Familial B-cell Lymphoproliferative Disorders

NCT ID: NCT05718986

Last Updated: 2024-05-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Total Enrollment

1000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-06-30

Study Completion Date

2040-12-31

Brief Summary

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This study investigates families with at least two cases of B-cell lymphoproliferative disorders (LPD), and evaluates the prevalence of LPD in families, the relationship between medical history, genetic factors, and the risk of familial LPD, and various clinical outcomes for these families in a multiethnic population of Jews and Arabs in Israel.

Detailed Description

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Conditions

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Lymphoproliferative Disorders Premalignant Monoclonal B-Cell Lymphocytosis Chronic Lymphocytic Leukemia

Study Design

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Observational Model Type

FAMILY_BASED

Study Time Perspective

OTHER

Study Groups

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Bnai Zion Medical Center

Bnai Zion Medical Center

No intervention

Intervention Type OTHER

No intervention

Tel Aviv Sourasky Medical Center - Ichilov Hospital

Tel Aviv Sourasky Medical Center - Ichilov Hospital

No intervention

Intervention Type OTHER

No intervention

Galil Medical Center

Galil Medical Center

No intervention

Intervention Type OTHER

No intervention

Ziv Medical Center

Ziv Medical Center

No intervention

Intervention Type OTHER

No intervention

Emek Medical Center

Emek Medical Center

No intervention

Intervention Type OTHER

No intervention

Beilinson Hospital

Beilinson Hospital

No intervention

Intervention Type OTHER

No intervention

Meir Medical Center

Meir Medical Center

No intervention

Intervention Type OTHER

No intervention

Kaplan Medical Center

Kaplan Medical Center

No intervention

Intervention Type OTHER

No intervention

Sheba Medical Center

Sheba Medical Center

No intervention

Intervention Type OTHER

No intervention

Rambam Medical Center

Rambam Medical Center

No intervention

Intervention Type OTHER

No intervention

Shaare Zdek Medical Center

Shaare Zdek Medical Center

No intervention

Intervention Type OTHER

No intervention

Hadassah Medical Center

Hadassah Medical Center

No intervention

Intervention Type OTHER

No intervention

Shamir Medical Center (Assaf Harofeh)

Shamir Medical Center (Assaf Harofeh)

No intervention

Intervention Type OTHER

No intervention

Soroka Medical Center

Soroka Medical Center

No intervention

Intervention Type OTHER

No intervention

Assuta Ashdod Hospital

Assuta Ashdod Hospital

No intervention

Intervention Type OTHER

No intervention

Interventions

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No intervention

No intervention

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

Patients must have LPD and must have a family history of LPD. LPD patients who signed an informed consent to participate in the study.

Criteria for the inclusion of relatives of patients:

Relatives must be related by blood to LPD patients or unrelated (for control group).

Relatives who signed an informed consent to participate in the study.

Exclusion Criteria

* Pregnant women, special populations and those lacking judgment will not be included
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Bnai Zion Medical Center

OTHER_GOV

Sponsor Role collaborator

University of Haifa

OTHER

Sponsor Role lead

Responsible Party

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Geffen Kleinstern

Senior Lecturer

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Geffen Kleinstern, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Haifa

Central Contacts

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Geffen Kleinstern, PhD

Role: CONTACT

+972545715624

Tamar Tadmor, MD

Role: CONTACT

Other Identifiers

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FamilialLPD

Identifier Type: -

Identifier Source: org_study_id

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