Accelerated Age-related Cognitive Decline: Impact of Exercise on Executive Function and Neuroplasticity
NCT ID: NCT05655325
Last Updated: 2025-03-14
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
144 participants
INTERVENTIONAL
2024-06-18
2027-02-01
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
DOUBLE
Study Groups
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Home-based walking exercise
A 6-month partially supervised walking exercise training using a tapered approach. Participants begin with exercising (walking) in person, on-site one time per week and 3 times per week at home for a minimum exercise dosage of 30 minutes of accumulated exercise per session during month 1. During month 2, participants will exercise on-site once every other week and 3-4 times per week at home a minimum exercise dosage of 30 minutes of accumulated exercise per session. During months 2-6, participants will exercise at home 4 times per week for a minimum exercise dosage of 30 minutes of accumulated exercise per session and they will receive a phone call every two weeks to help coach and address any problems. Participants will receive a Fitbit fitness tracker that will be used to deliver their personalized exercise program, exercise monitoring, feedback, and motivational messages.
Home-based walking exercise
A 6-month partially supervised walking exercise program using a tapered approach.Participants will begin exercise (walking) at a relatively low intensity and progress to moderate intensity. Intensity will start at 40% and progress as tolerated up to 60-70%. Rating of perceived exertion of 12-14 (fairly light to moderate) will be used to aid intensity (Rating of perceived exertion 6-20 scale). This is an accepted method for achieving desired exercise intensity. Participants will progress over time to exercise 3-4/week for 30-45 minutes. The exercise program may need to be adjusted for (e.g. 10 minutes of exercise 3 times), to achieve the minimum exercise dose of 30 minutes. This will be determined for each individual participants as needed.
Health education
The health education group will receive the same amount of contact hours as the intervention group. The attention control group will receive health education and stretching exercises. Participants will be in person, on-site one time per week during month 1 for about 30 minutes. During month 2, participants will attend the health education on-site once every other week for about 30 minutes. During months 2-6 participants will receive a phone call every two weeks to help remind about the health education. Participants will receive a Fitbit fitness tracker that will be used for exercise monitoring.
Attention control
Health education and stretching
Interventions
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Home-based walking exercise
A 6-month partially supervised walking exercise program using a tapered approach.Participants will begin exercise (walking) at a relatively low intensity and progress to moderate intensity. Intensity will start at 40% and progress as tolerated up to 60-70%. Rating of perceived exertion of 12-14 (fairly light to moderate) will be used to aid intensity (Rating of perceived exertion 6-20 scale). This is an accepted method for achieving desired exercise intensity. Participants will progress over time to exercise 3-4/week for 30-45 minutes. The exercise program may need to be adjusted for (e.g. 10 minutes of exercise 3 times), to achieve the minimum exercise dose of 30 minutes. This will be determined for each individual participants as needed.
Attention control
Health education and stretching
Eligibility Criteria
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Inclusion Criteria
* \>55 yrs of age
* Mild cognitive impairment (18-26 on the MOCA)
* ability to undergo an MR
* no history of major head trauma (No head trauma/concussion with loss of consciousness)
* Speaks, reads, writes English
Exclusion Criteria
* Participating in a supervised exercise program with intent to increase fitness levels 3 days/week,
* Requires assistive ambulation
* Limited exercise capacity due to claudication; unstable angina, severe arthritis, extreme dyspnea on exertion, unstable coronary artery disease
* Class III-IV heart failure
* History of uncontrolled sustained arrhythmias, severe/symptomatic aortic or mitral stenosis, hypertrophic obstructive cardiomyopathy, severe pulmonary hypertension, active myocarditis/pericarditis, thrombophlebitis, and recent systemic/pulmonary embolus
* Resting systolic BP \>200 mmHg or resting diastolic BP \>110 mmHg
* Any unforeseen illness or disability that would preclude cognitive testing or exercise training
* One or more contraindication for MRI; cardiac pacemaker, aneurysm clip, cochlear implants, shrapnel, history of metal fragments in eyes, neurostimulators, diagnosed claustrophobia (MRI only)
* Any self-reported major psychiatric disorders requiring medical therapy (e.g. schizophrenia, bipolar disorder).
* Self-reported new diagnosis of clinical depression within 3 months of enrollment or unstable clinical depression requiring medication adjustment within 3 months of enrollment
55 Years
ALL
No
Sponsors
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Columbia University
OTHER
National Institute on Aging (NIA)
NIH
Responsible Party
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Ulf Bronas
Professor of Biobehavioral Science (in Nursing)
Principal Investigators
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Ulf G Bronas, PhD
Role: PRINCIPAL_INVESTIGATOR
Columbia University
Locations
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Columbia University
New York, New York, United States
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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2022-0311
Identifier Type: OTHER
Identifier Source: secondary_id
AAAU9751
Identifier Type: -
Identifier Source: org_study_id
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