Tailored Pain Guide (TPG) Study

NCT ID: NCT05843890

Last Updated: 2025-04-01

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

550 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-08-18

Study Completion Date

2027-02-28

Brief Summary

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This research is studying whether changing an individual's behaviors may have an impact as a treatment or outcome for chronic low back pain. This research will try to understand how much an electronic, self-management website like PainGuide can help participants.

The study hypothesizes that tailored digital interventions (plus using PainGuide) will demonstrate greater improvement in pain interference.

Detailed Description

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There was an amendment approved by the University of Michigan Medical School Institutional Review Board (AME00158411). This amendment included the following:

increased enrollment numbers, updated recruitment procedures including the Non-Pharma Program (NPP) Sub-Study, as well as changes in time frames.

Conditions

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Chronic Lower Back Pain

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

The initial study enrolled 297 participants. Following the amendment (AME00158411) the study team will now enroll the non-pharma program to this project. The anticipated enrollment number was increased from 430 to 550.
Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Structured and tailored PainGuide

Group Type EXPERIMENTAL

Structured and tailored PainGuide

Intervention Type BEHAVIORAL

Participants will receive specific instruction to complete one module a week over the first 4 weeks. Participants will then receive tailored messaging using scores from the assessments completed during T1(baseline visit) from the PROMIS 29+2.

The initial group of participants (prior to AME00158411) will complete surveys for 24 weeks.

The NPP Participants will be asked to complete surveys for 52 weeks.

All participants will also be registered with a Fitbit device that is linked to the PainGuide to capture movement data (daily step counts).

Standard PainGuide

Group Type ACTIVE_COMPARATOR

Standard PainGuide

Intervention Type BEHAVIORAL

Participants in the control group will not receive any messaging once enrolled. The initial group of participants (prior to AME00158411) will complete surveys for 24 weeks.

The NPP Participants will be asked to complete surveys for 52 weeks.

All participants will also be registered with a Fitbit device that is linked to the PainGuide to capture movement data (daily step counts).

Interventions

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Structured and tailored PainGuide

Participants will receive specific instruction to complete one module a week over the first 4 weeks. Participants will then receive tailored messaging using scores from the assessments completed during T1(baseline visit) from the PROMIS 29+2.

The initial group of participants (prior to AME00158411) will complete surveys for 24 weeks.

The NPP Participants will be asked to complete surveys for 52 weeks.

All participants will also be registered with a Fitbit device that is linked to the PainGuide to capture movement data (daily step counts).

Intervention Type BEHAVIORAL

Standard PainGuide

Participants in the control group will not receive any messaging once enrolled. The initial group of participants (prior to AME00158411) will complete surveys for 24 weeks.

The NPP Participants will be asked to complete surveys for 52 weeks.

All participants will also be registered with a Fitbit device that is linked to the PainGuide to capture movement data (daily step counts).

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Chronic Lower Back pain (cLBP) defined by the National Institutes of Health (NIH) Task Force Report on Research Standards for Chronic Low Back Pain, (i.e., low back pain present at least six months, and present more than half of those days.)
* Individuals must have a score of greater or equal to (≥) 60 on PROMIS Pain Interference.
* Non-Pharma Sub-study:

1. Must be referred and currently on the waitlist for the NPP at the Back \& Pain Center (BPC)

Exclusion Criteria

* Current cancer related pain
* Diagnosis of autoimmune disease
* Unable to speak, write or read English
* Visual or hearing difficulties
* Pregnancy or breastfeeding
* Any other diseases or conditions that would make a patient unsuitable for study participation as determined by the site principal investigators.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Michigan

OTHER

Sponsor Role lead

Responsible Party

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Daniel Clauw, MD

Professor of Anesthesiology

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Daniel Clauw, MD

Role: PRINCIPAL_INVESTIGATOR

University of Michigan

Locations

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University of Michigan

Ann Arbor, Michigan, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Beth Banner

Role: CONTACT

734-998-5837

Sana Shaikh

Role: CONTACT

734-763-5226

Facility Contacts

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Beth Banner

Role: primary

734-998-5837

Other Identifiers

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HUM00214375

Identifier Type: -

Identifier Source: org_study_id

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