Prediction of Hypotension During Cesarean Delivery Using Positional Change of Hemodynamic Parameters

NCT ID: NCT05685212

Last Updated: 2023-10-02

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 121 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2023-04-01
• Study Completion Date: 2023-08-30

Brief Summary

This was a prospective observational study between January 2022 and June 2022. The investigators included parturients aged 18 to 45 years, consenting, classified ASA II and III, scheduled for elective or emergency cesarean section (Lucas III-IV). Baseline hemodynamic parameters were measured in 3 different positions: sitting, supine, and left lateral tilt 15°. The investigators defined Δ1 as the change from the sitting position to the supine position ad Δ2 as the change from the left lateral tilt 15° position to the supine position. Our primary endpoint was the incidence of hypotension defined as a decrease of more than 20% from baseline values. The investigators performed univariate and then multivariate analysis.

Detailed Description

The investigators conducted a monocentric prospective observational study between January 2022 and June 2022, in the maternity unit of Mongi Slim University Hospital in Tunisia. The investigators aimed to have a population that is representative of all parturients scheduled for cesarean section, thereby they included American Society of Anesthesiologists physical status I and II parturients aged 18 to 45 at term and scheduled for either elective cesarean section or emergency cesarean section (Lucas III-IV).

The investigators chose hypotension as the primary endpoint, defined as a decrease in SAP of more than 20% of the baseline values. Secondary endpoints included total dose of ephedrine, incidence of symptomatic hypotension defined as hypotension plus nausea and/or vomiting and/or dizziness, time to onset of hypotension, duration of hypotension, and the use of rescue bolus of norepinephrine.

The investigators tried to standardize the anesthetic management. Parturients were monitored with a three-lead electrocardiogram, non-invasive arterial pressure, pulse oximetry, and capnography through a facial mask. Baseline maternal hemodynamic parameters were measured 3 times at 1-minute interval in three different positions: consecutively sitting position, supine position, and left lateral tilt 15° position. Spinal anesthesia was performed in the sitting position in the L3-L4 or L4-L5 vertebral interspace. Patients received doses of local anesthetic weighted to their height. Patients were co-loaded with an infusion of normal saline using a pressurized bad. Hypotension was treated with IV bolus of ephedrine in increments of 6 mg. If hypotension persisted or reoccurred after the patient had already received 60 mg of ephedrine, The investigators resorted to rescue bolus of norepinephrine in increments of 5 µg. After child delivery, patients received a standard dose of 10 IU of oxytocin, additional doses were added if the obstetrician requested it.

The investigators collected data regarding demographic characteristics, obstetric characteristic, anesthetic management, and details about the hypotensive event.

Conditions

Cesarean Section; Hypotension; Anesthesia, Spinal; Heart Rate; Blood Pressure

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: PROSPECTIVE

Study Groups

Group Hypotension.

patients who developed hypotension defined as a decrease in systolic arterial pressure more than 20% of the baseline

No interventions assigned to this group

Group Normotension

patients who did not experience a hypotensive event.

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

• American society of anesthesiologists' (ASA) physical status of II-III.
• Full-term pregnancy.
• Elective cesarean section.
• Emergency cesarean section (Lucas III-IV).

Exclusion Criteria

• Emergency cesarean section (Lucas I-II).
• Cesarean section under epidural anesthesia.
• Patients with abnormal placentation.
• Patients with contraindication for spinal anesthesia.
• Patients with personal medical history of cardiac arrythmias or valvular heart disease.
• Patients on beta-blockers.
• Failed spinal anesthesia.
• Conversion to general anesthesia.
• Postpartum hemorrhage.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 45 Years
• Eligible Sex: FEMALE
• Accepts Healthy Volunteers: No

Sponsors

Mongi Slim Hospital

OTHER

Sponsor Role: lead

Responsible Party

Mhamed Sami Mebazaa

Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Faten Haddad

Role: PRINCIPAL_INVESTIGATOR

Mongi Slim local research ethical committee

Locations

Mongi Slim University Hospital

La Marsa, Tunis Governorate, Tunisia

Countries

Tunisia

Other Identifiers

hypotension Cesarean section

Identifier Type: -

Identifier Source: org_study_id