Evaluation of the Effectiveness of Breathing Control Technique on Long COVID Symptoms at the Reunion University Hospital
NCT ID: NCT05851859
Last Updated: 2025-07-30
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
200 participants
INTERVENTIONAL
2025-05-05
2027-04-30
Brief Summary
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The Reunion Island is a French overseas department located in the Indian Ocean accounting more than 860,000 inhabitants. It has recorded since March 11, 2020, nearly 491,825 cases of COVID-19 and 961 deaths of hospitalized patients. Reunion's population is multi-ethnic and younger than the metropolitan France's one. It also has a higher prevalence of obesity and type 2 diabetes, two serious form factors of COVID-19. This specific context makes this island a particular study site for Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) and Long COVID.
In addition, some studies have confirmed the involvement of the autonomic nervous system (ANS) in the symptomatology of Long COVID and demonstrated that patients with a Long COVID present a dysfunction of their ANS which is objectified by a reduced Heart Rate Variability (HRV). The regulation of heart rate by the ANS is strongly favored by respiration. A regular slow and deep breathing training helps to adjust the baroreflex, which connect heart rate, breathing and blood pressure. The result of this training is an induced state called "cardiac coherence" (CC).
The investigator therefore hypothesize that respiratory training to CC could "re-educate" the ANS and durably improve the symptomatology of patients with Long COVID.
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
SINGLE
Study Groups
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Complementary respiratory training to cardiac coherence (CC)
The " intervention " group will benefit from a complementary respiratory training to CC during 6 months in addition to the usual care procedure.
Cardiac coherence
Use of Cardiac coherence (complementary respiratory training) during 6 month
Usual care procedure in the event of Long COVID
The " control " group will follow a usual care procedure in the event of Long COVID
No interventions assigned to this group
Interventions
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Cardiac coherence
Use of Cardiac coherence (complementary respiratory training) during 6 month
Eligibility Criteria
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Inclusion Criteria
* living in Reunion and
* having a diagnosis of Long COVID according to the World Health Organization (WHO) definition will be included in this study.
* These patients must attest to their primary infection with Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) and present a negative antigen test at the time of inclusion.
Exclusion Criteria
* with a chronic or disabling respiratory pathology preventing respiratory training (asthma, Chronic Obstructive Pulmonary Disease (COPD), active tuberculosis, pulmonary sequelae of COVID-19, etc.) practicing or having practiced a regular respiratory control technique (yoga, Cardiac coherence training, etc.) in the last 6 months
* taking a beta-blocker, betamimetic, anti-arrhythmic, morphine, antidepressant treatment (Escitalopram)
* having a pacemaker or severe heart disease
* Current and known pregnancy or breastfeeding woman
* with a cognitive deficit
* under guardianship/curators or under judicial protection
18 Years
ALL
No
Sponsors
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Centre Hospitalier Universitaire de la Réunion
OTHER
Responsible Party
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Locations
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CHU de la Réunion
Saint-Denis, , France
CHU de la Réunion
Saint-Pierre, , France
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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2023-A00796-39
Identifier Type: OTHER
Identifier Source: secondary_id
2022/CHU/35
Identifier Type: -
Identifier Source: org_study_id
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