Personalizing Treatment Delivery

NCT ID: NCT05821634

Last Updated: 2025-05-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

81 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-10-21

Study Completion Date

2027-04-01

Brief Summary

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Anxiety and anxiety-related disorders frequently co-occur with alcohol use problems resulting in an enormous humanitarian and economic cost to society. The proposed research will use digital technology to examine person-specific risk factors predicting problematic alcohol use in individuals vulnerable to anxiety and anxiety-related disorders and will use this information to design a personalized intervention for individuals seeking psychological treatment. Results from this research will integrate output from novel and innovative digital technology methods into psychotherapy, advancing research on personalized treatment and prevention efforts.

Detailed Description

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Conditions

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Anxiety Disorders and Symptoms PTSD and Trauma-related Symptoms Alcohol; Use, Problem; Alcohol Use Disorder

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Outcome Assessors

Study Groups

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Personalized intervention condition

This experimental condition will test a data-driven, person-specific intervention using CBT skills.

Group Type EXPERIMENTAL

Personalized intervention condition: Cognitive behavioral therapy skills

Intervention Type BEHAVIORAL

An 11-session cognitive behavioral therapy (CBT) skills based intervention will be delivered to participants randomized to the personalized intervention. Influential constructs will be identified using the person specific digital phenotyping model, targeted using CBT skills, and tracked across sessions.

Therapeutic control condition

This control condition will provide an experimental comparison to test the process of personalization.

Group Type ACTIVE_COMPARATOR

Therapeutic control condition: Cognitive behavioral therapy skills

Intervention Type BEHAVIORAL

Participants randomized to this condition will receive an 11-session CBT skills based treatment targeting a non-personalized construct selected from the person-specific digital phenotyping model.

Tracking control condition

This second control condition will provide an experimental comparison to test the effects of health-related tracking and therapeutic contact.

Group Type ACTIVE_COMPARATOR

Tracking control condition: Supportive counseling

Intervention Type BEHAVIORAL

Participants randomized to this condition will receive 11 supportive counseling sessions that are non-directive in nature (providing support and validation for non-acute weekly stressors). Participants will continue digital phenotyping, controlling for the effect of counseling and digital phenotyping.

Interventions

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Personalized intervention condition: Cognitive behavioral therapy skills

An 11-session cognitive behavioral therapy (CBT) skills based intervention will be delivered to participants randomized to the personalized intervention. Influential constructs will be identified using the person specific digital phenotyping model, targeted using CBT skills, and tracked across sessions.

Intervention Type BEHAVIORAL

Therapeutic control condition: Cognitive behavioral therapy skills

Participants randomized to this condition will receive an 11-session CBT skills based treatment targeting a non-personalized construct selected from the person-specific digital phenotyping model.

Intervention Type BEHAVIORAL

Tracking control condition: Supportive counseling

Participants randomized to this condition will receive 11 supportive counseling sessions that are non-directive in nature (providing support and validation for non-acute weekly stressors). Participants will continue digital phenotyping, controlling for the effect of counseling and digital phenotyping.

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Access to a smart phone
* Between 18 and 65 years
* Clinically significant anxiety or trauma-related symptoms
* Alcohol use problems
* Interest in telehealth counseling
* Anticipated New Jersey or New York residence for the duration of the study

Exclusion Criteria

* Currently receiving counseling
* Psychiatric medication that is not currently at a stable dose (or is not anticipated to remain at a stable dose for the duration of the study)
* Demonstrated indicators of more intensive or acute care
* Temporary residence within the state of New Jersey or New York or out-of-state residence from the state of New Jersey or New York
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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National Institute on Alcohol Abuse and Alcoholism (NIAAA)

NIH

Sponsor Role collaborator

Rutgers, The State University of New Jersey

OTHER

Sponsor Role lead

Responsible Party

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Marilyn L. Piccirillo, Ph.D.

Assistant Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Marilyn Piccirillo, PhD

Role: PRINCIPAL_INVESTIGATOR

Rutgers Robert Wood Johnson Medical School

Locations

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Rutgers Robert Wood Johnson Medical School

Piscataway, New Jersey, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Marilyn Piccirillo, PhD

Role: CONTACT

732-235-4341

Facility Contacts

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Marilyn Piccirillo, PhD

Role: primary

Other Identifiers

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4R00AA029459-03

Identifier Type: NIH

Identifier Source: secondary_id

View Link

STUDY00013899

Identifier Type: -

Identifier Source: org_study_id

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