Dried Purple Laver (Nori) as a Food Source of Vitamin B12 in Vegetarians
NCT ID: NCT05614960
Last Updated: 2023-06-01
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
30 participants
INTERVENTIONAL
2022-11-07
2023-03-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
PREVENTION
NONE
Study Groups
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2.4μg vitamin B12
Participants need to consume 4 sheets (5g) of dried purple laver (Nori) daily for 4 weeks.
Dried purple laver (Nori)
Dried purple laver (Nori) that has been test to have bioactivity vitamin B12 will be given for intervention groups.
4μg vitamin B12
Participants need to consume 7 sheets (8g) of dried purple laver (Nori) daily for 4 weeks.
Dried purple laver (Nori)
Dried purple laver (Nori) that has been test to have bioactivity vitamin B12 will be given for intervention groups.
Control
No intervention
No interventions assigned to this group
Interventions
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Dried purple laver (Nori)
Dried purple laver (Nori) that has been test to have bioactivity vitamin B12 will be given for intervention groups.
Eligibility Criteria
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Inclusion Criteria
* Duration of the vegetarian diet: at least 1 year
* Aged 20-60 years old
* Have not taken vitamin B12 or folate supplement within 1 year
* Willing to adhere to study intervention and be tested for vitamin B12 related biomarkers.
* Familiar with LINE application on smartphone
Exclusion Criteria
* Hyperthyroidism
* Previous adverse reaction to nori
* Have taken antacid or metformin in the past 1 week
* Alcoholic and not willing to abstinence from alcoholic beverages
20 Years
60 Years
ALL
Yes
Sponsors
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Fu Jen Catholic University
OTHER
Responsible Party
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Tina Hsueh-Ting Chiu
Associate Professor
Principal Investigators
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Tina Hsueh-Ting Chiu, PhD
Role: PRINCIPAL_INVESTIGATOR
Fu-Jen Catholic University, Department of Nutritional Science
Locations
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Department of Nutritional Science, Fu-Jen Catholic University
New Taipei City, , Taiwan
Countries
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References
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Chiu THT, Kao YC, Wang LY, Chang HR, Lin CL. A Dietitian-Led Vegan Program May Improve GlycA, and Other Novel and Traditional Cardiometabolic Risk Factors in Patients With Dyslipidemia: A Pilot Study. Front Nutr. 2022 Mar 24;9:807810. doi: 10.3389/fnut.2022.807810. eCollection 2022.
Takenaka S, Sugiyama S, Ebara S, Miyamoto E, Abe K, Tamura Y, Watanabe F, Tsuyama S, Nakano Y. Feeding dried purple laver (nori) to vitamin B12-deficient rats significantly improves vitamin B12 status. Br J Nutr. 2001 Jun;85(6):699-703. doi: 10.1079/bjn2001352.
Suzuki H. Serum vitamin B12 levels in young vegans who eat brown rice. J Nutr Sci Vitaminol (Tokyo). 1995 Dec;41(6):587-94. doi: 10.3177/jnsv.41.587.
Schwarz J, Dschietzig T, Schwarz J, Dura A, Nelle E, Watanabe F, Wintgens KF, Reich M, Armbruster FP. The influence of a whole food vegan diet with Nori algae and wild mushrooms on selected blood parameters. Clin Lab. 2014;60(12):2039-50. doi: 10.7754/clin.lab.2014.140527.
Rauma AL, Torronen R, Hanninen O, Mykkanen H. Vitamin B-12 status of long-term adherents of a strict uncooked vegan diet ("living food diet") is compromised. J Nutr. 1995 Oct;125(10):2511-5. doi: 10.1093/jn/125.10.2511.
Watanabe F, Yabuta Y, Bito T, Teng F. Vitamin B(1)(2)-containing plant food sources for vegetarians. Nutrients. 2014 May 5;6(5):1861-73. doi: 10.3390/nu6051861.
Rizzo G, Lagana AS, Rapisarda AM, La Ferrera GM, Buscema M, Rossetti P, Nigro A, Muscia V, Valenti G, Sapia F, Sarpietro G, Zigarelli M, Vitale SG. Vitamin B12 among Vegetarians: Status, Assessment and Supplementation. Nutrients. 2016 Nov 29;8(12):767. doi: 10.3390/nu8120767.
Huang QN, Watanabe F, Koseki K, He RE, Lee HL, Chiu THT. Effect of roasted purple laver (nori) on vitamin B12 nutritional status of vegetarians: a dose-response trial. Eur J Nutr. 2024 Dec;63(8):3269-3279. doi: 10.1007/s00394-024-03505-9. Epub 2024 Oct 1.
Other Identifiers
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FuJenCU
Identifier Type: -
Identifier Source: org_study_id
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