Evaluation of Regional Ventilation Distribution in Patients Affected by Abdominal Sepsis After Emergent Laparotomy
NCT ID: NCT05726500
Last Updated: 2023-02-14
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
30 participants
INTERVENTIONAL
2023-02-15
2024-12-31
Brief Summary
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• evaluate if patients admitted after an open abdomen strategy have a different regional ventilation distribution compared to patients in which abdomen is closed at the end of the procedure
Participants will undergo non-invasive monitoring (esophageal pressure and electrical impedance tomography) and an blood gas analysis samples.
Researchers will compare open abdomen group and closed abdomen group to see if the ventilation distribution pattern is different.
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Detailed Description
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Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
PREVENTION
NONE
Study Groups
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Open Abdomen
Arterial blood gas analysis
The researches will collect 2 ml of arterial blood using an arterial line already in place for clinical purposes to perform and arterial gas analysis.
Venous blood gas analysis
The researches will collect 2 ml of arterial blood using a central venous line already in place for clinical purposes to perform a gas analysis.
Esophageal pressure monitoring
The researchers will position an esophageal balloon to evaluate esophageal pressure
Intrabdominal pressure
The researches will assess intrabdominal pressure using the urinary catheter system already in place for clinical purposes .
Electrical impedance tomopgraphy
The researches will evaluate regional ventilation distribution using Electrical impedance tomography at different levels of positive end-expiratory pressure
Closed Abdomen
Arterial blood gas analysis
The researches will collect 2 ml of arterial blood using an arterial line already in place for clinical purposes to perform and arterial gas analysis.
Venous blood gas analysis
The researches will collect 2 ml of arterial blood using a central venous line already in place for clinical purposes to perform a gas analysis.
Esophageal pressure monitoring
The researchers will position an esophageal balloon to evaluate esophageal pressure
Intrabdominal pressure
The researches will assess intrabdominal pressure using the urinary catheter system already in place for clinical purposes .
Electrical impedance tomopgraphy
The researches will evaluate regional ventilation distribution using Electrical impedance tomography at different levels of positive end-expiratory pressure
Interventions
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Arterial blood gas analysis
The researches will collect 2 ml of arterial blood using an arterial line already in place for clinical purposes to perform and arterial gas analysis.
Venous blood gas analysis
The researches will collect 2 ml of arterial blood using a central venous line already in place for clinical purposes to perform a gas analysis.
Esophageal pressure monitoring
The researchers will position an esophageal balloon to evaluate esophageal pressure
Intrabdominal pressure
The researches will assess intrabdominal pressure using the urinary catheter system already in place for clinical purposes .
Electrical impedance tomopgraphy
The researches will evaluate regional ventilation distribution using Electrical impedance tomography at different levels of positive end-expiratory pressure
Eligibility Criteria
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Inclusion Criteria
* Admitted to the ICU after emergent laparotomy for abdominal sepsis
* Acute respiratory failure
Exclusion Criteria
* body mass index \> 40 kg/m2
* Haemodinamic instability
* Pneumothorax - Pneumomediastinum
* refusal to participate
18 Years
90 Years
ALL
No
Sponsors
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University of Milan
OTHER
Università degli Studi di Ferrara
OTHER
Responsible Party
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Savino Spadaro
Principal investigator
Locations
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Azienda Ospedaliero Universitaria Sant'Anna
Ferrara, , Italy
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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CHESTOMY
Identifier Type: -
Identifier Source: org_study_id
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