Effects of Aerobic Exercise on Skeletal Muscle Remodeling in Colorectal Cancer
NCT ID: NCT05789433
Last Updated: 2025-07-03
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
70 participants
INTERVENTIONAL
2023-05-01
2027-03-01
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
SUPPORTIVE_CARE
DOUBLE
Study Groups
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Attention control
Static stretching
Progressive stretching
Statistic stretching of eight major muscle groups
Aerobic exercise
Aerobic exercise at a dose of 225 minutes per week
Aerobic exercise
Moderate- to vigorous-intensity aerobic exercise
Interventions
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Aerobic exercise
Moderate- to vigorous-intensity aerobic exercise
Progressive stretching
Statistic stretching of eight major muscle groups
Eligibility Criteria
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Inclusion Criteria
* Histologically confirmed stage I, II, or III colon or rectal cancer
* Completed surgical resection with curative intent
* Completed other cancer-directed treatments
* Engage in \<150 minutes per week of moderate- to vigorous-intensity structured endurance exercise
* No planned major surgery during the study period
* Readiness to exercise, as determined by a modified version of the Physical Activity Readiness Questionnaire
* Ability to provide written informed consent
* Provide written approval by a qualified healthcare professional
* Willing to be randomized
Exclusion Criteria
* Concurrently actively treated other (non-colorectal) cancer
* Scheduled to receive other postoperative cancer-directed treatment(s)
* Currently pregnant, breastfeeding, or planning to become pregnant within the next 24 weeks
* Currently participating in another study with competing outcomes
* Contraindications to magnetic resonance imaging
* Any dietary condition or restriction that would limit tolerance of a mixed meal challenge
* Any other cardiovascular, pulmonary, orthopedic, neurologic, psychiatric, or other condition that, in the investigator's opinion, would preclude participation or successful compliance with the protocol
* Any other situation that, in the opinion of the investigator, would negatively impact subject safety or successful compliance with the protocol
18 Years
ALL
No
Sponsors
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National Cancer Institute (NCI)
NIH
AdventHealth Translational Research Institute
OTHER
Responsible Party
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Justin Brown
Director, Exercise & Cancer Biology Research Program
Principal Investigators
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Justin C. Brown, Ph.D.
Role: PRINCIPAL_INVESTIGATOR
AdventHealth
Locations
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AdventHealth
Orlando, Florida, United States
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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PBRC 2022-014
Identifier Type: -
Identifier Source: org_study_id
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