Peer Engagement in Methamphetamine Harm-Reduction With Contingency Management (PEER-CM)

NCT ID: NCT05700994

Last Updated: 2026-01-14

Basic Information

• Recruitment Status: ACTIVE_NOT_RECRUITING
• Clinical Phase: NA
• Total Enrollment: 1283 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2023-11-13
• Study Completion Date: 2026-09-30

Brief Summary

The main goal of this study is to tests the effect of incentivizing achievement of self-identified, personal harm reduction goals (Contingency management or CM) compared with standard of care (peer harm reduction service with incentives for peer visits) to increase the reach and effectiveness of methamphetamine (MA) harm reduction services.

Detailed Description

Using a hybrid type 1 effectiveness-implementation framework and stepped-wedge design, this study will randomize eighteen community-based peer harm reduction sites to provide contingency management incentives for achieving self-identified harm reduction goals set with peer specialists using a participant-driven harm reduction goal-setting process (e.g. completing overdose prevention and supply training, daily life goals, treatment and care goals, relationship and social support goals) versus standard of care contingency management (i.e. incentives for peer encounter attendance).

Conditions

Methamphetamine Abuse

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: SEQUENTIAL
• Primary Study Purpose: SUPPORTIVE_CARE
• Blinding Strategy: NONE

Study Groups

PEER-CM

Peer-facilitated contingency management (PEER-CM).

Group Type: EXPERIMENTAL

Peer Contingency Management

Intervention Type: BEHAVIORAL

Participants allocated to peer-facilitated contingency management will receive incentives for achieving self-identified harm reduction goals set with peer specialists using a participant-driven harm reduction goal-setting process (e.g. completing overdose prevention and supply training, daily life goals, treatment and care goals, relationship and social support goals)

Standard of Care

Standard of care contingency management.

Group Type: ACTIVE_COMPARATOR

Standard of Care Contingency Management

Intervention Type: BEHAVIORAL

Participants allocated to standard of care contingency management will receive incentives for peer encounters.

Interventions

Peer Contingency Management

Participants allocated to peer-facilitated contingency management will receive incentives for achieving self-identified harm reduction goals set with peer specialists using a participant-driven harm reduction goal-setting process (e.g. completing overdose prevention and supply training, daily life goals, treatment and care goals, relationship and social support goals)

Intervention Type: BEHAVIORAL

Standard of Care Contingency Management

Participants allocated to standard of care contingency management will receive incentives for peer encounters.

Intervention Type: BEHAVIORAL

Other Intervention Names

PEER-CM; Standard of Care

Eligibility Criteria

Inclusion Criteria

This intervention is at the site level. Community-based organization sites are eligible if they:

• Use peer support specialists to provide direct outreach and harm reduction services to people who use drugs
• Are willing to be trained in the two strategies for peer-facilitated contingency management

Clients who:

• Age 18 and older
• Any stimulant (methamphetamine, cocaine) use in the past 30 days
• Willing to accept peer services
• Willing to complete initial and follow-up assessments with peer
• Able to communicate in English or Spanish

Exclusion Criteria

Community-based organization sites who:

• Do not use peer support specialists to provide direct outreach and harm reduction services to people who use drugs
• Are not willing to be trained in the two strategies for peer-facilitated contingency management

Clients who:

• Present any danger or threat of violence to peers

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 105 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Comagine Health

OTHER

Sponsor Role: collaborator

Oregon Health Authority

OTHER

Sponsor Role: collaborator

Oregon Health and Science University

OTHER

Sponsor Role: lead

Responsible Party

P. Todd Korthuis, MD

Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Comagine Health

Portland, Oregon, United States

Oregon Health & Science University

Portland, Oregon, United States

Countries

United States

References

Cooke A, Stack E, Peng L, Cook R, Hartzler B, Leichtling G, Hildebran C, Leahy JM, Payne KS, Kunkel LE, Hoffman K, Korthuis PT. The peers expanding engagement in stimulant harm reduction with contingency management study: a protocol paper. Addict Sci Clin Pract. 2025 Jun 10;20(1):48. doi: 10.1186/s13722-025-00577-8.

Reference Type: DERIVED

PMID: 40495203 (View on PubMed)

Peng L, Stack E, Cooke A, Hartzler B, Cook R, Leichtling G, Hildebran C, Leahy J, Payne KS, Kunkel L, Hoffman K, Korthuis PT. Centering peers in design and training for a peer-delivered contingency management program for self-identified harm reduction and treatment goals. Harm Reduct J. 2025 May 6;22(Suppl 1):72. doi: 10.1186/s12954-025-01213-z.

Reference Type: DERIVED

PMID: 40329274 (View on PubMed)

Other Identifiers

PEER-CM

Identifier Type: -

Identifier Source: org_study_id