Evaluate the Safety and Efficacy of HG102 as Compared to Botox® in Subject With Moderate to Severe Glabellar Lines

NCT ID: NCT05801146

Last Updated: 2024-01-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

PHASE3

Total Enrollment

272 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-01-04

Study Completion Date

2025-10-31

Brief Summary

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To evaluate the efficacy and safety of HG102 for moderate to severe Glabellar Lines, non-inferiority compared to Botox® was confirmed and safety was evaluated.

Detailed Description

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Conditions

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Glabellar Lines

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Botulinum toxin type A(HG102)

Group Type EXPERIMENTAL

Botulinum Toxin Type A Injection [HG102]

Intervention Type DRUG

Single administration, Day 0, 20 units

Botulinum toxin type A(Botox®)

Group Type ACTIVE_COMPARATOR

Botulinum Toxin Type A Injection [Botox]

Intervention Type DRUG

Single administration, Day 0, 20 units

Interventions

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Botulinum Toxin Type A Injection [HG102]

Single administration, Day 0, 20 units

Intervention Type DRUG

Botulinum Toxin Type A Injection [Botox]

Single administration, Day 0, 20 units

Intervention Type DRUG

Other Intervention Names

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HG102 Botox®

Eligibility Criteria

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Inclusion Criteria

* Subjects that fit all of the criteria below were selected for this clinical trial.

1. Male and female adults from 19 to 65 years old at the time of screening
2. Person with moderate or severe glabellar lines and have received Grade 2-3 according to Physician's Rating Line Severity at maximum frown
3. Person who understands and can comply to the process and visiting schedule of this clinical study
4. Person who gave spontaneous written consent to participate in this clinical study

Exclusion Criteria

* Subjects that fit any of the criteria below were excluded from this clinical trial.

1. Person with infection, skin disease, or scar on forehead
2. Person with symptoms of facial palsy or blepharoptosis
3. Person with allergies or hypersensitive reaction history to the ingredients in the investigational product (botulinum toxin formula, serum albumin, etc.)
4. Person who were administered with similar medication within 12 weeks (botulinum toxin type A medication) or 16 weeks (botulinum toxin type B medication)
5. Pregnant and breast-feeding women, men and women in the childbearing age who are planning to get pregnant during the clinical study period, or do not agree to the suitable contraceptive methods
6. Person who participated in another clinical trial, or were given medication for other clinical trials within 4 weeks from screening of 5 times the half-life, which period may be longer
7. Other person who the investigator judges as inappropriate for the clinical trial
Minimum Eligible Age

19 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Hugel

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Hugel

Seoul, , South Korea

Site Status RECRUITING

Countries

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South Korea

Central Contacts

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Cho Long Park

Role: CONTACT

+82-2-6966-1654

Facility Contacts

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ChoLong Park

Role: primary

Other Identifiers

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HG-102GL-PIII-01

Identifier Type: -

Identifier Source: org_study_id

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