Long-term Follow-up Study in Patients Previously Treated With a Mustang Bio CAR-T Cell Investigational Product.

NCT ID: NCT05645744

Last Updated: 2024-07-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

TERMINATED

Total Enrollment

3 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-09-29

Study Completion Date

2024-04-12

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

A long-term follow-up study to assess safety and efficacy in patients previously treated with Mustang Bio chimeric antigen receptor (CAR)-T cell investigational products.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Non-interventional, multi-center, long-term follow-up study of subjects previously treated with a Mustang Bio CAR-T cell investigational product in a Mustang Bio sponsored clinical study. Subjects who enroll will be monitored for a total of up to 15 years from the time of their last investigational product infusion.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN) Chronic Lymphocytic Leukemia in Relapse Small Lymphocytic Lymphoma, Relapsed Waldenstrom's Macroglobulinemia Recurrent Follicular B-cell Non-Hodgkin's Lymphoma B-cell Lymphoma Refractory Mantle Cell Lymphoma Recurrent Hairy Cell Leukemia Diffuse Large B Cell Lymphoma Waldenstrom's Macroglobulinemia Refractory Mantle Cell Lymphoma Refractory

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

OTHER

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Prior MB-102 CAR-T cell investigational product.

Patients previously treated with MB-102 CAR-T cell investigational product.

Prior MB-102 CAR-T cell investigational product.

Intervention Type BIOLOGICAL

No investigational product will be administered.

Prior MB-106 CAR-T cell investigational product.

Patients previously treated with MB-106 CAR-T cell investigational product.

Prior MB-106 CAR-T cell investigational product.

Intervention Type BIOLOGICAL

No investigational product will be administered.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Prior MB-102 CAR-T cell investigational product.

No investigational product will be administered.

Intervention Type BIOLOGICAL

Prior MB-106 CAR-T cell investigational product.

No investigational product will be administered.

Intervention Type BIOLOGICAL

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Patients previously treated with a Mustang Bio CAR-T cell investigational product in a prior Mustang Bio sponsored clinical study.
* Patient has provided signed and dated informed consent.

Exclusion Criteria

* None. All patients who have received prior treatment with Mustang Bio CAR-T cell investigational product in a Mustang Bio sponsored clinical study are eligible for this long-term follow up (LTFU) study.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Mustang Bio

INDUSTRY

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Bruce Dezube, M.D.

Role: STUDY_DIRECTOR

Mustang Bio

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

UC Irvine Health - Chao Family Comprehensive Cancer Center

Orange, California, United States

Site Status

Massachusetts General Hospital

Boston, Massachusetts, United States

Site Status

University of Rochester Medical Center

Rochester, New York, United States

Site Status

Cleveland Clinic

Cleveland, Ohio, United States

Site Status

Fred Hutchinson Cancer Center

Seattle, Washington, United States

Site Status

Countries

Review the countries where the study has at least one active or historical site.

United States

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

MB100-OBS-001

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.