Comparison of Clinical Efficacy Between Letrozole + Ribociclib and Fulvestrant + Letrozole + Ribociclib in Hormone Receptor Positive, HER2 Negative Metastatic Breast Cancer

NCT ID: NCT05816655

Last Updated: 2025-03-18

Basic Information

• Recruitment Status: RECRUITING
• Clinical Phase: PHASE2
• Total Enrollment: 202 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2023-05-31
• Study Completion Date: 2029-06-30

Brief Summary

Aromatase inhibitor (AI) + CDK4/6 inhibitor is settled down as the standard first line therapy for HR+/HER2- metastatic breast cancer and all three CDk4/6 inhibitors, palbociclib, ribociclib, and abemaciclib are currently available for same indications. However, there is no effective treatment strategy for patients who have progressed on AI+CDK4/6 inhibitor. In particular, the clinical efficacies of subsequent hormone therapy are lowered when ESR1 mutations, one of mechanisms of AI resistance occur. In the PADA-1 trial, when ESR1 mutations in ctDNA were detected in patients treated with AI+CDK4/6 inhibitor, AI was switched to fulvestrant even if disease progression was not confirmed clinically. As a result, the median PFS was prolonged by about 8 months in this switching group compared to the group in which AI was continued. The results of this study suggested that delaying the occurrence of ESR1 mutations and early response to them are necessary to increase the effectiveness of hormone therapy.

In SWOG S0226 study, fulvestrant + AI combination showed significant benefits in PFS and OS compared to AI monotherapy as the first line therapy. Based on these results, the NCCN guideline suggests fulvestrant + AI combination as one of the first line hormone therapy options. However, the clinical effect of AI + fulvestrant + CDK4/6 inhibitor has not been investigated yet. Therefore, the investigators are planning to compare the clinical efficacy of AI+ fulvestrant + CDK4/6 inhibitor and AI+CDK4/6 inhibitor, and to investigate if a triple combination regimen can delay the emergence of ESR1 mutations and modulate occurred ESR1 mutations.

Conditions

Metastatic Breast Cancer

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Fulvestrant arm

fulvestrant + AI + ribociclib

Group Type: EXPERIMENTAL

Fulvestrant plus AI plus ribociclib

Intervention Type: DRUG

Fulvestrant + AI + ribociclib +/- GnRH agonist

Control arm

AI + ribociclib

Group Type: ACTIVE_COMPARATOR

AI plus ribociclib

Intervention Type: DRUG

AI + ribociclib +/- GnRH agonist

Interventions

Fulvestrant plus AI plus ribociclib

Fulvestrant + AI + ribociclib +/- GnRH agonist

Intervention Type: DRUG

AI plus ribociclib

AI + ribociclib +/- GnRH agonist

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

• Female ≥ 19 years of age
• Histologically confirmed unresectable, locally advanced or metastatic invasive breast cancer with hormone receptor positive/HER2 negative
• No previous history of systemic endocrine or chemotherapy for metastatic, advanced breast cancer.
• If the patient has received AI as adjuvant endocrine therapy, the treatment free interval (TFI) should be more than 12 months after the end of adjuvant endocrine therapy. If the patient has received tamoxifen for adjuvant endocrine therapy, TFI less than 12 months will be allowed.
• ECOG PS 0-2
• Patients should have measurable or evaluable lesion based on RECIST version 1.1
• Patients should have adequate organ function:

• ANC (absolute neutrophil count) ≥ 1.5 × 109/L
• Platelet ≥ 100 × 109/L
• Serum Hb ≥ 9.0 g/dL
• INR ≤1.5
• Serum creatinine ≤ 1.5 X ULN
• ALT & ALT <2.5 X ULN, if patients have hepatic metastasis, ALT & ALT <5.0 X ULN is allowed
• Total serum bilirubin <1.5 X ULN, if patients have hepatic metastasis, Total serum bilirubin <3.0 X ULN is allowed.
• In the case of childbearing potential, patients who can adhere to appropriate contraception during the study period and for at least 6 months after the end of study treatment.
• Patients who understand the contents of the clinical trial and are cooperative with the process of the clinical trial.

Exclusion Criteria

• Patients with a history of previous treatment with a CDK4/6 inhibitor or other systemic treatment for advanced/metastatic breast cancer
• Patients who have received prior treatment with fulvestrant and any investigational ER-directed therapy including SERDs (selective estrogen receptor degrader)
• Patients who have disease recurrence on aromatase inhibitor treatment as adjuvant endocrine therapy
• Patients who have symptomatic or untreated central nervous system metastasis
• Patients who have a history of cardiovascular disease or heart failure as following conditions; within at least 6 months of myocardial infarction, unstable angina, or uncontrolled arrhythmia.
• Patients having visceral crisis which needs rapid tumor reduction
• Patients who have a history of any other cancer (except nonmelanoma skin cancer, carcinoma in-situ of the cervix, well-differentiated thyroid cancer)
• Patients unable to cooperate with periodic blood samples collection
• Patients who have active HBV, HCV infection, immune-suppressive disease, or HIV infection. In case of chronic HBV infection, HBV DNA should be negative. Patients with complete remission of HCV infection are allowed.
• Pregnant or breast-feeding women
• Patients who are considered to be unsuitable for this trial by investigators.

• Minimum Eligible Age: 19 Years
• Maximum Eligible Age: 80 Years
• Eligible Sex: FEMALE
• Accepts Healthy Volunteers: No

Sponsors

Korea University Guro Hospital

OTHER

Sponsor Role: lead

Responsible Party

Park, In Hae

Principal investigator, Clinical professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Korea university Guro hospital

Seoul, , South Korea

Site Status: RECRUITING

St Mary Hospital

Seoul, , South Korea

Site Status: RECRUITING

Countries

South Korea

Facility Contacts

In Hae Park, MD

Role: primary

parkih@korea.ac.kr

+82-2-2626-3172

Jieun Lee, prof

Role: primary

befamiliar@catholic.ac.kr

+82-2-

Other Identifiers

KCSG BR22-20

Identifier Type: -

Identifier Source: org_study_id