A Multidimensional Study on Articulation Deficits in Parkinsons Disease

NCT ID: NCT05754086

Last Updated: 2024-08-27

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 40 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2021-09-09
• Study Completion Date: 2023-07-31

Brief Summary

Articulatory deficits are present in most speakers with dysarthria, which negatively impacts their speech intelligibility, yet little is known about the relationship between articulatory movement and speech intelligibility. This study will examine the relationship between articulation measures, both acoustic and kinematic, and their relationship to perceptual measures (i.e., speech intelligibility and articulation ratings) in 30 individuals with dysarthria secondary to Parkinson's disease and 30 neurologically healthy adults of the same age. The findings will have implications for behavioral management.

Detailed Description

Dysarthria is a motor speech disorder that affects individuals with various etiologies. Parkinson's disease (PD) alone affects nearly one million individuals in the U.S., with dysarthria developing in approximately 90% of these individuals within the first two years of onset. The dysarthria associated with PD is characterized by reduced movement, which has been supported by findings of reduced lip, tongue, and jaw movement in speakers with PD. However, it remains unclear if hypokinetic dysarthria causes a global reduction across all articulators, or if specific articulators are disproportionally affected by the disease. Further, it is not fully understood what factors contribute to speech intelligibility. Specifically, little is known about the articulatory-kinematic correlates of speech intelligibility. This missing link is vital to understand, as articulation deficits are a universal characteristic of dysarthria, regardless of etiology. The proposed study provides a linked investigation of kinematic, acoustic, and perceptual characteristics in speakers with PD and neurologically healthy speakers.

This research aims to (1) examine the perceptual, acoustic, and articulator-specific movement deficits in speakers with PD and (2) understand the relationship between articulatory movement and measures of speech perception. Specific Aim 1 will examine the group differences between speakers with PD and neurologically healthy speakers using perceptual, acoustic, and articulator-specific kinematic measures. The investigators hypothesize the perceptual, acoustic, and tongue-related kinematic measures will differentiate individuals with PD from neurologically healthy speakers. Specific Aim 2 will model speech intelligibility (Specific Aim 2a) and ratings of articulatory precision (Specific Aim 2b) using selected acoustic and kinematic measurements. The investigators hypothesize that the acoustic measures will be stronger predictors of speech intelligibility than the kinematic measures, as they are both derived from the speech signal. Further, the investigators hypothesize the selected kinematic measures may demonstrate a stronger relationship to articulation ratings than speech intelligibility. This study is a requisite step toward our long-term goal of advancing dysarthria management strategies. The primary outcome will be explanatory models that identify acoustic and articulatory correlates of speech intelligibility and articulatory precision. This study has important implications for developing articulator-specific dysarthria management strategies to supplement universal dysarthria management strategies.

Conditions

Parkinson Disease; Dysarthria, Hypokinetic

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: CROSS_SECTIONAL

Study Groups

Parkinsons (PD) Group

This cohort includes individuals who have been diagnosed with Parkinson's disease.

Clear Speech

Intervention Type: BEHAVIORAL

This behavioral modification asks participants to speak more clearly, as if they were "speaking to someone with a hearing loss".

Less Clear Speech

Intervention Type: BEHAVIORAL

This behavioral modification asks participants to speak less clearly, as if they were "in a room with many people and they were mumbling something to the person next to them that they didn't want other people in the room to hear."

Neurotypical (NT) Group

This group consists of age-matched control participants. They are neurologically healthy and do not have any neurological diagnoses.

Clear Speech

Intervention Type: BEHAVIORAL

This behavioral modification asks participants to speak more clearly, as if they were "speaking to someone with a hearing loss".

Less Clear Speech

Intervention Type: BEHAVIORAL

This behavioral modification asks participants to speak less clearly, as if they were "in a room with many people and they were mumbling something to the person next to them that they didn't want other people in the room to hear."

Interventions

Clear Speech

This behavioral modification asks participants to speak more clearly, as if they were "speaking to someone with a hearing loss".

Intervention Type: BEHAVIORAL

Less Clear Speech

This behavioral modification asks participants to speak less clearly, as if they were "in a room with many people and they were mumbling something to the person next to them that they didn't want other people in the room to hear."

Intervention Type: BEHAVIORAL

Eligibility Criteria

Inclusion Criteria

• neurological diagnosis of PD (for the PD group only)
• diagnosis of dysarthria (for the PD group only)
• native English speaker
• no evidence of cognitive impairment, as indicated by a score above 26 on the Montreal Cognitive Assessment
• able to read a paragraph in 19-point font

Exclusion Criteria

• Not within the age limits

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 85 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

National Institute on Deafness and Other Communication Disorders (NIDCD)

NIH

Sponsor Role: collaborator

Florida State University

OTHER

Sponsor Role: lead

Responsible Party

Yunjung Kim

Principal Investigator

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Yunjung Kim, Ph.D.

Role: STUDY_CHAIR

Florida State University

Locations

Florida State University

Tallahassee, Florida, United States

Countries

United States

Provided Documents

Document Type: Informed Consent Form

View Document

Other Identifiers

F31DC020121

Identifier Type: NIH

Identifier Source: secondary_id

View Link

STUDY00002525

Identifier Type: -

Identifier Source: org_study_id