Evaluation of Carpal Tunnel Syndrome in Pregnancy

NCT ID: NCT05839769

Last Updated: 2023-10-04

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 60 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2023-04-10
• Study Completion Date: 2023-09-10

Brief Summary

Carpal tunnel syndrome (CTS) is a condition that happens when the median nerve in the wrist gets compressed, causing pain, numbness, and tingling in the hand and fingers. It's a common condition that affects between 3% and 6% of people in the general population.

During pregnancy, CTS can be a bigger problem because hormonal changes can cause swelling and put more pressure on the median nerve. Studies show that CTS can affect up to 45% of pregnant women, making it important to identify and manage.

CTS can be diagnosed through a physical exam by a doctor, who will check for symptoms like pain, tingling, or weakness in the hand and fingers. Ultrasound can also be used to diagnose CTS by measuring the size of the median nerve in the wrist. This is a non-invasive imaging technique that is generally considered reliable for diagnosing CTS.

In previous studies, ultrasound has been used to measure the size of the median nerve in pregnant women with carpal tunnel syndrome (CTS). However, a new ratio of median nerve cross-sectional area to flexor carpi radialis cross-sectional area (MN-CSA/FCR-CSA) has not been studied in pregnant women. This ratio may be a more sensitive diagnostic tool for CTS because it is not affected by swelling, which is a common symptom during pregnancy that can affect the size of the median nerve.

Detailed Description

Carpal tunnel syndrome (CTS) is a condition that arises due to the compression of the median nerve in the carpal tunnel of the wrist. The prevalence of CTS in the general population is estimated to be between 3% and 6%, with higher rates in certain occupations or activities that involve repetitive hand movements or vibrations.

During pregnancy, CTS can be particularly important due to hormonal changes that can cause an increase in fluid retention and pressure on the median nerve. The prevalence of CTS during pregnancy varies widely in the literature, with some studies reporting rates as high as 45%.

Ultrasound is a non-invasive imaging technique that can be used to diagnose CTS by measuring the cross-sectional area of the median nerve. While there is some debate regarding the normative values of median nerve cross-sectional area, ultrasound is generally considered a reliable diagnostic tool for CTS.

Previous research has utilized ultrasound to measure the cross-sectional area of the median nerve (MN-CSA) in pregnant women diagnosed with carpal tunnel syndrome (CTS). However, the potential diagnostic value of the MN-CSA/flexor carpi radialis cross-sectional area (FCR-CSA) ratio has not been examined in this population. Given that edema, a common symptom of pregnancy, may affect MN-CSA but not MN-CSA/FCR-CSA ratio, this novel ultrasound parameter may offer superior sensitivity for diagnosing CTS in pregnant women.

Conditions

Carpal Tunnel; Carpal Tunnel Syndrome

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: PROSPECTIVE

Study Groups

carpal tunnel syndrome in third trimester pregnant women

pregnant women who has CTS

Evaluation of median nerve with ultrasound

Intervention Type: DIAGNOSTIC_TEST

ultrasound examination wrist

healthy pregnant women in third trimester

Evaluation of median nerve with ultrasound

Intervention Type: DIAGNOSTIC_TEST

ultrasound examination wrist

Interventions

Evaluation of median nerve with ultrasound

ultrasound examination wrist

Intervention Type: DIAGNOSTIC_TEST

Eligibility Criteria

Inclusion Criteria

• have undergone provocation tests during physical examination that match the median nerve distribution, and are experiencing symptoms of numbness, tingling, weakness and pain in the hands that have persisted for at least one month, and have been diagnosed with carpal tunnel syndrome through electromyography.

Exclusion Criteria

• a history of carpal tunnel surgery
• gestational diabetes mellitus
• eclampsia or preeclampsia
• thyroid disorders
• arthropathies, hand or wrist trauma
• bilateral fractures
• atrial fibrillation
• cervical radiculopathy
• peripheral neuropathy
• thoracic outlet syndrome
• diabetes mellitus
• hypothyroidism
• hyperthyroidism
• rheumatologic disease.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 40 Years
• Eligible Sex: FEMALE
• Accepts Healthy Volunteers: Yes

Sponsors

Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization

OTHER

Sponsor Role: lead

Responsible Party

fatih sahin

MD / Principal Investigator

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Prof. Dr. Cemil Taşcıoğlu City Hospital

Istanbul, , Turkey (Türkiye)

Countries

Turkey (Türkiye)

References

Falsetti P, Conticini E, Baldi C, D'Ignazio E, Al Khayyat SG, Bardelli M, Gentileschi S, D'Alessandro R, D'Alessandro M, Acciai C, Ginanneschi F, Cantarini L, Frediani B. A Novel Ultrasonographic Anthropometric-Independent Measurement of Median Nerve Swelling in Carpal Tunnel Syndrome: The "Nerve/Tendon Ratio" (NTR). Diagnostics (Basel). 2022 Oct 28;12(11):2621. doi: 10.3390/diagnostics12112621.

Reference Type: BACKGROUND

PMID: 36359465 (View on PubMed)

Other Identifiers

88

Identifier Type: -

Identifier Source: org_study_id