Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
1000 participants
OBSERVATIONAL
2019-08-01
2022-11-30
Brief Summary
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Detailed Description
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There are many methods for detecting niacin, but so far with no reports for large population. Dr. Shi Hongjun from West Lake University used the most sensitive QTRAP 6500+ liquid chromatography tandem mass spectrometer to accurately quantify the concentration of NAD, nicotinamide, niacin and other niacin metabolites in plasma and have optimized the detection process, which would be applicated in this study.
At the same time, studies have shown that pregnant women generally have multiple vitamin deficiency during pregnancy, including plasma thiamine, vitamin A, vitamin B6, vitamin B12 and vitamin D. Therefore, in addition to detecting plasma niacin, this study will also examine the plasma levels of the remaining multivitamins to further explore the impact of nutritional deficiencies on the probability of recurrent miscarriage.
Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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recurrent abortion
women of childbearing age who have spontaneous abortion within 20 weeks of pregnancy for 2 or more consecutive times.
Detection of niacin and other vitamins in plasma
Detection of niacin and other vitamins in plasma
normal pregnancy history
Women of childbearing age who had a normal pregnancy history and are not in pregnancy status now.
Detection of niacin and other vitamins in plasma
Detection of niacin and other vitamins in plasma
general population
Women of childbearing age in general examination.
Detection of niacin and other vitamins in plasma
Detection of niacin and other vitamins in plasma
Interventions
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Detection of niacin and other vitamins in plasma
Detection of niacin and other vitamins in plasma
Eligibility Criteria
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Inclusion Criteria
Control group: 1) Women of childbearing age who had a normal pregnancy history and are not in pregnancy status now. 2) Women of childbearing age in general examination.
Exclusion Criteria
1. Both husband and wife have been diagnosed with chromosomal abnormalities or fetal chorionic chromosomal abnormalities;
2. The patient has been diagnosed with uterine abnormalities;
3. vaginal bacterial infection or chlamydial infection;
4. antiphospholipid antibody syndrome;
5. Other immune system diseases (hypothyroidism, PCOS, hyperprolactinemia);
6. ovarian function decline (FSH\>10mIU/ml);
7. Cervical insufficiency5.3 Exit criteria:
After being selected, the researcher was withdrawn due to various considerations.
35 Years
FEMALE
Yes
Sponsors
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Peking Union Medical College Hospital
OTHER
Responsible Party
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Principal Investigators
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Qi Yu, Professor
Role: STUDY_DIRECTOR
Peking Union Medical College Hospital
Locations
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Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences
Beijing, Beijing Municipality, China
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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yuqi2019
Identifier Type: -
Identifier Source: org_study_id
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