Evaluation of the Effect of Self-Assembling Peptide P11-4
NCT ID: NCT05667545
Last Updated: 2023-01-06
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
PHASE1
30 participants
INTERVENTIONAL
2021-07-01
2021-10-30
Brief Summary
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These tissues have poor regeneration capability because of the lack of both regenerative cells and vascularization.
In the complex caries progression process involving dietary sugars, bacterial metabolism and demineralization, the collagenous organic matrix becomes exposed and destroyed by resident and bacterial proteases, allowing the lesion to expand
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Detailed Description
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However, when caries progresses to the point of breaking down the dental tissues, composite restorations are imperative to preserve the tooth functionality.
During the execution of routine dental restorations, the hybrid structure formed by the dental bonding procedure occurs through the interaction and subsequent polymerization of monomers around the demineralized collagen matrix.
The oral cavity is a severe environment for the resin-dental bond to survive for a reasonable length of time, with thermomechanical changes, chemical attacks by acids and enzymes and other factors posing routine daily challenges. Therefore to achieve effective and stable bonding, the preservation of dentin collagen is critical, since collagen represents the major organic component of the dentin matrix.
Based on today's understanding of the dental biomineralization process, new efforts have been made to develop synthetic analogues of non-collagenous proteins (NCPs), which are involved in the events of nucleation and growth of hydroxyapatite crystals in hard tissues Such analogues have been designed mirroring the amphiphilic characteristics of NCPs, with polar groups complexing inorganic ions and non-polar side chains governing the matrix-matrix interactions.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
SINGLE
Study Groups
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Negative control group (A1)
A1: cavities will be sealed directly by restorative material (conventional glass ionomer) without any treatment.
Peptide
it is about synthetic protein acting on tooth structure help information apatite crystals
Treatment group (A2)
A2: cavities will be treated by Self-Assembling peptide P11-4 then sealed by conventional glass ionomer.
Peptide
it is about synthetic protein acting on tooth structure help information apatite crystals
Interventions
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Peptide
it is about synthetic protein acting on tooth structure help information apatite crystals
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Age of patient: 18 -30 years
* Carious lesions will be standardized by means of clinical and radiographic examinations performed before the procedures
Exclusion Criteria
* Developmental disorders and adjacent soft tissue lesions
* Patients with systemic illness will be excluded
18 Years
30 Years
ALL
No
Sponsors
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Egymedicalpedia
INDUSTRY
Responsible Party
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Principal Investigators
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Asmaa Mosleh, Lecturer
Role: PRINCIPAL_INVESTIGATOR
Al-Azhar Faculty of Dentistary for girls
Locations
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Faculty of Dentistary - Al-Azhar University
Cairo, , Egypt
Countries
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Other Identifiers
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Nafesa Mostafa
Identifier Type: -
Identifier Source: org_study_id
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