Screening and Identifying Hepatobiliary Diseases Via Deep Learning Using Ocular Images

NCT ID: NCT04213183

Last Updated: 2020-08-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

1789 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-12-01

Study Completion Date

2020-01-31

Brief Summary

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Artificial Intelligence may provide insight into exploring the potential covert association behind and reveal some early ocular architecture changes in individuals with hepatobiliary disorders. We conducted a pioneer work to explore the association between the eye and liver via deep learning, to develop and evaluate different deep learning models to predict the hepatobiliary disease by using ocular images.

Detailed Description

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Conditions

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Ophthalmology Artificial Intelligence Hepatobiliary Disease

Study Design

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Observational Model Type

OTHER

Study Time Perspective

PROSPECTIVE

Study Groups

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development dataset 01

Slit-lamp and retinal fundus images collected from Department of Hepatobiliary Surgery of the Third Affiliated Hospital of Sun Yat-sen University.

Hepatobiliary Disorders

Intervention Type DIAGNOSTIC_TEST

The training dataset was used to train the deep learning model, which was validated and tested by the other two datasets.

development dataset 02

Slit-lamp and retinal fundus images collected from Affiliated Huadu Hospital of Southern Medical University.

Hepatobiliary Disorders

Intervention Type DIAGNOSTIC_TEST

The training dataset was used to train the deep learning model, which was validated and tested by the other two datasets.

development dataset 03

Slit-lamp and retinal fundus images collected from Nantian Medical Centre of Aikang Health Care.

Hepatobiliary Disorders

Intervention Type DIAGNOSTIC_TEST

The training dataset was used to train the deep learning model, which was validated and tested by the other two datasets.

test dataset 01

Slit-lamp and retinal fundus images collected from Department of Infectious Diseases, Third Affiliated Hospital of Sun Yat-sen University.

Hepatobiliary Disorders

Intervention Type DIAGNOSTIC_TEST

The training dataset was used to train the deep learning model, which was validated and tested by the other two datasets.

test dataset 02

Slit-lamp and retinal fundus images collected from Huanshidong Medical Centre of Aikang Health Care.

Hepatobiliary Disorders

Intervention Type DIAGNOSTIC_TEST

The training dataset was used to train the deep learning model, which was validated and tested by the other two datasets.

Interventions

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Hepatobiliary Disorders

The training dataset was used to train the deep learning model, which was validated and tested by the other two datasets.

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* The quality of fundus and slit-lamp images should clinical acceptable.
* More than 90% of the fundus image area including four main regions (optic disk, macular, upper and lower retinal vessel archs) are easy to read and discriminate.
* More than 90% of the slit-lamp image area including three main regions (sclera, pupil, and lens) are easy to read and discriminate.

Exclusion Criteria

* Images with light leakage (\>10% of the area), spots from lens flares or stains, and overexposure were excluded from further analysis.
Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Third Affiliated Hospital, Sun Yat-Sen University

OTHER

Sponsor Role collaborator

Affiliated Huadu Hospital of Southern Medical University

UNKNOWN

Sponsor Role collaborator

Aikang Health Care

UNKNOWN

Sponsor Role collaborator

Sun Yat-sen University

OTHER

Sponsor Role lead

Responsible Party

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Haotian Lin

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Zhongshan Ophthalmic Center, Sun Yat-sen Univerisity

Guangzhou, Guangdong, China

Site Status

Countries

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China

Other Identifiers

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AEHD-2019

Identifier Type: -

Identifier Source: org_study_id

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