Cumulative Live Birth After Double Stimulation Protocol Versus Antagonist Protocol for Poor Ovarian Responders
NCT ID: NCT05765968
Last Updated: 2023-03-14
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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NOT_YET_RECRUITING
NA
1198 participants
INTERVENTIONAL
2023-03-14
2026-04-01
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
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Double Stimulation Protocol
Double stimulations were performed during the follicular and luteal phases in the same cycle by rFSH\&hmg.
Double Stimulation Protocol
cummulative live birth outcome after two cycles of in virto fertilization using double stimulation protocol, which refers to two cycles of ovarian stimulation in both follicular phase and luteal phase within the same menstrual cycle
Antagonist Stimulation Protocol
The classical antagonist protocol were performed by rFSH,hmg and antagonist.
Antagonist Stimulation Protocol
cummulative live birth outcome within no more than two cycles of in virto fertilization using classical antagonist protocol
Interventions
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Double Stimulation Protocol
cummulative live birth outcome after two cycles of in virto fertilization using double stimulation protocol, which refers to two cycles of ovarian stimulation in both follicular phase and luteal phase within the same menstrual cycle
Antagonist Stimulation Protocol
cummulative live birth outcome within no more than two cycles of in virto fertilization using classical antagonist protocol
Eligibility Criteria
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Inclusion Criteria
2. Women aged ≥20 years old
3. Women who are undergoing their first or second ART cycles
4. Women who are undergoing IVF,ICSI or PGT-A cycles
5. Women with the number of oocyte retrieval ≤9 after their first ovarian stimulation cycle since radomization, and the number of follicle measuring 8mm or larger ≥3
Exclusion Criteria
2. Women diagnosed with uterine abnormalities including uterine malformations, adenomyosis, submucosal fibroids, uterine adhesions or endometrial polyps
3. Women with untreated hydrosalpinx that is visible under pelvic ultrasound
4. Women with chromosomal abnormalities, or women who are undergoning PGT-SR or PGT-M cycles
5. Women with a history of canceled FET cycle(s) due to a thin endometrium (\<7mm)
6. Man with operation to get sperm
20 Years
FEMALE
Yes
Sponsors
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Hunan Provincial Maternal and Child Health Care Hospital
OTHER
Jinghua Hospital of Shenyang
UNKNOWN
Xinjiang Jiayin Hospital
UNKNOWN
The Affiliated Hospital of Inner Mongolia Medical University
OTHER
Guangdong Second Provincial General Hospital
OTHER
The Affiliated Hospital of Qingdao University
OTHER
Wuhan Tongji Reproductive Medicine Hospital
UNKNOWN
Reproductive & Genetic Hospital of CITIC-Xiangya
OTHER
Shandong University
OTHER
Responsible Party
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Chen Zi-Jiang
Academician
Locations
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Shandong University
Jinan, Shandong, China
Countries
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Other Identifiers
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DouAnt
Identifier Type: -
Identifier Source: org_study_id
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