Detection of Jaundice From Ocular Images Via Deep Learning

NCT ID: NCT05682105

Last Updated: 2023-01-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

1633 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-12-01

Study Completion Date

2023-06-30

Brief Summary

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Our study presents a detection model predicting a diagnosis of jaundice (clinical jaundice and occult jaundice) trained on prospective cohort data from slit-lamp photos and smartphone photos, demonstrating the model's validity and assisting clinical workers in identifying patient underlying hepatobiliary diseases.

Detailed Description

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This study demonstrated that deep learning models could detect jaundice using ocular images in blood levels with reasonable accuracy, providing a non-invasive method for jaundice detection and recognition. This algorithm can assist clinical surgeons with daily follow-up visits and provide referral advice. It also highlights the algorithm's potential smartphone application in sizeable real-world population-based disease-detecting or telemedicine programs.

Conditions

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Ophthalmology Artificial Intelligence Hepatobiliary Disease

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Development dataset

Slit-lamp images collected from the Department of Hepatobiliary Surgery of the Third Affiliated Hospital of Sun Yat-sen University(HTH), Affiliated Huadu Hospital of Southern Medical University(HDH), and Nantian Medical Centre of Aikang Health Care (NMC).

No interventions assigned to this group

Testing dataset

Slit-lamp and smartphone images collected from the Department of Infectious Diseases, Third Affiliated Hospital of Sun Yat-sen University(ITH), Huanshidong Medical Centre of Aikang Health Care, the Medical Centre of the Third Affiliated Hospital of Sun Yat-sen University(MCH).

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* The quality of slit-lamp images should be clinical acceptable. More than 90% of the slit-lamp image area, including three central regions (sclera, pupil, and lens) are easy to read and discriminate.

Exclusion Criteria

* Images with light leakage (\>10% of the area), spots from lens flares or stains, and overexposure were excluded from further analysis
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Third Affiliated Hospital, Sun Yat-Sen University

OTHER

Sponsor Role collaborator

Affiliated Huadu Hospital of Southern Medical University

UNKNOWN

Sponsor Role collaborator

Aikang Health Care

UNKNOWN

Sponsor Role collaborator

Sun Yat-sen University

OTHER

Sponsor Role lead

Responsible Party

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Haotian Lin

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Zhongshan Ophthalmic Center

Guangzhou, Guangdong, China

Site Status

Countries

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China

Other Identifiers

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AEHD-2022

Identifier Type: -

Identifier Source: org_study_id

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