A Clinical Study Exploring CT1194C in Patients With Relapsed/Refractory B-cell Non-Hodgkin Lymphoma

NCT ID: NCT07068906

Last Updated: 2025-07-16

Basic Information

• Recruitment Status: NOT_YET_RECRUITING
• Clinical Phase: PHASE1
• Total Enrollment: 27 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2025-07-15
• Study Completion Date: 2027-06-30

Brief Summary

A Clinical Study to Investigate the Safety, Efficacy, and Cellular Metabolism of CT1194C CAR-T Cell therapy, in Patients with Relapsed/Refractory B-Cell NonHodgkin Lymphoma.

Detailed Description

This is a single-arm, open-label, dose exploratory clinical study to evaluate the safety, efficacy, cellular pharmacokinetics, and pharmacodynamics of CT1194C cells in patients with B-NHL. It is planned to enroll 3-27 participants.

Conditions

B-Cell Non-Hodgkin Lymphoma

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

CAR-T cells chimeric antigen receptor T cells

Group Type: EXPERIMENTAL

CAR-T cells chimenric antigen receptor T cells

Intervention Type: DRUG

CT1194C cells infusion

Interventions

CAR-T cells chimenric antigen receptor T cells

CT1194C cells infusion

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

1. Participants must voluntarily sign the informed consent form (ICF) and must be willing and be able to adhere to the study visit schedule and other protocol requirements

2. 18-75 years old;

3. Histologically or cytologically confirmed B-NHL;

4. Previously received at least 2 lines of systemic therapy;

5. Intolerance to last treatment, or have progressed on or after the last treatment and currently require therapy;

6. There are measurable target lesions;

7. Expected survival > 12 weeks;

8. Eastern Cooperative Oncology Group (ECOG) score 0-1;

9. Female participants of childbearing potential must have a negative pregnancy test at screening and prior to receiving preconditioning therapy。Both male and Female are willing to use a highly effective and reliable method of contraception for 1 year after receiving study treatment and are absolutely prohibited from donating sperm donation or eggs for 1 year after receiving study treatment infusion during the study;

Exclusion Criteria

1. Pregnant or lactating women;

2. Has HIV, syphilis infection, active hepatitis B virus infection (HBsAg positive and HBV-DNA above the detection limit), or active hepatitis C virus infection (HCV antibody and HCV-DNA positive);

3. Has any current uncontrolled active infection, including but not limited to participants with active tuberculosis (investigator 's judgment);

4. Participants' toxicities caused by previous treatment did not recover to Common Terminology Criteria for Adverse Events (CTCAE) ≤ Grade 1, except alopecia and other events that are judged tolerable by the investigator;

5. Has received treatment for the disease within 14 days before informed consent, including but not limited to cytotoxic therapy, monoclonal antibodies or ADCs, targeted therapy, radiotherapy, epigenetic therapy, or investigational agents, or invasive investigational medical devices within 14 days before informed consent. If the radiation field covers ≤ 5% of the bone marrow reserve, the participant is eligible regardless of the end date of radiotherapy;

6. Systemic glucocorticoids equivalent to > 15 mg/day prednisone within 7 days prior to informed consent, with the exception of topical glucocorticoids;

7. Vaccination with live attenuated vaccines, inactivate vaccines or RNA vaccines within 4 weeks prior to informed consent;

8. Participants who are allergic or intolerant to preconditioning drugs, tocilizumab, or have other previous history of severe allergy such as anaphylactic shock;

9. Patients with any heart disease in the 6 months prior to screening;

10. Oxygen saturation < 92%,;

11. Presence of a second primary malignancy requiring treatment or not in complete remission within the past 2 years;

12. Major surgery within 2 weeks before informed consent or planned during the study period or within 4 weeks after giving study treatment (excluding local anesthesia such as cataract);

13. Participants are unable or unwilling to comply with the requirements of the study protocol or are otherwise unsuitable for participating in this clinical study in the investigator 's assessment;

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 75 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Institute of Hematology & Blood Diseases Hospital, China

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

China Institute of Hematology and Blood Diseases Hospital

Tianjin, , China

Countries

China

Central Contacts

Liang Huang

Role: CONTACT

huangliang@ihcams.ac.cn

13971600192

Facility Contacts

Liang Huang

Role: primary

huangliang@ihcams.ac.cn

13971600192

Other Identifiers

IIT2025069

Identifier Type: -

Identifier Source: org_study_id