A Study of OMX-0407 in Patients With Previously Treated Solid Tumours That Can't be Removed Surgically

NCT ID: NCT05826600

Last Updated: 2026-01-06

Basic Information

• Recruitment Status: ACTIVE_NOT_RECRUITING
• Clinical Phase: PHASE1/PHASE2
• Total Enrollment: 188 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2023-03-30
• Study Completion Date: 2026-06-30

Brief Summary

The main purpose of the dose escalation phase of the study is to determine the safety of different doses of OMX-0407.

The dose expansion (phase Ib) part of the study will evaluate efficacy, safety and tolerability at a dose determined in the dose escalation,

Conditions

Solid Tumor

Study Design

• Allocation Method: NA
• Intervention Model: SEQUENTIAL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

OMX-0407 - Escalation Phase

A starting daily dose of 20 mg OMX-0407 per participant split into twice daily 10 mg.

Dose escalation will be determined by the safety monitoring committee. Dose for expansion will be determined by the safety monitoring committee.

Group Type: EXPERIMENTAL

OMX-0407

Intervention Type: DRUG

Dose escalation, Dose expansion

OMX-0407 - Expansion Phase (Phase Ib)

A dose of 100 mg OMX-0407 will be orally administered twice daily.

Group Type: EXPERIMENTAL

OMX-0407

Intervention Type: DRUG

Dose escalation, Dose expansion

Interventions

OMX-0407

Dose escalation, Dose expansion

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

1. Age ≥18 years (≥16 years for the AS expansion cohort) and willing to provide informed consent for the study.

2. Cytological or pathological confirmation of advanced cancer.

3. Subjects treated in three subject cohorts onwards will be required to provide either archival tumour material or be willing to undergo a core biopsy to provide tumour material during screening.

4. Subjects should have completed or be unsuitable for licensed therapies for their primary cancer unless such therapies are not available according to local practice - for example not reimbursed or included in treatment guidelines. All subjects must have received at least one previous line of systemic therapy for the tumour type under investigation. Subjects who have declined treatment or according to their treating physician are unsuitable for an existing licensed therapy are eligible for the study.

5. Eastern Cooperative Oncology Group (ECOG) Performance status 0, 1 or 2. Subjects treated in the cohort expansion phase of the study should have an ECOG Performance status of 0 or 1.

6. Able to swallow oral medication with no existing evidence of underlying gastrointestinal malabsorption or abnormal gastrointestinal transit.

7. For female subjects and male partners of childbearing potential, willingness and able to use two forms of highly effective contraception methods (e.g., oral contraceptive and condom, intra-uterine device, and condom) while on study and for 30 days after the last study treatment. For male subjects and female partners of childbearing potential, willingness and able to use two forms of highly effective contraception methods (e.g., oral contraceptive and condom, intra-uterine device, and condom) while on study and for 3 months after the last study treatment. Women who last experienced menses more than one year previously or who have undergone bilateral ovariectomy, hysterectomy or tubal ligation which is documented in their medical notes do not require to use contraception during or after treatment with OMX-0407. Male subjects who have previously undergone vasectomy are not required to use contraception.

8. All toxicity from previous anti-cancer therapy including radiotherapy must have recovered to either Grade I or stable Grade II (CTCAE v5).

9. Subjects should have at least evaluable tumour by Response Evaluation Criteria in Solid Tumours (RECIST) 1.1 criteria. Subjects treated in the Cohort Expansion phases of the study should have measurable disease.

1. Prior histological confirmation of clear cell renal cell carcinoma. In the case of mixed histology in order to be eligible at least 70% of reviewed tumour should be of clear cell histology.

2. Subjects with known renal vascular involvement should be on stable anticoagulation at the start of treatment with OMX-0407. Tumour/skin biopsies should be performed prior to the onset of anticoagulation.

3. Previous treatment must include PD-1 blockade and VEGFR inhibition.

1. Clinical and histopathological confirmation of advanced/metastatic or unresectable visceral AS, cutaneous AS secondary to radiotherapy or other cutaneous AS.

2. Subjects should have progressive disease

3. Subject has received at least one prior line of systemic therapy for metastatic or unresectable disease which must have included a taxane or an anthracycline.

4. Willingness to undergo serial tumour biopsies before and during study treatment.

Patient will still be eligible if the investigator deems the biopsy procedure to be an unacceptable health risk to the patient.

Exclusion Criteria

1. Untreated CNS metastases. Subjects with CNS metastases that have completed treatment at least two weeks previously and have either an unchanging or no neurological deficit whilst not receiving corticosteroid therapy are eligible. Subjects with known CNS metastases must have received CNS directed therapy and not systemic therapy alone to be eligible for the study.

2. Either Aspartate aminotransferase (AST) or Alanine aminotransferase (ALT) > 2.5 upper limit of normal (ULN) unless in the presence of hepatic metastases when AST or ALT as high as 5 ULN is acceptable. Serum bilirubin > 1.5 ULN unless in the presence of hepatic metastases when serum bilirubin as high as 3 x ULN is acceptable. Subjects with isolated increases in alkaline phosphatase (ALK) are eligible for the study.

3. Prothrombin Time or equivalent such as international normalized ratio (INR) or the Quick test > 1.5 ULN.

4. Activated Partial Thromboplastin Time (PTT) > 1.5 ULN.

5. Chronic anticoagulant therapy that cannot be discontinued for tumour biopsy if necessary.

6. Previous biological or unlicensed anticancer therapy within five half-lives or thirty days of treatment - whichever is shortest.

7. Prior cytotoxic chemotherapy in the preceding three weeks.

8. Persistent fever or other signs of uncontrolled infection.

9. Creatinine clearance by Cockcroft-Gault formula or local equivalent < 30 ml/min.

10. Allergy to OMX-0407 or any of its excipients.

11. Personal or family history of long QT syndrome or sudden death.

12. Family or personal history of ventricular arrythmia. Known untreated aberrant preexcitation pathways such as Wolf-Parkinson-White syndrome. Ongoing atrial fibrillation unless the ventricular rate is controlled by medical therapy.

13. Unstable hypertension requiring changes in antihypertensive medication within the preceding three months, Myocardial Infarction or Cerebrovascular accident within the preceding three months. Cardiac failure New York Heart Association (NYHA) Grade III or IV.

14. Abnormal echocardiogram (ECHO) according to investigational site criteria including a normal Ejection Fraction.

15. QTc interval after Fridericia correction of greater than 450 ms (man) or 460 ms (woman) (mean of three readings performed at least five minutes apart).

16. Second degree Atrioventricular block or cardiac pacemaker.

17. Subject must have fully recovered from major surgery such as thoracotomy. Open biopsy or insertion of a venous access device does not constitute major surgery.

18. Known active Hepatitis B (HBV) or C (HCV) including subjects receiving antiviral therapy. Subjects with a history of hepatitis are eligible for the study if they are positive for anti-HBs or do not have detectable HCV mRNA at least six weeks from completing antiviral therapy.

19. Ongoing disabling systemic disease such chronic obstructive pulmonary disease (COPD) or depression or other psychiatric illnesses which may reduce study compliance.

20. Ongoing drug dependence or parenteral substance abuse.

21. Concurrent use of medications at risk of Torsade de pointes under normal clinical usage.

22. Live vaccinations in the preceding four weeks.

23. Subjects who have received treatment for another malignancy in the preceding three years other than squamous cell or basal cell carcinoma of the skin, Carcinoma In Situ of the uterine cervix, Ductal Carcinoma In Situ of the breast, non-muscle invasive carcinoma of the bladder, melanoma in situ or adenocarcinoma of the prostate (Gleason score of five or less).

24. Myelosuppression defined as any of the below:

Haemoglobin <9.5 g/dl White Cell Count <2 x 1000 per μl Neutrophils <1.5 x 1000 per μl Platelets <75 000 per μl Independent of haematopoietic growth factors and transfusion

25. Receipt of any other investigational anticancer agent within 28 days prior to first administration of OMX-0407.

26. Female subjects must not be pregnant or breast feeding.

1. More than 3 previous lines of therapy in an unresectable or metastatic setting.

• Minimum Eligible Age: 16 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

iOmx Therapeutics AG

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

Cliniques Universitaires Saint-Luc

Brussels, , Belgium

Universitair Ziekenhuis Gent

Ghent, , Belgium

CHU de Liège

Liège, , Belgium

ZAS Augustinus Afdeling Oncologische Research

Wilrijk, , Belgium

UNICANCER-Institut Bergonie - Nouvelle-Aquitaine

Bordeaux, , France

Universite de Lyon - Centre Leon-Berard (CLB)

Lyon, , France

Assistance Publique Hopitaux de Marseille- Hopital de La Timone

Marseille, , France

Institut du Cancer Montpellier (ICM)

Montpellier, , France

Institut de Cancerologie de Ouest (ICO) - Saint-Herblain

Nantes, , France

UNICANCER - Centre Oscar Lambret

Nantes, , France

Gustave Roussy - Institut Gustave Roussy

Paris, , France

CHU de Toulouse

Toulouse, , France

ICO Hospitalet

L'Hospitalet de Llobregat, Barcelona, Spain

Hospital del Mar

Barcelona, , Spain

Hospital Universitario Vall d'Hebrón

Barcelona, , Spain

NEXT Oncology - Hospital Quironsalud Barcelona

Barcelona, , Spain

Hospital Universitario Gregorio Marañon

Madrid, , Spain

Clínica Universidad de Navarra

Madrid, , Spain

MD Anderson Cancer Center

Madrid, , Spain

START Madrid - Hospital Fundacion Jimenez Diaz

Madrid, , Spain

Centro Integral Oncológico Clara Campal

Madrid, , Spain

NEXT Oncology - Hospital Universitario Quironsalud

Madrid, , Spain

Clínica Universidad de Navarra

Pamplona, , Spain

Hospital La Fe de Valencia

Valencia, , Spain

Countries

Belgium; France; Spain

Other Identifiers

OMX-0407-101

Identifier Type: -

Identifier Source: org_study_id