Improving Tissue Repair After Injury in the Muscle-tendon Interface Muscle Tissue Injury
NCT ID: NCT05746650
Last Updated: 2025-09-24
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
40 participants
INTERVENTIONAL
2023-02-24
2027-09-01
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
BASIC_SCIENCE
TRIPLE
Study Groups
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1) Electrical stimulation + growth hormone
One bout of electrical stimulation with 200 eccentric contractions. This is followed by daily injections with somatropin (33.3 ug/kg in the first week, 50 ug/kg in the second week) for two weeks.
Electrical stimulation
Experimentally induced muscly injury via. neuromuscular electrical stimulation of the hamstring muscles
Growth hormone (somatropin)
Daily injection of growth hormone
2) Electrical stimulation
One bout of electrical stimulation with 200 eccentric contractions
Electrical stimulation
Experimentally induced muscly injury via. neuromuscular electrical stimulation of the hamstring muscles
3) Growth hormone
Daily injections with somatropin (33.3 ug/kg in the first week, 50 ug/kg in the second week) for two weeks.
Growth hormone (somatropin)
Daily injection of growth hormone
4) Control
No intervention
Control (No electrical stimulation, nor growth hormone)
No electrical stimulation, nor growth hormone
Interventions
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Electrical stimulation
Experimentally induced muscly injury via. neuromuscular electrical stimulation of the hamstring muscles
Growth hormone (somatropin)
Daily injection of growth hormone
Control (No electrical stimulation, nor growth hormone)
No electrical stimulation, nor growth hormone
Eligibility Criteria
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Inclusion Criteria
* BMI 18-35
Exclusion Criteria
* Use of corticosteroids in the past 3 months
* Use of any medication known to affect muscle or tendon turnover
* Former participation in a study using deuterated water
* Chronic diseases
18 Years
35 Years
ALL
Yes
Sponsors
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Bispebjerg Hospital
OTHER
Responsible Party
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Grith Højfeldt
Principal Investigator
Principal Investigators
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Grith Højfeldt, PhD
Role: PRINCIPAL_INVESTIGATOR
Institute of Sports Medicine, Bispebjerg Hospital
Locations
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Bispebjerg Hospital
Copenhagen, , Denmark
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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BBH158
Identifier Type: -
Identifier Source: org_study_id
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