Elfatth

Role: PRINCIPAL_INVESTIGATOR

Assiut University

Locations

Ahmed Mohammed Abu-Elfatth

Asyut, , Egypt

Site Status: RECRUITING

Countries

Egypt

Central Contacts

Ahmed M Abu-Elfatth

Role: CONTACT

ahmed111@aun.edu.eg

+18677791

Facility Contacts

Ahmed M Abu-Elfatth

Role: primary

ahmed111@aun.edu.eg

8677791

References

Mederos MA, Reber HA, Girgis MD. Acute Pancreatitis: A Review. JAMA. 2021 Jan 26;325(4):382-390. doi: 10.1001/jama.2020.20317.

Reference Type: BACKGROUND

PMID: 33496779 (View on PubMed)

Other Identifiers

Romay

Identifier Type: -

Identifier Source: org_study_id