Therapeutic Effect of Green Seaweed Against Metabloc Syndrome

NCT ID: NCT05786534

Last Updated: 2023-09-29

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: NA
• Total Enrollment: 40 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2022-12-09
• Study Completion Date: 2023-11-10

Brief Summary

Metabolic syndrome is a major concern worldwide and in Pakistan as well. Metabolic syndrome is a pathologic condition which includes abdominal obesity, insulin resistance, hypertension and hyperlipidemia. Seafood consumption has been linked to reduced risk of many health conditions including altered blood profile. Green seaweed is known to have a potential in optimizing the blood profile and so, it is helpful in reducing the risk of metabolic syndrome by playing a role in preventing obesity, hyperglycemia, high blood pressure and altered lipid profile. Green seaweed (Ulva Lactuca) powder will prove to have therapeutic potential against obesity, hypertension, glucose intolerance and dyslipidemia.

Detailed Description

Metabolic syndrome is a major concern worldwide and in Pakistan as well. Metabolic syndrome is a pathologic condition which includes abdominal obesity, insulin resistance, hypertension and hyperlipidemia. Seafood consumption has been linked to reduced risk of many health conditions including altered blood profile. Green seaweed is known to have a potential in optimizing the blood profile and so, it is helpful in reducing the risk of metabolic syndrome by playing a role in preventing obesity, hyperglycemia, high blood pressure and altered lipid profile.

Statement of problem: The number of people with high LDL-cholesterol, body mass index and fasting plasma glucose levels has been increasing. These factors are promoting the risk of metabolic syndrome in Pakistan. 26-38% people in Pakistan are reported to be a patient of metabolic syndrome. Seaweed has shown to be protective against the syndrome in previous studies. The goal of this study is to check the role of green seaweed against metabolic syndrome.

Hypothesis: Green seaweed (Ulva Lactuca) has a potential to manage metabolic syndrome.

Objective: To assess the therapeutic effect of green seaweed (Ulva Lactuca) against metabolic syndrome.

Methodology: Green seaweed powder will be procured from Taokaenoi Food and Marketing Public Co., Ltd. (Thailand). The proximate analysis of the product will be performed and then capsules of powder will be prepared to be consumed by the participants. Total 40 subjects (20 in treatment group and 20 in control group) will be selected and green seaweed powder will be added in their diets (200mg twice a day). After a trial of 40 days, the patients will be assessed. Assessment will include anthropometric measurements, blood pressure, lipid profile analysis and total antioxidant capacity (TAC) which will be monitored before and after the trial and final,ly, the data collected will be analyzed by using SPSS 25 by paired sample t test. P value ≤ 0.05 will be considered significant.

Expected outcomes: Green seaweed (Ulva Lactuca) powder will prove to have therapeutic potential against obesity, hypertension, glucose intolerance and dyslipidemia.

Conditions

Metabolic Syndrome

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: SUPPORTIVE_CARE
• Blinding Strategy: NONE

Study Groups

Metabolic Syndrome patients

Green seaweed Ulva Lactuca is used for preventing symptoms in Metabolic Syndrome patients

Group Type: EXPERIMENTAL

Green Seaweed

Intervention Type: DIETARY_SUPPLEMENT

400 mg per day

Interventions

Green Seaweed

400 mg per day

Intervention Type: DIETARY_SUPPLEMENT

Other Intervention Names

Ulva Lactuca

Eligibility Criteria

Inclusion Criteria

• BMI > 25kg/m2
• Dyslipidemia
• Altered blood glucose level
• Age 30-55 ( male and female)

Exclusion Criteria

• Thyroid disorder
• Liver disease
• Kidney disorder
• Cancer etc

• Minimum Eligible Age: 35 Years
• Maximum Eligible Age: 55 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

University of Veterinary and Animal Sciences, Lahore - Pakistan

OTHER

Sponsor Role: lead

Responsible Party

Asif Ali

Researcher

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Ashraf Hospital

Chak One Hundred Seventy-five Nine Left, Punjab Province, Pakistan

Countries

Pakistan

References

Cardoso SM, Pereira OR, Seca AM, Pinto DC, Silva AM. Seaweeds as Preventive Agents for Cardiovascular Diseases: From Nutrients to Functional Foods. Mar Drugs. 2015 Nov 12;13(11):6838-65. doi: 10.3390/md13116838.

Reference Type: RESULT

PMID: 26569268 (View on PubMed)

Related Links

https://pubmed.ncbi.nlm.nih.gov/26569268/

Seaweeds as Preventive Agents for Cardiovascular Diseases

Other Identifiers

Green Seaweed

Identifier Type: -

Identifier Source: org_study_id