R-3750 in Patients With Mild to Moderate Ulcerative Colitis
NCT ID: NCT05666960
Last Updated: 2025-03-24
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
PHASE1
36 participants
INTERVENTIONAL
2023-02-27
2025-10-31
Brief Summary
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Patients will take an oral dosage of probiotic (R-3750) and provide patient-reported and physician scored measures of their colitis. Blood and fecal evaluations of inflammation and assessment of probiotic (R-3750) on fecal levels will also be measured.
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Detailed Description
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Conditions
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Study Design
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NA
SINGLE_GROUP
TREATMENT
NONE
Interventions
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R-3750
Probiotic
Eligibility Criteria
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Inclusion Criteria
* Ability to provide written informed consent
* Confirmed diagnosed with UC by colonoscopy and histology and suffering from mild to moderate UC as defined by MMDAI with score of 3-9
* On a stable dose of aminosalicylate (i.e. no change in medication within 4 weeks of study enrollment) and not planning to initiate new medication other than the study drug
* For women of childbearing potential or men with a partner of childbearing potential, agree to use birth control methods (including hormonal contraceptives, intrauterine device (IUD) or hormone releasing system (IUS), vasectomy) and men will refrain from donating sperm during the study and at least 30 days after dosing (per FDA guidelines)
* For the expansion cohort, a flexible sigmoidoscopy is required, unless an endoscopy was completed within 3 months from enrollment is available
* Refrain from receiving any type of vaccinations during the study period (to include but not limited to influenza, COVID, shingles, tetanus, hepatitis, pneumonia, HPV, DPT, MMR, and polio)
Exclusion Criteria
* Evidence of severe UC disease (MMDAI score greater than or equal to 10)
* Evidence of any active or recent infection including chronic infectious disease such as Hepatitis B, C, or HIV
* Evidence of any active or recent chronic chest infection with bronchiectasis or sinusitis, or covid-19 infection in the past 3 months
* Treatment with immunosuppressants or anti-cancer drugs, e.g., anti-TNF-α agents, anti-integrin agents, azathioprine or 6-MP, 6-thioguanine, methotrexate, ozanimod, tofacitinid, upadacitinib, tacrolimus, cyclophosphamide, or cyclosporine or any other therapy that is not an aminosalicylate within the last 3 months
* Received an investigational drug within 3 months (or 5 half-lives, whichever is longer) before study entry
* Use of steroidal drugs to treat UC (e.g., prednisone \>20 mg/day)
* Use of probiotics within the last one (1) week and during the trial.
* Treatment with systemic broad-spectrum antibiotics in the past 2 months
* Major active systemic autoimmune disease other than UC
* History of anaphylaxis or allergies to probiotics
* History of alcohol or drug abuse within the past 2 years
* History of stroke, or any cerebrovascular disease requiring medication/treatment
* History of cancer, apart from successfully treated basal cell carcinoma or in situ carcinoma of the cervix \>1 year prior to enrollment
* Significant laboratory abnormalities, including liver transaminases (AST or ALT) \> 1.5X the upper limit of normal.
* Second degree or higher heart block or clinically significant arrythmia
* Any other clinically significant renal, hepatic, hematological or other disease or laboratory abnormality which, in the opinion of the investigator, would interfere with the conduct, the interpretation of the safety signals or results of the trial, or would place the subject at unacceptable risk
* Any condition or circumstance that, in the opinion of the Principal Investigator, would compromise the safety of the subject or the quality of study data
18 Years
65 Years
ALL
No
Sponsors
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Mayo Clinic
OTHER
University of Colorado, Denver
OTHER
Rise Therapeutics LLC
INDUSTRY
Responsible Party
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Locations
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AP Medical Research LLC
Miami, Florida, United States
Edward Jenner Research Group, LLC
Plantation, Florida, United States
Mayo Clinic
Rochester, Minnesota, United States
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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RISE R-3750-01
Identifier Type: -
Identifier Source: org_study_id
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