Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
100 participants
OBSERVATIONAL
2023-06-30
2024-05-31
Brief Summary
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Detailed Description
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Tracheoesophageal fistula (TEF) represents one of the most common congenital anomalies seen in infants, Infants with TEF classically present with respiratory distress, feeding difficulties, choking, and risk for aspiration. TEF is most commonly associated with other congenital anomalies, particularly cardiac defects. Esophageal atresia (EA) is a related congenital malformation with a similar presentation to TEF and can occur with or without the presence of a fistula.
Although the events leading to separation of the primitive trachea and esophagus are not completely understood, the most commonly accepted hypothesis is that a defect in the lateral septation of the foregut into the trachea and esophagus causes TEF and EA.
The trachea and esophagus develop from a common primitive foregut, and at approximately 4 weeks of gestation, the developing respiratory and gastrointestinal tracts are separated by epithelial ridges. The foregut divides into a ventral respiratory tract and a dorsal esophageal tract; the fistula tract is thought to derive from an embryonic lung bud that fails to undergo branching. These defects of mesenchymal proliferation are thought to lead to TEF formation.
The incidence of TEF is approximately 1 in 3500 births. EA and TEF are classified according to their anatomic configuration.
Conditions
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Study Design
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CASE_CROSSOVER
CROSS_SECTIONAL
Interventions
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Tracheoesophageal fistula repair
Tracheoesophageal fistula repair
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Patients diagnosed with other diseases.
* Patients with acquired tracheoesophageal fistula.
28 Days
ALL
No
Sponsors
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Assiut University
OTHER
Responsible Party
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Assem Abd El-razek Elkateeb
Doctor
Central Contacts
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References
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Ma LJ, Xiao Y, Yang QW, Wang J. [Laryngotracheal resection and reconstruction for the treatment of acquired laryngotracheal stenosis]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2017 Oct 7;52(10):738-743. doi: 10.3760/cma.j.issn.1673-0860.2017.10.005. Chinese.
Cui PC, Luo JS, Liu Z, Bian K, Guo ZH, Ma RN. [Segmental tracheal resection and anastomosis for the treatment of cicatricial stenosis in cervical tracheal]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2016 Feb;51(2):95-9. doi: 10.3760/cma.j.issn.1673-0860.2016.02.004. Chinese.
Other Identifiers
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trachea-esophageal fistula
Identifier Type: -
Identifier Source: org_study_id
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