Study of Sacituzumab Govitecan Versus Treatment of Physician's Choice in Patients With Hormone Receptor-positive/Human Epidermal Growth Factor Receptor 2 Negative (HR+/HER2-) Metastatic Breast Cancer Who Have Received Endocrine Therapy

NCT ID: NCT05840211

Last Updated: 2025-10-03

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Clinical Phase

PHASE3

Total Enrollment

654 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-05-08

Study Completion Date

2028-04-30

Brief Summary

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The goal of this clinical study is to see if sacituzumab govitecan-hziy (SG) can improve life spans of people with HR+/HER2- metastatic breast cancer and their tumor does not grow or spread when compared to currently available standard treatments, such as paclitaxel, nab-paclitaxel or capecitabine. The primary objective is to compare the effect of SG relative to the treatment of physician's choice (TPC) on progression-free survival (PFS).

Detailed Description

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Conditions

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Locally Advanced or Unresectable Metastatic Breast Cancer Stage IV Breast Cancer

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Sacituzumab Govitecan-hziy (SG)

Participants will receive SG at a dose of 10 mg/kg infusion on Days 1 and 8 of a 21-day cycle.

Group Type EXPERIMENTAL

Sacituzumab Govitecan-hziy

Intervention Type DRUG

Administered intravenously

Treatment of Physician's Choice (TPC)

Participants will receive TPC determined prior to randomization to 1 of the 3 allowed regimens:

* paclitaxel 80 mg/m\^2 over 1 hour (± 10 minutes) on Days 1, 8, and 15 of a 28-day cycle.
* nab-Paclitaxel 100 mg/m\^2 over 30 minutes (± 10 minutes) on Days 1, 8, and 15 of a 28-day cycle.
* capecitabine at 1000-1250 mg/m\^2 twice daily for 2 weeks followed by a 1-week rest period of a 21-day cycle.

Group Type ACTIVE_COMPARATOR

Paclitaxel

Intervention Type DRUG

Administered intravenously

Nab-paclitaxel

Intervention Type DRUG

Administered intravenously

Capecitabine

Intervention Type DRUG

Administered orally

Interventions

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Sacituzumab Govitecan-hziy

Administered intravenously

Intervention Type DRUG

Paclitaxel

Administered intravenously

Intervention Type DRUG

Nab-paclitaxel

Administered intravenously

Intervention Type DRUG

Capecitabine

Administered orally

Intervention Type DRUG

Other Intervention Names

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Trodelvy™ GS-0132 IMMU-132 Taxol® Abraxane® Xeloda®

Eligibility Criteria

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Inclusion Criteria

* Able to understand and give written informed consent.
* Must have adequate tumor tissue sample preferably from locally recurrent or metastatic site.
* Documented evidence of HR+ metastatic breast cancer (mBC) confirmed with the most recently available tumor biopsy preferably from a locally recurrent or metastatic site.
* Documented evidence of HER2- status.
* Documented PD by computed tomography (CT) or magnetic resonance imaging during or after the most recent therapy per RECIST v1.1 criteria.
* Candidate for the first chemotherapy in the locally advanced or metastatic setting.
* Eligible for capecitabine, nab-paclitaxel, or paclitaxel.
* Individuals must have at least one of the following:

* Disease progression on at least 2 or more previous lines of endocrine therapy (ET) with or without a targeted therapy in the metastatic setting.

* Disease recurrence while on the first 24 months of starting adjuvant ET will be considered a line of therapy; these individuals will only require 1 line of ET in the metastatic setting.
* Disease progression within 6 months of starting first-line ET with or without a cyclin-dependent kinase (CDK) 4/6 inhibitor (if ineligible or if unable to access a CDK 4/6 inhibitor) in the metastatic setting.
* Disease recurrence while on the first 24 months of starting adjuvant ET with CDK 4/6 inhibitor and if the individual is no longer a candidate for additional ET in the metastatic setting.
* Individuals may have received prior targeted therapies, including but not limited to PARP inhibitors (for those with germline BRCA1 or BRCA2 mutations), phosphatidylinositol 3-kinase (PI3K) inhibitors (for those with PIK3CA mutations), or mammalian target of rapamycin (mTOR) inhibitors. However, individuals can no longer be candidates for additional endocrine treatment with or without targeted therapies.
* Individuals with HIV must be on antiretroviral therapy (ART) and have a well-controlled HIV infection/disease.
* Demonstrates adequate organ function.
* Male individuals and female individuals of childbearing potential who engage in heterosexual intercourse must agree to use protocol-specified method(s) of contraception.
* Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.

Exclusion Criteria

* Progressive disease within 6 months of completing (neo)adjuvant chemotherapy.
* Locally advanced metastatic breast cancer (mBC) (Stage IIIc) in individuals who are candidates for curative intent therapy at the time of study enrollment.
* Current enrollment in another clinical study and use of any investigational device or drug (drugs not marketed for any indication) either within 5 half-lives or 28 days prior to randomization, whichever is longer.

* Use of investigational drugs in the category of Selective Estrogen Receptor Degraders are acceptable if last dose was longer than 14 days prior to randomization.
* Received any prior treatment (including antibody-drug conjugate (ADC)) containing a chemotherapeutic agent targeting topoisomerase I.
* Received any prior treatment with a trophoblast cell-surface antigen 2 (Trop-2)-directed ADC.
* Have an active second malignancy.
* Have an active serious infection requiring antibiotics.
* Have active hepatitis B virus (HBV) or hepatitis C virus (HCV).
* Individuals positive for human immunodeficiency virus type 1/2 (HIV-1 or -2) with a history of Kaposi sarcoma and/or Multicentric Castleman Disease.
* Have a positive serum pregnancy test or are breastfeeding for individuals who are assigned female at birth.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Gilead Sciences

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Gilead Study Director

Role: STUDY_DIRECTOR

Gilead Sciences

Locations

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Ironwood Physicians P.C. dba Ironwood Cancer and Research Centers

Chandler, Arizona, United States

Site Status

Los Angeles Hematology Oncology Medical Group

Los Angeles, California, United States

Site Status

Stanford Cancer Institute

Palo Alto, California, United States

Site Status

University of California, San Francisco (UCSF) Helen Diller Family Comprehensive Cancer Center

San Francisco, California, United States

Site Status

Rocky Mountain Cancer Centers, LLP

Littleton, Colorado, United States

Site Status

Yale-New Haven Hospital-Yale Cancer Center

New Haven, Connecticut, United States

Site Status

Investigational Drug Services, AdventHealth Orlando

Altamonte Springs, Florida, United States

Site Status

Florida Cancer Specialists

Brooksville, Florida, United States

Site Status

Florida Cancer Specialist

Leesburg, Florida, United States

Site Status

Florida Cancer Specialist

St. Petersburg, Florida, United States

Site Status

Piedmont Cancer Institute

Atlanta, Georgia, United States

Site Status

Georgia Cancer Specialist - Annex

Atlanta, Georgia, United States

Site Status

Northwest Georgia Oncology Centers

Marietta, Georgia, United States

Site Status

The University of Kansas Hospital

Kansas City, Kansas, United States

Site Status

Hematology Oncology Clinic

Baton Rouge, Louisiana, United States

Site Status

Saint Luke's Cancer Institute

Kansas City, Missouri, United States

Site Status

David C. Pratt Cancer Center

St Louis, Missouri, United States

Site Status

Astera Cancer Care

East Brunswick, New Jersey, United States

Site Status

Rutgers Cancer Institute of New Jersey

New Brunswick, New Jersey, United States

Site Status

Memorial Sloan-Kettering Cancer Center (MSKCC) - New York

New York, New York, United States

Site Status

Cleveland Clinic

Cleveland, Ohio, United States

Site Status

Stefanie Spielman Comprehensive Breast Center

Columbus, Ohio, United States

Site Status

Penn State Cancer Institute

Hershey, Pennsylvania, United States

Site Status

Magee-Womens of UPMC

Pittsburgh, Pennsylvania, United States

Site Status

Prisma Health - Upstate

Greenville, South Carolina, United States

Site Status

Tennessee Oncology, PLLC

Nashville, Tennessee, United States

Site Status

Vanderbilt University Medical Center - Vanderbilt-Ingram Cancer Center

Nashville, Tennessee, United States

Site Status

US Oncology Investigational Products Center (IPC)

Fairfax, Virginia, United States

Site Status

US Oncology Investigational Products Center (IPC)

Norfolk, Virginia, United States

Site Status

MultiCare Regional Cancer Center - Auburn

Auburn, Washington, United States

Site Status

Hospital Britanico de Buenos Aires

Buenos Aires, , Argentina

Site Status

Instituto de Investigaciones Clinicas de Mar del Plata

Buenos Aires, , Argentina

Site Status

Instituto Alexander Fleming

C.a.b.a., , Argentina

Site Status

Hospital Alemán

CABA, , Argentina

Site Status

Centro Privado de RMI Rio Cuarto S.A.

Córdoba, , Argentina

Site Status

Instituto de Oncología de Rosario

Rosario, , Argentina

Site Status

CER San Juan Centro Polivalente de Asistencia e Investigación Clínica

San Juan, , Argentina

Site Status

Royal Brisbane and Women's Hospital

Queensland, ME, Australia

Site Status

St Vincent's Hospital Sydney

Darlinghurst, New South Wales, Australia

Site Status

Liverpool Hospital

Liverpool, New South Wales, Australia

Site Status

GenesisCare North Shore (Oncology)

St Leonards, New South Wales, Australia

Site Status

Icon Cancer Centre Wesley

Auchenflower, Queensland, Australia

Site Status

Flinders Medical Centre

Bedford Park, South Australia, Australia

Site Status

Icon Cancer Centre Hobart

Hobart, Tasmania, Australia

Site Status

Austin Health

Melbourne, Victoria, Australia

Site Status

Sunshine Hospital (Western Health)

St Albans, Victoria, Australia

Site Status

Breast Cancer Research Centre - WA

Nedlands, Western Australia, Australia

Site Status

University Hospital Innsbruck

Innsbruck, , Austria

Site Status

Universitätsklinik für Innere Medizin 3 der PMU

Salzburg, , Austria

Site Status

Medizinische Universitat Wien, Univ. Klinik fur Innere Medizin I Klinische Abteilung fur Onkologie

Vienna, , Austria

Site Status

Klinikum Wels-Grieskirchen

Wels, , Austria

Site Status

GZA Ziekenhuizen - Campus Sint-Augustinus

Antwerp, , Belgium

Site Status

AZ Klina

Brasschaat, , Belgium

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Cliniques Universitaires Saint-Luc

Brussels, , Belgium

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Universitaire Ziekenhuis Leuven

Leuven, , Belgium

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CHU UCL Namur-Site STE. Elisabeth

Namur, , Belgium

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Hospital Haroldo Juaçaba - Instituto do Câncer do Ceará

Fortaleza, , Brazil

Site Status

Hospital Araujo Jorge - Associacao de Combate ao Cancer em Goias

Goiânia, , Brazil

Site Status

Oncosite - Centro de Pesquisa Clinica e Oncologia

Ijuí, , Brazil

Site Status

Catarina Pesquisa Clinica

Itajaí, , Brazil

Site Status

Oncoclinicas do Brasil Servicos Medicos AS

Minas Gerais, , Brazil

Site Status

Liga Norte-Rio-Grandense Contra o Câncer

Natal, , Brazil

Site Status

CIONC-Centro Integrado de Oncologia de Curitiba

Paraana, , Brazil

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Hospital Erasto Gaertner

Paraná, , Brazil

Site Status

IMIP - Instituto de Medicina Integral Professor Fernando Figueira

Pernambuco, , Brazil

Site Status

Irmandade da Santa Casa de Misericórdia de Porto Alegre

Porto Alegre, , Brazil

Site Status

Hospital de Clínicas de Porto Alegre - HCPA

Porto Alegre, , Brazil

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HGB - Hospital Giovanni Battista/Mãe de Deus Center

Porto Alegre, , Brazil

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Hospital São Lucas da PUCRS

Porto Alegre, , Brazil

Site Status

Instituto Americas

Rio de Janeiro, , Brazil

Site Status

Clínica de Oncologia de Porto Alegre Ltda - CLINIONCO

Rio Grande, , Brazil

Site Status

Unidade de PesquisasClinicas em Oncologia - UPCO

Rio Grande, , Brazil

Site Status

Instituto do Câncer - Hospital São Vicente de Paulo

Rio Grande, , Brazil

Site Status

CEPHO - Centro de Estudos e Pesquisas de Hematologia e Oncologia

Santo André, , Brazil

Site Status

Instituto Hemomed Oncologia e Hematologia

São Paulo, , Brazil

Site Status

Clinica de pesquisa e centro de estudos em oncologia ginecológica e mamaria

São Paulo, , Brazil

Site Status

BC Cancer - Kelowna

Kelowna, , Canada

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The Ottawa Hospital Cancer Centre

Ottawa, , Canada

Site Status

CHU de Québec-Université Laval, Hôpital du Saint-Sacrement

Québec, , Canada

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Humber River Hospital

Toronto, , Canada

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BC Cancer-Victoria

Victoria, , Canada

Site Status

Centro de Investigacion Clinica Bradford Hill

Recoleta, , Chile

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Centro del Cancer UC

Region Metropolitana, , Chile

Site Status

Centro de Oncología de Precisión (COP)

Santiago Region, , Chile

Site Status

James Lind Centro de Investigacion del Cancer

Temuco, , Chile

Site Status

Oncocentro APYS

Viña del Mar, , Chile

Site Status

The First Affiliated Hospital of USTC (Anhui Provincial Hospital)

Anhui, , China

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Peking University People's Hospital

Beijing, , China

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The First Hospital of Jilin University

Changchun, , China

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Xiangya Hospital Central South University

Changsha, , China

Site Status

West China Hospital Sichuan University

Chengdu, , China

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Chongqing University Cancer Hospital

Chongqing, , China

Site Status

Fujian Cancer Hospital

Fujian, , China

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Fujian Medical University Union Hospital

Fuzhou, , China

Site Status

Sun Yat-Sen University Cancer Center

Guangdong, , China

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Guangdong Provincial People's Hospital

Guangzhou, , China

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The First Affiliated Hospital of Sun Yat-sen University

Guangzhou, , China

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Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University

Guangzhou, , China

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Sir Run Run Shaw Hospital,Zhejiang University School of Medicine

Hangzhou, , China

Site Status

Zhejiang Cancer Hospital

Hangzhou, , China

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Harbin Medical University Cancer Hospital

Heilongjiang, , China

Site Status

Jiangsu Province Hospital

Jiangsu, , China

Site Status

The First Affiliated Hospital of Soochow University

Jiangsu, , China

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The Nanchang Third Hospital

Jiangxi, , China

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The Second Hospital of Jilin University

Jilin Sheng, , China

Site Status

Affiliated Cancer Hospital of Shandong First Medical University

Jinan, , China

Site Status

The First Affiliated Hospital of Nanchang University

Nanchang, , China

Site Status

General Hospital of Ningxia Medical University

Ningxia Hui, , China

Site Status

The Affiliated Hospital Of Qingdao University

Qingdao, , China

Site Status

Fudan University Shanghai Cancer Center

Shanghai, , China

Site Status

Tianjin Medical University Cancer Institute & Hospital

Tianjin, , China

Site Status

Hubei Cancer Hospital

Wuhan, , China

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The First Affiliated Hospital of Xi'an Jiaotong University

Xi'an, , China

Site Status

The Second Affiliated Hospital of Zhejiang University School of Medicine

Zhejiang, , China

Site Status

Henan Cancer Hospital

Zhengzhou, , China

Site Status

Fakultni Nemocnice Brno

Brno, , Czechia

Site Status

Masaryk Memorial Cancer Institute

Brno, , Czechia

Site Status

University Hospital Olomouc

Olomouc, , Czechia

Site Status

Multiscan s.r.o

Pardubice, , Czechia

Site Status

Charles General University Hospital, Prague

Prague, , Czechia

Site Status

Fakultni nemocnice v Motole

Prague, , Czechia

Site Status

Krajska nemocnice Tomase Bati Zlin

Zlín, , Czechia

Site Status

CHU Jean Minjoz

Besançon, , France

Site Status

Institut Bergonié

Bordeaux, , France

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Centre Georges François Leclerc

Dijon, , France

Site Status

Centre Oscar Lambret

Lille, , France

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Clinique Francois Chenieux

Limoges, , France

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Ico René Gauducheau

Loire Atlantique, , France

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Centre Leon Berard

Lyon, , France

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Institut Paoli Calmettes

Marseille, , France

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Institut Regional du Cancer de Montpellier

Montpellier, , France

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Institut Curie

Paris, , France

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Centre Hospitalier Lyon-Sud

Pierre-Bénite, , France

Site Status

Hopital Privé des Cotes d'Armor

Plérin, , France

Site Status

Centre Jean Bernard Service d'Oncologie Médicale

Rennes, , France

Site Status

Centre Henri Becquerel

Rouen, , France

Site Status

Institut Universitaire du Cancer de Toulouse Oncopole

Toulouse, , France

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Institut Gustave Roussy

Villejuif, , France

Site Status

Universitaetsklinikum Freiburg, Klinik fuer Frauenheilkunde

Baden-Württemberg, , Germany

Site Status

University Hospital rechts der Isar Technical University of Munich

Bayern, , Germany

Site Status

Vivantes Klinikum am Urban

Berlin, , Germany

Site Status

HELIOS Klinikum Berlin-Buch

Berlin, , Germany

Site Status

Marienhospital Bottrop

Bottrop, , Germany

Site Status

Universitätsklinik Erlangen

Erlangen, , Germany

Site Status

SRH Wald-Klinikum Gera GmbH

Gera, , Germany

Site Status

Universitatsklinikum Hamburg-Eppendorf

Hamburg, , Germany

Site Status

Medizinische Hochschule Hannover

Hanover, , Germany

Site Status

Nationales Centrum für Tumorerkrankungen Heidelberg

Heidelberg, , Germany

Site Status

Universitätsklinikum Mannheim

Mannheim, , Germany

Site Status

LMU Klinikum der Universitat München

München, , Germany

Site Status

Universitatsklinikum Munster

Münster, , Germany

Site Status

Universitäts - Frauenklinik

Tübingen, , Germany

Site Status

Alexandra General Hospital

Athens, , Greece

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Attikon Hospital

Athens, , Greece

Site Status

University Hospital of Heraklion

Heraklion, , Greece

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University Hospital of Larissa

Larissa, , Greece

Site Status

University Hospital of Patras

Pátrai, , Greece

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Bioclinic of Thessaloniki

Thessaloniki, , Greece

Site Status

Euromedica General Clinic of Thessaloniki

Thessaloniki, , Greece

Site Status

Hong Kong Integrated Oncology Centre

Hong Kong, , Hong Kong

Site Status

Prince of Wales Hospital

New Territories, , Hong Kong

Site Status

Queen Mary Hospital

Pok Fu Lam, , Hong Kong

Site Status

Semmelweis Egyetem, Belgyogyaszati es Onkologiai Klinika

Budapest, , Hungary

Site Status

Debreceni Egyetem Klinikai Központ

Debrecen, , Hungary

Site Status

Bács-Kiskun Varmegyei Oktatokorhaz, Onkaradiologiai Kozpont

Kecskemét, , Hungary

Site Status

Szabolcs-Szatmar-Bereg Varmegyei Oktatokorhaz, Onkoradiologia

Nyíregyháza, , Hungary

Site Status

Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont

Szeged, , Hungary

Site Status

Oncology Institute Rambam Health Care Campus

Haifa, , Israel

Site Status

Shaare Zedek Medical Center

Jerusalem, , Israel

Site Status

Hadassah Medical Center

Jerusalem, , Israel

Site Status

Rabin Medical Center

Petah Tikva, , Israel

Site Status

Sheba Medical Center

Ramat Gan, , Israel

Site Status

Tel Aviv Sourasky Medical Center

Tel Aviv, , Israel

Site Status

Azienda Ospedaliero Universitaria Ospedali Riuniti di Ancona

Ancona AN, , Italy

Site Status

Centro di Riferimento Oncologico - IRCCS

Aviano, , Italy

Site Status

Humanitas Gavazzeni

Bergamo, , Italy

Site Status

ASST Papa Giovanni XXIII

Bergamo, , Italy

Site Status

IRCCS Azienda Ospedaliero-Universitaria di Bologna Policlinico di Sant'Orsola

Bologna, , Italy

Site Status

Humanitas Istituto Clinico Catanese

Catania, , Italy

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Azienda Ospedaliera Mater Domini

Catanzaro, , Italy

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IRCCS Ospedale Policlinico San Martino

Genova GE, , Italy

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Istituto Europeo di Oncologia

Milan, , Italy

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Fondazione IRCCS San Raffaele del Monte Tabor

Milan, , Italy

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Azienda Ospedaliera San Gerardo

Monza, , Italy

Site Status

Istituto Nazionale Tumori IRCCS Fondazione G. Pascale

Napoli, , Italy

Site Status

Istituto Oncologico Veneto IOV

Padua, , Italy

Site Status

Irccs Crob

Rionero in Vulture, , Italy

Site Status

Azienda Ospedaliero-Universitaria Policlinico Umberto I

Roma, , Italy

Site Status

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Roma, , Italy

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Istituto Clinico Humanitas

Rozzano, , Italy

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Aichi Cancer Center Hospital

Aichi, , Japan

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Tohoku University Hospital

Aoba-ku, , Japan

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Juntendo University Hospital

Bunkyō City, , Japan

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Chiba Cancer Center

Chiba, , Japan

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National Cancer Center Hospital

Chūōku, , Japan

Site Status

Osaka Prefectural Hospital Organization Osaka International Cancer Institute

Chūōku, , Japan

Site Status

National Hospital Organization Shikoku Cancer Center

Ehime, , Japan

Site Status

Fukushima Medical University Hospital

Fukushima, , Japan

Site Status

Social Medical Corporation Hakuaikai Sagara Hospital

Kagoshima, , Japan

Site Status

Tokai University Hospital

Kanagawa, , Japan

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National Cancer Center Hospital East

Kashiwa, , Japan

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Saitama Cancer Center

Kitaadachi-gun, , Japan

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Cancer Institute Hospital of JFCR

Kōtoku, , Japan

Site Status

Kumamoto University Hospital

Kumamoto, , Japan

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Kyoto University Hospital

Kyoto, , Japan

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National Hospital Organization Kyushu Cancer Center

Minamiku, , Japan

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Nagoya University Hospital

Nagoya, , Japan

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Hiroshima City Hiroshima Citizens Hospital

Nakaku, , Japan

Site Status

Hyogo Medical University Hospital

Nishinomiya-shi, , Japan

Site Status

Okayama University Hospital

Okayama, , Japan

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Gunma Prefectural Cancer Center

Ōta-ku, , Japan

Site Status

National Hospital Organization Hokkaido Cancer Center

Sapporo, , Japan

Site Status

Center Hospital of the National Center for Global Health and Medicine

Shinjuku-ku, , Japan

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Showa University Hospital

Tokyo, , Japan

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Kanagawa Cancer Center

Yokohama, , Japan

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Hospital Kuala Lumpur

Kuala Lumpur, , Malaysia

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University Malaya Medical Centre

Kuala Lumpur, , Malaysia

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Sarawak General Hospital

Kuching, , Malaysia

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Institut Kanser Negara

Putrajaya, , Malaysia

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Centro de Investigacion y Avances Medicos Especializados

Cancún, , Mexico

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COI Centro Oncologico Internacional S.A.P.I. de C.V.

Mexico City, , Mexico

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FUCAM

México, , Mexico

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Hospital Universitario Dr. José Eleuterio González

Monterrey, , Mexico

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Clinica Integral Internacional de Oncologia S de RL de CV

Puebla City, , Mexico

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Centro Medico Zambrano Hellion

San Pedro Garza García, , Mexico

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Centro de Atención e Investigación Clínica en Oncología

Yucatán, , Mexico

Site Status

Copemicus Podmiot Leczniczy Wojewodzkie Centrum Okologii w Gdansku

Gdansk, , Poland

Site Status

Szpital Specjalistyczny im. Ludwika Rydygiera w Krakowie Sp. z.o.o

Krakow, , Poland

Site Status

Instytut MSF Sp. z o.o.

Lodz, , Poland

Site Status

Wojewodzki Szpital Specjalistyczny lm. Stefana Kardynala Wyszynsklego SPZOZ w Lublinie

Lublin, , Poland

Site Status

LUX MED Onkologia Sp. Zo.o.

Warsaw, , Poland

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Maria Sklodowska - Curie Institute of Oncology

Warsaw, , Poland

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Centro Clinico Academico - Hospital de Braga

Braga, , Portugal

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Hospital da Senhora da Oliveira Guimaraes

Guimarães, , Portugal

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Centro Hospitalar de Lisboa Central, E.P.E . - Hospital de Santo Antonio dos Capuchos

Lisbon, , Portugal

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Fundacao Champalimaud

Lisbon, , Portugal

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Centro Hospitalar Lisboa Norte, EPE

Lisbon, , Portugal

Site Status

Unidade Local de Saude de Matosinhos EPE - Hospital Pedro Hispano

Matosinhos Municipality, , Portugal

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National University Hospital

Singapore, , Singapore

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National Cancer Centre Singapore

Singapore, , Singapore

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Tan Tock Seng Hospital

Singapore, , Singapore

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Wilgers Oncology Centre

Gauteng, , South Africa

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Wits Clinical Research

Johannesburg, , South Africa

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The Medical Oncology Centre of Rosebank

Johannesburg, , South Africa

Site Status

Cape Town Oncology Trials

Kraaifontein, , South Africa

Site Status

Samsung Medical Center

Gangnam-Gu, , South Korea

Site Status

National Cancer Center

Goyang-si Gyeonggi-do, , South Korea

Site Status

Kyungpook National University Chilgok Hospital

Gyeongsangbuk-do, , South Korea

Site Status

Gachon University Gil Medical Center

Incheon, , South Korea

Site Status

Seoul National University Bundang Hospital

Seongnam, , South Korea

Site Status

Korea University Anam Hospital

Seoul, , South Korea

Site Status

Seoul National University Hospital

Seoul, , South Korea

Site Status

Severance Hospital, Yonsei University Health System

Seoul, , South Korea

Site Status

Asan Medical Center

Seoul, , South Korea

Site Status

Hospital Universitari Dexeus

Barcelona, , Spain

Site Status

Hospital Clinic de Barcelona

Barcelona, , Spain

Site Status

Hospital Universitari Vall D'Hebron

Barcelona, , Spain

Site Status

Hospital de Basurto

Bilbao, , Spain

Site Status

Hospital Universitario Reina Sofia

Córdoba, , Spain

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Hospital General Universitario De Elche

Elche, , Spain

Site Status

Hospital Universitario de Jaen

Jaén, , Spain

Site Status

Hospital Beata María Ana

Madrid, , Spain

Site Status

Hospital General Universitario Gregorio Marañón

Madrid, , Spain

Site Status

MD Anderson Cancer Center

Madrid, , Spain

Site Status

Hospital Universitario Ramón y Cajal

Madrid, , Spain

Site Status

Hospital Clinico San Carlos

Madrid, , Spain

Site Status

Hospital Universitario 12 de Octubre

Madrid, , Spain

Site Status

Hospital Universitario de Salamanca

Salamanca, , Spain

Site Status

Hospital Clínico Universitario de Santiago de Compostela - CHUS

Santiago de Compostela, , Spain

Site Status

Hospital Universitario Virgen del Rocio

Seville, , Spain

Site Status

Hospital Universitario Virgen Macarena

Seville, , Spain

Site Status

Instituto Valenciano De Oncologia (IVO)

Valencia, , Spain

Site Status

Hospital Clínico Universitario de Valencia

Valencia, , Spain

Site Status

Kaohsiung Medical University Chung-Ho Memorial Hospital

Kaohsiung City, , Taiwan

Site Status

Kaohsiung Chang Gung Memorial Hospital

Kaohsiung City, , Taiwan

Site Status

Taipei Medical University - Shuang Ho Hospital, Ministry of Health and Welfare

New Taipei City, , Taiwan

Site Status

National Cheng Kung University Hospital

Tainan City, , Taiwan

Site Status

Chi Mei Hospital, Liouying

Tainan City, , Taiwan

Site Status

National Taiwan University Hospital

Taipei, , Taiwan

Site Status

Taipei Veterans General Hospital

Taipei, , Taiwan

Site Status

Tri-Service General Hospital

Taipei, , Taiwan

Site Status

Koo Foundation Sun Yat-Sen Cancer Center

Taipei, , Taiwan

Site Status

Chang Gung Memorial Hospital, Linkou

Taoyuan, , Taiwan

Site Status

Barts Cancer Institute

London, , United Kingdom

Site Status

University College London Hospitals

London, , United Kingdom

Site Status

The Royal Marsden NHS Foundation Trust

London, , United Kingdom

Site Status

The Christie NHS Foundation Trust

Manchester, , United Kingdom

Site Status

Nottingham University Hospitals NHS Trust

Nottingham, , United Kingdom

Site Status

Countries

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United States Argentina Australia Austria Belgium Brazil Canada Chile China Czechia France Germany Greece Hong Kong Hungary Israel Italy Japan Malaysia Mexico Poland Portugal Singapore South Africa South Korea Spain Taiwan United Kingdom

References

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Tarantino P, Tolaney SM, Curigliano G. Trastuzumab deruxtecan (T-DXd) in HER2-low metastatic breast cancer treatment. Ann Oncol. 2023 Oct;34(10):949-950. doi: 10.1016/j.annonc.2023.07.003. Epub 2023 Jul 26. No abstract available.

Reference Type DERIVED
PMID: 37499870 (View on PubMed)

Related Links

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Other Identifiers

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2022-502593-17-00

Identifier Type: OTHER

Identifier Source: secondary_id

jRCT2061230032

Identifier Type: OTHER

Identifier Source: secondary_id

DOH-27-082023-6901

Identifier Type: OTHER

Identifier Source: secondary_id

MOH_2023-07-17_012821

Identifier Type: OTHER

Identifier Source: secondary_id

CTR20233370

Identifier Type: REGISTRY

Identifier Source: secondary_id

GS-US-598-6168

Identifier Type: -

Identifier Source: org_study_id

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