The Transcriptomic Study of Thai Patients With Atopic Dermatitis by Tape Strips
NCT ID: NCT05598762
Last Updated: 2022-11-04
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
100 participants
INTERVENTIONAL
2022-12-31
2024-07-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
BASIC_SCIENCE
NONE
Study Groups
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Children with mild atopic dermatitis
* age 1-8 years old
* mild degree of atopic dermatitis
Tape strips
Tape strip is a minimally invasive method that captures the stratum corneum. It is use to identify skin biomarkers in atopic dermatitis.
Children with moderate-severe atopic dermatitis
* age 1-8 years old
* moderate or severe degree of atopic dermatitis
Tape strips
Tape strip is a minimally invasive method that captures the stratum corneum. It is use to identify skin biomarkers in atopic dermatitis.
Children with food allergy and moderate-severe atopic dermatitis
* age 1-8 years old
* moderate or severe degree of atopic dermatitis
* IgE mediated food allergy
Tape strips
Tape strip is a minimally invasive method that captures the stratum corneum. It is use to identify skin biomarkers in atopic dermatitis.
Adult with atopic dermatitis
* age 18-60 years old
* mild-severe atopic dermatitis
Tape strips
Tape strip is a minimally invasive method that captures the stratum corneum. It is use to identify skin biomarkers in atopic dermatitis.
Healthy
* age 1-60 years old
* no history of atopic diseases
Tape strips
Tape strip is a minimally invasive method that captures the stratum corneum. It is use to identify skin biomarkers in atopic dermatitis.
Healthy with Asthma
* age 1-8 years old
* doctor diagnosed asthma
* no history of chronic or chronic relapsing eczema
Tape strips
Tape strip is a minimally invasive method that captures the stratum corneum. It is use to identify skin biomarkers in atopic dermatitis.
Interventions
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Tape strips
Tape strip is a minimally invasive method that captures the stratum corneum. It is use to identify skin biomarkers in atopic dermatitis.
Eligibility Criteria
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Inclusion Criteria
* Children (age 1-18 years old) with moderate to severe atopic dermatitis
* Children (age 1-18 years old) with moderate to severe atopic dermatitis and food allergy
* Adult (age 18-60 years old) with atopic dermatitis
* Healthy individuals (1-60 years old)
* Patients with asthma (1-60 years old)
Exclusion Criteria
* Used systemic immunosuppressants within 4 weeks
* Used topical steroids or immunomodulators within 1 week
* Used moisturizers within 12 hours before evaluation
1 Year
60 Years
ALL
Yes
Sponsors
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Mahidol University
OTHER
Icahn School of Medicine at Mount Sinai
OTHER
Samitivej Hospital group
UNKNOWN
Queen Sirikit National Institute of Child Health
OTHER_GOV
Responsible Party
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Tassalapa Daengsuwan
Assistant Professor
Principal Investigators
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Panipak Temboonnark, MD
Role: PRINCIPAL_INVESTIGATOR
Queen Sirikit National Institute of Child Health
Locations
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Queen Sirikit National Institute of Child Health
Bangkok, , Thailand
Countries
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Central Contacts
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References
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Czarnowicki T, He H, Krueger JG, Guttman-Yassky E. Atopic dermatitis endotypes and implications for targeted therapeutics. J Allergy Clin Immunol. 2019 Jan;143(1):1-11. doi: 10.1016/j.jaci.2018.10.032.
Brunner PM, Guttman-Yassky E. Racial differences in atopic dermatitis. Ann Allergy Asthma Immunol. 2019 May;122(5):449-455. doi: 10.1016/j.anai.2018.11.015. Epub 2018 Nov 20.
Chan TC, Sanyal RD, Pavel AB, Glickman J, Zheng X, Xu H, Cho YT, Tsai TF, Wen HC, Peng X, Cueto I, Krueger JG, Guttman-Yassky E. Atopic dermatitis in Chinese patients shows TH2/TH17 skewing with psoriasiform features. J Allergy Clin Immunol. 2018 Sep;142(3):1013-1017. doi: 10.1016/j.jaci.2018.06.016. Epub 2018 Jun 28. No abstract available.
Guttman-Yassky E, Diaz A, Pavel AB, Fernandes M, Lefferdink R, Erickson T, Canter T, Rangel S, Peng X, Li R, Estrada Y, Xu H, Krueger JG, Paller AS. Use of Tape Strips to Detect Immune and Barrier Abnormalities in the Skin of Children With Early-Onset Atopic Dermatitis. JAMA Dermatol. 2019 Dec 1;155(12):1358-1370. doi: 10.1001/jamadermatol.2019.2983.
Other Identifiers
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65-007
Identifier Type: -
Identifier Source: org_study_id
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