Development of Rational Ways of Medical and Non-medical Treatment Methods for Metabolic Syndrome
NCT ID: NCT02503865
Last Updated: 2015-11-30
Study Results
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View full resultsBasic Information
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COMPLETED
PHASE1/PHASE2
351 participants
INTERVENTIONAL
2003-01-31
2014-12-31
Brief Summary
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Detailed Description
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Participants and methods: This clinical study included 351 adults (184 female) in the Scientific research institute of cardiology and internal diseases (Almaty, the Republic of Kazakhstan). Statistical analysis was performed using Microsoft Excel-2008 in updating Lapach, Chubenko et al (2000) and SPSS for Windows v.17.0.
Conditions
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Keywords
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
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Conventional Patient group
Xenical, Pionorm, Diroton, Diltiazem, Atorvastatin
Xenical, Pionorm, Diroton, Diltiazem, Atorvastatin
Xenical (Orlistat) - 120 mg/day in integration of Pionorm (Pioglitazone hydrochlorid) - 30 mg/day, Diroton (Lizinopril) - 20 mg/day, Diltiazem - 90 mg/day, Atorvastatin (Liprimar) - 40 mg/day
"Analimentary detoxication" Weight loss
Vegetables and salt diet
"Analimentary detoxication"
Vegetable and salt diet
Healthy people
64 healthy people
No interventions assigned to this group
Interventions
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Xenical, Pionorm, Diroton, Diltiazem, Atorvastatin
Xenical (Orlistat) - 120 mg/day in integration of Pionorm (Pioglitazone hydrochlorid) - 30 mg/day, Diroton (Lizinopril) - 20 mg/day, Diltiazem - 90 mg/day, Atorvastatin (Liprimar) - 40 mg/day
"Analimentary detoxication"
Vegetable and salt diet
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* age\> 25 years
* skinfold thickness \> 0,7 cm BP\> 130/85 mm Hg or a patient on antihypertensive medications fasting blood glucose \> 6.1 mmole/L, or 2-hour postprandial glucose level \> 11.1 mmole/L / or a patient with type 2 diabetes blood cholesterol \> 5.6 mmole/L possibility of treatment \> 6 months follow-up \> 1 year
Exclusion Criteria
* patients with severe concomitant diseases of the kidneys and (or) of the liver
* early post-operative condition
* mental illness
* pregnancy
* persons who are in prison
* persons who are in military Armed Forces
25 Years
74 Years
ALL
Yes
Sponsors
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Institute Of Cardiology & Internal Diseases, Kazakhstan
OTHER_GOV
Nazarbayev University
OTHER
Responsible Party
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Kuat Oshakbayev
Primary investigator
Principal Investigators
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Tabynbayev Nariman, Professor
Role: STUDY_DIRECTOR
Nazarbayev University
Locations
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Republican Scientific Center for Emergency Medicine
Astana, Astana, Kazakhstan
Countries
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References
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Penn L, White M, Lindstrom J, den Boer AT, Blaak E, Eriksson JG, Feskens E, Ilanne-Parikka P, Keinanen-Kiukaanniemi SM, Walker M, Mathers JC, Uusitupa M, Tuomilehto J. Importance of weight loss maintenance and risk prediction in the prevention of type 2 diabetes: analysis of European Diabetes Prevention Study RCT. PLoS One. 2013;8(2):e57143. doi: 10.1371/journal.pone.0057143. Epub 2013 Feb 25.
Berk KA, Buijks H, Ozcan B, Van't Spijker A, Busschbach JJ, Sijbrands EJ. The Prevention Of WEight Regain in diabetes type 2 (POWER) study: the effectiveness of adding a combined psychological intervention to a very low calorie diet, design and pilot data of a randomized controlled trial. BMC Public Health. 2012 Nov 23;12:1026. doi: 10.1186/1471-2458-12-1026.
Browning JD, Baxter J, Satapati S, Burgess SC. The effect of short-term fasting on liver and skeletal muscle lipid, glucose, and energy metabolism in healthy women and men. J Lipid Res. 2012 Mar;53(3):577-586. doi: 10.1194/jlr.P020867. Epub 2011 Dec 3.
Oshakbayev K, Dukenbayeva B, Togizbayeva G, Durmanova A, Gazaliyeva M, Sabir A, Issa A, Idrisov A. Weight loss technology for people with treated type 2 diabetes: a randomized controlled trial. Nutr Metab (Lond). 2017 Jan 31;14:11. doi: 10.1186/s12986-017-0163-9. eCollection 2017.
Other Identifiers
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0103RK00112
Identifier Type: -
Identifier Source: org_study_id