Pentosan Polysulfate Treatment's Effectiveness

NCT ID: NCT05744908

Last Updated: 2025-05-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

37 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-01-01

Study Completion Date

2023-01-10

Brief Summary

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To examine the relationship between symptoms and quality of life before and after oral pentosan polysulfate (PPS) treatment in cases diagnosed with interstitial cystitis/painful bladder syndrome (IC/BPS).

Detailed Description

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Demographic characteristics, medical history, clinical conditions, and laboratory and cystoscopic data of patients who applied to our clinic between January 2018 and December 2021 and were diagnosed with IC/BPS were retrospectively analyzed. Adult male and female patients with IC/BPS who received 300 mg/day PPS at least six months ago with complaints of pain, urge, frequency, and nocturia not associated with urinary tract infection were included in the study. In addition, pre- and post-treatment symptoms, ICSI scores, quality of life (scored between 1-4), and satisfaction were compared.

Conditions

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Chronic Interstitial Cystitis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

SEQUENTIAL

two models: with and without Hunner's ulcer
Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Participants

Study Groups

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With Hunner's ulcer

Pentosan Polysulfate 100 mg

Group Type ACTIVE_COMPARATOR

Pentosan Polysulphate

Intervention Type OTHER

300mg 3 times a day

Without Hunner's ulcer

Pentosan Polysulfate 100 mg

Group Type ACTIVE_COMPARATOR

Pentosan Polysulphate

Intervention Type OTHER

300mg 3 times a day

Interventions

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Pentosan Polysulphate

300mg 3 times a day

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Chronic interstitial cystitis
* Bladder Pain Syndrome

Exclusion Criteria

* Acute cystitis
* Bladder cancer
* Chronic prostatitis
* Bladder stone
* Stress incontinence
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Hisar Intercontinental Hospital

OTHER

Sponsor Role lead

Responsible Party

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Basri Cakiroglu

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Basri Cakiroglu

Istanbul, , Turkey (Türkiye)

Site Status

Hisar Intercontinental Hospital

Istanbul, , Turkey (Türkiye)

Site Status

Countries

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Turkey (Türkiye)

Other Identifiers

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10.01.2023/37

Identifier Type: -

Identifier Source: org_study_id

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