NLRP3 Inflammasome Activation Among Patients During Acute Gout Flares

NCT ID: NCT05744297

Last Updated: 2023-05-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

10 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-04-28

Study Completion Date

2023-10-31

Brief Summary

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Gout is a chronic joint disease associated with deposition of monosodium urate crystals, as a consequence of hyperuricemia. Gout is an intermittent flaring condition and acute gout flares are driven by NLRP3 inflammasome and IL1-beta production.

However pathogenesis of acute gout flares remains poorly known in vivo in human.

The aim of this study is to evaluate NLRP3 inflammasome activation in vivo in patients cells during acute gout flares.

Detailed Description

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Blood and synovial fluid will be obtained from remainder of patients' samples during an acute gout flares. White blood cells will be isolated and NLRP3 inflammasome activation will be assessed. Then, NLRP3 inflammasome inhibitors will be tested on cells with NLRP3 inflammasome activity.

Conditions

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Gout Arthritis

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Hospitalization for acute gout flare confirmed by joint fluid analysis or Nijmegen score \> 8
* Aged \> 18

Exclusion Criteria

* Gout treatment already started
* Inflammatory Arthritis other than Gout Arthritis
* Pregnant or breast feeding women
* Patient protected by law
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Centre Hospitalier Saint Joseph Saint Luc de Lyon

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Centre Hospitalier Saint Joseph Saint Luc

Lyon, , France

Site Status RECRUITING

Countries

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France

Central Contacts

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Julien Seiller, MD

Role: CONTACT

478 617 757 ext. +33

Facility Contacts

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Julien Seiller, MD

Role: primary

Other Identifiers

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ActiNG

Identifier Type: -

Identifier Source: org_study_id

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