Metabolic Effects of Early Time-restricted Carbohydrate Consumption

NCT ID: NCT05713058

Last Updated: 2023-08-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

27 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-03-01

Study Completion Date

2023-06-30

Brief Summary

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In this clinical trial, the investigators aim to examine the impact of a 12-week early time-restricted carbohydrate consumption diet on weight loss and glucose metabolism in patients with overweight/obesity and type 2 diabetes

Detailed Description

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Conditions

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Diabetes Mellitus, Type 2 Obesity Nutrition, Healthy Weight Loss

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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eTRC diet

Group Type EXPERIMENTAL

eTRC diet

Intervention Type BEHAVIORAL

12-week dietary prescription with moderate energy restriction (approximately 200 kcal/day) focusing on the distribution of macronutrients within the day so as to avoid carbohydrate consumption after lunch

Control diet

Group Type ACTIVE_COMPARATOR

Control diet

Intervention Type BEHAVIORAL

12-week dietary prescription with moderate energy restriction (approximately 200 kcal/day) without any recommendations on the distribution of macronutrients within the day

Interventions

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eTRC diet

12-week dietary prescription with moderate energy restriction (approximately 200 kcal/day) focusing on the distribution of macronutrients within the day so as to avoid carbohydrate consumption after lunch

Intervention Type BEHAVIORAL

Control diet

12-week dietary prescription with moderate energy restriction (approximately 200 kcal/day) without any recommendations on the distribution of macronutrients within the day

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* age 18-75 years
* both males and females
* type 2 diabetes

Exclusion Criteria

* type 1 diabetes
* insulin treatment
* pharmacological treatment for weight loss
* pregnancy
* other acute or chronic conditions influencing body weight and glucose metabolism
Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Azienda Ospedaliero, Universitaria Pisana

OTHER

Sponsor Role lead

Responsible Party

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Andrea Natali

Full Professor of Nutrition

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Andrea Natali, MD

Role: PRINCIPAL_INVESTIGATOR

University of Pisa

Locations

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Azienda Ospedaliero-Universitaria Pisana

Pisa, PI, Italy

Site Status

Countries

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Italy

References

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Trico D, Masoni MC, Baldi S, Cimbalo N, Sacchetta L, Scozzaro MT, Nesti G, Mengozzi A, Nesti L, Chiriaco M, Natali A. Early time-restricted carbohydrate consumption vs conventional dieting in type 2 diabetes: a randomised controlled trial. Diabetologia. 2024 Feb;67(2):263-274. doi: 10.1007/s00125-023-06045-9. Epub 2023 Nov 16.

Reference Type DERIVED
PMID: 37971503 (View on PubMed)

Other Identifiers

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eTRC DIET

Identifier Type: -

Identifier Source: org_study_id

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