Study Results
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Basic Information
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RECRUITING
600 participants
OBSERVATIONAL
2018-02-01
2030-12-31
Brief Summary
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In parallel to the studies of recovery, studies on time series of biomarkers after stroke are limited (2). Hence, a crucial first step to increase knowledge on biomarkers of stroke recovery is to gain a better understanding of the time course of both stroke recovery and biomarker patterns. Biomarkers can later be used for outcome predictions after stroke.
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Detailed Description
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Stroke survivors frequently suffer disabilities including motor and cognitive problems, impairments in speech and vision, depression, and several other disabilities that worsen their quality of life. Some will recover fully after stroke and others will have permanent impairements. Few studies show trajectories of recovery in different domains after stroke, hence recovery time-lines are not fully known. Also, the whole range of mechanisms leading to recovery are not precisely known (1). To monitor those mechanisms one can utilize biomarkers.
In parallel to the studies of recovery, studies on time series of biomarkers after stroke are limited (2). Hence, a crucial first step to increase knowledge on biomarkers of stroke recovery is to gain a better understanding of the time course of both stroke recovery and biomarker patterns. Biomarkers can later be used for outcome predictions after stroke.
WORK PLAN
AIM Determine temporal profiles describing the speed, order, and degree of recovery in neurological and cognitive functions in various domains with simultaneous profiling of changes in blood biomarker concentrations, in the acute, subacute phases and long-term of stroke. Determine individual and interindividual variations in recovery in the different domains.
Informed consent Written informed consent will be obtained from all willing participants or their next-of-kin.
Conditions
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Study Design
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CASE_ONLY
PROSPECTIVE
Study Groups
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Observational - all
All included stroke patients.
Observational - all
All stroke patients are included.
Interventions
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Observational - all
All stroke patients are included.
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* severe neurodegenerative disease, cerebral neoplasm or terminal illness; and
* patients considered unlikely to be able to participate in or to understand and/or comply with study procedures during follow-up visits at the hospital.
18 Years
ALL
No
Sponsors
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Göteborg University
OTHER
Responsible Party
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Principal Investigators
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Christina Jern, MD, PhD
Role: PRINCIPAL_INVESTIGATOR
Inst. of Biomedicine, the Sahlgrenska Academy, Univ. of Gothenburg
Turgut Tatlisumak, MD, PhD
Role: PRINCIPAL_INVESTIGATOR
Dept. of Neurology, Sahlgrenska Univ. Hosp., Gothenburg
Katarina Jood, MD, PhD
Role: PRINCIPAL_INVESTIGATOR
Dept. of Neurology, Sahlgrenska Univ. Hosp., Gothenburg
Locations
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Department of Neurology, Department of Neurorehabilitation and Department of Clinical Genetics, Sahlgrenska University Hospital
Gothenburg, , Sweden
Countries
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Central Contacts
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Facility Contacts
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References
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Wieloch T, Nikolich K. Mechanisms of neural plasticity following brain injury. Curr Opin Neurobiol. 2006 Jun;16(3):258-64. doi: 10.1016/j.conb.2006.05.011. Epub 2006 May 18.
Doll DN, Barr TL, Simpkins JW. Cytokines: their role in stroke and potential use as biomarkers and therapeutic targets. Aging Dis. 2014 Oct 1;5(5):294-306. doi: 10.14336/AD.2014.0500294. eCollection 2014 Oct.
Brannmark C, Klasson S, Stanne TM, Samuelsson H, Alt Murphy M, Sunnerhagen KS, Aberg ND, Jalnefjord O, Bjorkman-Burtscher I, Jood K, Tatlisumak T, Jern C. FIND Stroke Recovery Study (FIND): rationale and protocol for a longitudinal observational cohort study of trajectories of recovery and biomarkers poststroke. BMJ Open. 2023 May 10;13(5):e072493. doi: 10.1136/bmjopen-2023-072493.
Other Identifiers
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FIND
Identifier Type: -
Identifier Source: org_study_id
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