Efficacy and Safety Trial of ALK-depot SQ Mites in Subjects With Atopic Dermatitis

NCT ID: NCT00310492

Last Updated: 2015-12-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

154 participants

Study Classification

INTERVENTIONAL

Study Start Date

2006-04-30

Study Completion Date

2009-11-30

Brief Summary

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This trial is performed to assess the efficacy and safety of ALK-depot SQ mites for treatment of atopic dermatitis

Detailed Description

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Conditions

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Atopic Dermatitis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Subcutaneous immunotherapy

Subcutaneous injections with ALK-depot SQ mites to 100,000 SQ-U

Group Type ACTIVE_COMPARATOR

subcutaneous immunotherapy

Intervention Type BIOLOGICAL

Updosing by 16 injections to 100,000 SQ-U

Subcutaneous injections

placebo injections

Group Type PLACEBO_COMPARATOR

subcutaneous immunotherapy

Intervention Type BIOLOGICAL

Updosing by 16 injections to 100,000 SQ-U

Interventions

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subcutaneous immunotherapy

Updosing by 16 injections to 100,000 SQ-U

Intervention Type BIOLOGICAL

Other Intervention Names

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ALK-depot SQ mites

Eligibility Criteria

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Inclusion Criteria

* Positive specific IgE to house dust mites
* Atopic dermatitis according to Hanifin/Rajka
* Chronic course of Atopic dermatitis
* SCORAD larger than 25 points

Exclusion Criteria

* Erythrodermia
* Syst.treatment with gcs or immunosuppressive agents in the prev.4 weeks
* History of specific immunotherapy with mites
* UV radiation
* Group 4 topical corticosteroids (European classification)
Minimum Eligible Age

18 Years

Maximum Eligible Age

55 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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ALK-Abelló A/S

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Hendrik Wolf, PhD

Role: STUDY_DIRECTOR

ALK-SCHERAX Arzneimittel GmbH

Alexander Kapp, MD, Prof.

Role: PRINCIPAL_INVESTIGATOR

Hannover Medical School

Locations

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Medizinische Hochschule Hannover, Klinik für Dermatologie und Venerologie

Hanover, , Germany

Site Status

Countries

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Germany

Other Identifiers

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SHX0556

Identifier Type: -

Identifier Source: org_study_id