Tympanoseal Clinical Study

NCT ID: NCT05849844

Last Updated: 2024-10-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

45 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-01-05

Study Completion Date

2026-04-20

Brief Summary

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The purpose of this investigational study is to assess the ability of Tympanoseal (sodium/calcium alginate), an investigational device, to act as a scaffold during healing of the tympanic membrane. Tympanoseal is intended for use following removal or extrusion of indwelling tympanostomy tubes or traumatic injury of the tympanic membrane.

Detailed Description

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This study will provide data on the safety and the ability of sodium/calcium alginate gels to act as a scaffold capable of occluding a tympanic membrane perforation over the duration of complete healing. Tympanoseal could be used in cases where cartilage or fat graft tympanoplasty would be indicated.

Conditions

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Tympanic Membrane Perforation

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Tympanoseal

All subjects will receive the Tympanoseal device that will be placed during a surgical procedure.

Group Type EXPERIMENTAL

Tympanoseal

Intervention Type DEVICE

All subjects will receive the Tympanoseal device that will be placed during a surgical procedure

Interventions

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Tympanoseal

All subjects will receive the Tympanoseal device that will be placed during a surgical procedure

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

1. Male or female patients over 2 years of age at enrollment
2. Documentation of a retained tympanostomy tube or perforation less than 5 mm not on the edge of the tympanic membrane.
3. Written informed consent (and assent when applicable) obtained from subject or subject's legal guardian and ability for subject to comply with the requirements of the study

Exclusion Criteria

1. Active otorrhea or otitis media
2. Otorrhea or otitis media within 4 weeks prior to the operation
3. History of cholesteatoma
4. Perforations on the edge of the tympanic membrane
5. Presence of a condition or abnormality that in the opinion of the Investigator would compromise the safety of the patient or the quality of the data
6. Subject is taking systemic/oral corticosteroids
7. Subject will require the continued use of any type of topical otic medication to the ear(s) with Tympanoseal
Minimum Eligible Age

2 Years

Maximum Eligible Age

100 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Grace Medical, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Michigan Ear Institute

Farmington Hills, Michigan, United States

Site Status RECRUITING

Methodist Le Bonheur

Memphis, Tennessee, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Robert Stroup

Role: CONTACT

901-386-0990

Facility Contacts

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Seilesh Babu, MD

Role: primary

248-865-4135

Robert Stroup

Role: backup

6623970553

Robert Yawn, MD

Role: primary

901-287-7337

Other Identifiers

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2022.01

Identifier Type: -

Identifier Source: org_study_id

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