Lesion Site and Neglect Anosognosia in Patients With Left Hemispatial Neglect
NCT ID: NCT05654350
Last Updated: 2023-02-22
Study Results
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Basic Information
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COMPLETED
78 participants
OBSERVATIONAL
2022-12-16
2023-01-21
Brief Summary
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* Was any lesion site related to a higher neglect anosognosia rate?
* Did any lesion site related to a more severe neglect anosognosia? Participants will be divided into two groups regarding the presence of anosognosia for spatial neglect.
Researchers will compare patients with and without anosognosia to see if any lesion site resulted in a higher anosognosia rate and more severe unawareness of neglect symptoms in daily life.
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Detailed Description
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In this retrospective study, the investigators will screen the medical records of our inpatient cognitive rehabilitation unit from 2011 to 2021. Patients diagnosed with left hemispatial neglect using Catherine Bergego Scale (CBS), line bisection, star cancellation, figure and shape copying, or representational drawing tests will be included in the study. Demographic and clinical data such as age, gender, weeks after stroke, stroke type (ischemic or hemorrhagic), lesion site, Brunnstrom stages, mini-mental status examination score and severities of neglect and neglect anosognosia will be noted.
Both neglect and neglect anosognosia severities will be determined using CBS. The underestimation of spatial deficits in daily living detected by parallel CBS testing will be considered as neglect anosognosia. The neglect anosognosia score will be calculated by subtracting the patient's self-assessment score from the evaluator-assigned CBS score. A difference of at least one point will be considered the presence of anosognosia. Patients will be divided into two groups with and without anosognosia according to the CBS-anosognosia score. Demographic and clinical features of patients with and without anosognosia will be compared. The correlation between neglect and neglect anosognosia scores will be examined.
The lesion site will be described by regions of interest (ROI) involvement using a semi-quantitative analyse. The association between anosognosia presence and involvement of the ROI will be analysed using the odds ratio with %95 confidence intervals. Neglect and anosognosia severities will also be compared between involvement and sparing of each ROI. Mini-mental state examination scores will be compared between the groups with and without anosognosia to address mental status, which may be a confounding factor in the evaluation of anosognosia.
Conditions
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Study Design
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CASE_CONTROL
RETROSPECTIVE
Study Groups
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Patients with neglect anosognosia
Subacute or chronic right hemispheric stroke patients with left hemispatial neglect and neglect anosognosia.
No interventions assigned to this group
Patients without neglect anosognosia
Subacute or chronic right hemispheric stroke patients with left hemispatial neglect but no neglect anosognosia.
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* Having a subacute or chronic right hemispheric supratentorial stroke
* Having left hemispatial neglect
Exclusion Criteria
* Lesions involving the left hemisphere and/or brainstem and/or cerebellum
* Having other neurological conditions such as traumatic brain injury, central nervous system neoplasm, neurodegenerative or neuropsychiatric diseases
* Presence of severe cognitive impairment in the mini-mental state examination scale (\<10 points)
* Lack of brain imaging data
* Having visual problems and psychiatric disorders hindering neglect and anosognosia evaluation
18 Years
ALL
No
Sponsors
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Gazi University
OTHER
Responsible Party
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Levent Karataş
Principal Investigator, MD
Principal Investigators
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Gülçin Kaymak Karataş, MD
Role: PRINCIPAL_INVESTIGATOR
Gazi University Faculty of Medicine
Levent Karataş, MD
Role: PRINCIPAL_INVESTIGATOR
Gazi University Faculty of Medicine
Locations
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Gazi University Hospital, Department of Physical Medicine and Rehabilitation
Ankara, , Turkey (Türkiye)
Countries
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References
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Langer KG, Bogousslavsky J. The Merging Tracks of Anosognosia and Neglect. Eur Neurol. 2020;83(4):438-446. doi: 10.1159/000510397. Epub 2020 Sep 14.
Jehkonen M, Laihosalo M, Kettunen J. Anosognosia after stroke: assessment, occurrence, subtypes and impact on functional outcome reviewed. Acta Neurol Scand. 2006 Nov;114(5):293-306. doi: 10.1111/j.1600-0404.2006.00723.x.
Heilman KM. Possible mechanisms of anosognosia of hemiplegia. Cortex. 2014 Dec;61:30-42. doi: 10.1016/j.cortex.2014.06.007. Epub 2014 Jun 19.
Vossel S, Weiss PH, Eschenbeck P, Saliger J, Karbe H, Fink GR. The neural basis of anosognosia for spatial neglect after stroke. Stroke. 2012 Jul;43(7):1954-6. doi: 10.1161/STROKEAHA.112.657288. Epub 2012 May 24.
Rousseaux M, Allart E, Bernati T, Saj A. Anatomical and psychometric relationships of behavioral neglect in daily living. Neuropsychologia. 2015 Apr;70:64-70. doi: 10.1016/j.neuropsychologia.2015.02.011. Epub 2015 Feb 10.
Karnath HO, Baier B. Right insula for our sense of limb ownership and self-awareness of actions. Brain Struct Funct. 2010 Jun;214(5-6):411-7. doi: 10.1007/s00429-010-0250-4. Epub 2010 May 29.
Laporta-Hoyos O, Fiori S, Pannek K, Ballester-Plane J, Leiva D, Reid LB, Pagnozzi AM, Vazquez E, Delgado I, Macaya A, Pueyo R, Boyd RN. Brain lesion scores obtained using a simple semi-quantitative scale from MR imaging are associated with motor function, communication and cognition in dyskinetic cerebral palsy. Neuroimage Clin. 2018 Jun 14;19:892-900. doi: 10.1016/j.nicl.2018.06.015. eCollection 2018.
Pia L, Neppi-Modona M, Ricci R, Berti A. The anatomy of anosognosia for hemiplegia: a meta-analysis. Cortex. 2004 Apr;40(2):367-77. doi: 10.1016/s0010-9452(08)70131-x.
Other Identifiers
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Anosognosia and lesion site
Identifier Type: -
Identifier Source: org_study_id
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