CKD-702 Plus Irinotecan in Gastric Cancer

NCT ID: NCT05750290

Last Updated: 2023-03-01

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

PHASE2

Total Enrollment

40 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-12-01

Study Completion Date

2025-12-31

Brief Summary

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CKD-702 is a tetravalent bispecific IgG1 targeting hepatocyte growth factor receptor (MET) and epidermal growth factor receptor (EGFR). The investigators will test a hypothesis that CKD-702 may augment the efficacy of biweekly irinotecan as a 3L or later therapy for gastric cancer overexpressing either MET or EGFR.

Detailed Description

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Conditions

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Gastric Cancer

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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CKD-702 in combination with irinotecan

Group Type EXPERIMENTAL

CKD-702 in combination with irinotecan

Intervention Type DRUG

CKD-702 and irinotecan will be intravenously administered every 2 weeks.

Interventions

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CKD-702 in combination with irinotecan

CKD-702 and irinotecan will be intravenously administered every 2 weeks.

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Failed 2 or more lines of chemotherapy
* Tumor overexpressing either MET or EGFR
* Measurable lesion

Exclusion Criteria

* Prior treatment with anti-MET/EGFR bispecific antibody
Minimum Eligible Age

19 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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National Cancer Center, Korea

OTHER_GOV

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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National Cancer Center

Goyang-si, Gyeonggi-do, South Korea

Site Status RECRUITING

Countries

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South Korea

Central Contacts

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Hark K Kim, MD,PhD

Role: CONTACT

+82-31-920-2238

Facility Contacts

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Hark K Kim, MD,PhD

Role: primary

+82-31-920-2238

Hyegyung Chang, RN

Role: backup

+82-31-920-2233

Other Identifiers

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100945

Identifier Type: -

Identifier Source: org_study_id

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