The Use of Platelet-rich Plasma in the Treatment of Chronic Anal Fissure
NCT ID: NCT05837403
Last Updated: 2023-05-03
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
PHASE3
460 participants
INTERVENTIONAL
2020-10-01
2022-09-30
Brief Summary
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Detailed Description
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The mixture centrifuged for 3000 round per minute for three minutes. After centrifugation separation of supernatant from the red blood cells, using three way-stopcock connector to collect the supernatant of all syringes into four new syringes that preloaded with 1 microgram of Prostaglandin E1 that diluted in normal saline (0.05 milliliters).
The four syringes centrifuge at 4000 round per minute for 15 minutes. The supernatant discarded using a three way-stopcock connector. The sediment mixed with vortex mixer (Vortex V-1 plus, BIOSAN).
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
TRIPLE
Study Groups
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Nitroglycerin only
application of local Nitroglycerin ointment 2% (Recto-Relief Nitroglycerin Ointment, 30 g) applied twice daily.
Nitroglycerin ointment
application of the ointment twice daily
platelet rich plasma injection
injection of platelet rich plasma under fissure base and edges
Platelet rich plasma injection
venous blood drown from the patient, centrifugation and separation of platelet rich plasma, injection under fissure and edges base.
Nitroglycerin ointment
application of the ointment twice daily
Interventions
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Platelet rich plasma injection
venous blood drown from the patient, centrifugation and separation of platelet rich plasma, injection under fissure and edges base.
Nitroglycerin ointment
application of the ointment twice daily
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* inflammatory bowel disease
* tuberculosis fissure
* HIV infected patients
18 Years
50 Years
ALL
No
Sponsors
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Al-Kindy College of Medicine
OTHER
Responsible Party
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Principal Investigators
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Taghreed Alhaidari, C.A.B.O.G
Role: STUDY_CHAIR
Al-Kindy College of Medicine
Locations
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Al-Kindy Teaching Hospital
Baghdad, , Iraq
Countries
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Other Identifiers
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14 Al-KindyCM
Identifier Type: -
Identifier Source: org_study_id
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