Endothelial Glycocalyx Damage in Brain Death Organ Donors

NCT ID: NCT05609123

Last Updated: 2025-03-27

Basic Information

• Recruitment Status: ACTIVE_NOT_RECRUITING
• Total Enrollment: 100 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2022-01-01
• Study Completion Date: 2025-12-31

Brief Summary

The study aims the assessment of endothelial glycocalyx (EG) degradation in deceased organ donors. There is a lack of organs for the transplantation program. By the description of the EG status, we can open room for organ optimization before transplantation and improve the organ function after transplantation in marginal donors.

Conditions

Brain Damage Due to Hypoxia; Organ Donors; Organ Transplant Failure or Rejection

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Study Groups

Brain dead organ donors

Patients with clinically proven bain death were assigned to the paraclinical confirmatory investigation of the brain death and subsequently accepted into the transplantation program.

Endothelial glycocalyx damage assessment

Intervention Type: DIAGNOSTIC_TEST

Degradation products of endothelial glycocalyx will be assessed in the blood and urine.

Interventions

Endothelial glycocalyx damage assessment

Degradation products of endothelial glycocalyx will be assessed in the blood and urine.

Intervention Type: DIAGNOSTIC_TEST

Eligibility Criteria

Inclusion Criteria

• patients in critical condition declared as brain dead by clinical examination

Exclusion Criteria

• N/A

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

University Hospital Hradec Kralove

OTHER

Sponsor Role: lead

Responsible Party

David Astapenko, MD, PhD

Deputy Head for Science and Research

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

University Hospital Hradec Kralove

Hradec Králové, , Czechia

Countries

Czechia

Other Identifiers

CooperatioUK_DBD_GCX

Identifier Type: -

Identifier Source: org_study_id