Bleeding Intracerebral Hemorrhage With Early Invasive Intracranial Pressure Monitoring Trial
NCT ID: NCT05593380
Last Updated: 2025-09-08
Study Results
Results pending
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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Recruitment Status
COMPLETED
Clinical Phase
NA
Total Enrollment
193 participants
Study Classification
INTERVENTIONAL
Study Start Date
2022-11-15
Study Completion Date
2025-07-28
Brief Summary
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Spontaneous cerebral hemorrhage (SICH) is a hemorrhage caused by the rupture of a blood vessel within the brain parenchyma that is non-traumatic. Its rapid onset and dangerous condition seriously threaten human health; it accounts for about 15% of strokes and 50% of stroke-related mortality. Hunan Province is recognized as one of the high incidence areas of cerebral hemorrhage in the world; according to statistics, the direct economic loss caused by cerebral hemorrhage in Hunan Province is more than 1 billion yuan per year, which should be paid great attention. A 30-day follow-up study of large-volume cerebral hemorrhage (defined as supratentorial hemorrhage greater than 30 ml, infratentorial greater than 5 ml, and thalamus and cerebellum greater than 15 ml) found that the morbidity and mortality rate of ICH with hemorrhage of 30-60 ml was as high as 44-74%, while the morbidity and mortality rate of ICH with hemorrhage of \<30 ml was 19% and that of \>60 ml was 91%. According to studies, the occurrence of hematoma occupancy and malignant cerebral edema in large-volume cerebral hemorrhage can lead to secondary malignant intracranial pressure elevation and subsequent secondary brain injury, which are the main factors of high morbidity and mortality and poor prognosis in patients with large-volume cerebral hemorrhage. Clinical monitoring and management is the key to treatment, and despite aggressive surgical treatment and anti-brain edema therapy, a large number of patients progress to malignant brain edema disease, leading to poor outcomes. This study aims to conduct a multicenter clinical trial in China investigating the role of invasive intracranial pressure (ICP) monitoring in managing patients with large-volume supratentorial intracerebral hemorrhage. The trial will evaluate whether ICP-guided treatment protocols for cerebral edema improve patient outcomes and generate evidence to support the clinical application of invasive ICP monitoring in this patient population.
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Detailed Description
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Intracranial pressure and cerebral edema monitoring are widely employed modalities of neurological assessment in neurocritical care patients globally. However, uncertainties remain regarding the prognostic value of invasive and noninvasive intracranial pressure monitoring and cerebral edema monitoring techniques on neurological function in patients with both traumatic and non-traumatic brain injuries. Additionally, clinical practices for these modalities vary significantly in patients with extensive cerebral hemorrhage. This study aims to determine whether continuous ambulatory monitoring of intracranial pressure, administered postoperatively to patients with large-volume cerebral hemorrhage, can enhance overall prognosis by guiding adjustments in brain-specific therapeutic intensity and reducing mortality within 90 days. The study is designed as a prospective, open-label, randomized, controlled, multi-center trial with a sample size estimated based on the efficacy observed in prior research, encompassing approximately 190 cases across 15-20 clinical institutions in China experienced in treating large-volume cerebral hemorrhage. The study population consists of patients diagnosed with significant supraventricular cerebral hemorrhage (≥30 ml, based on the Coniglobus formula) via CT examination within 48 hours of symptom onset. Informed consent was obtained from patients who met the eligibility criteria. Ethical risks associated with high-volume cerebral hemorrhage were mitigated by offering surgical treatment (either open debridement flap or endoscopic hematoma removal) in accordance with established guidelines and consideration of the patients condition, the physicians judgment, and the familys preferences. Enrolled participants were randomly assigned in a 1:1 ratio to either the invasive intracranial pressure monitoring group or the imaging-clinical examination (ICE) group. All relevant research organizations and personnel will adhere to the Declaration of Helsinki and the Chinese Standards of Good Clinical Practice. This trial has received approval from the Institutional Review Board (IRB) and Ethics Committee (EC) of Xiangya Hospital, Central South University.
Conditions
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Cerebral Hemorrhage, Hypertensive
Intracranial Hypertension
Monitoring
Critical Care
Treatment Outcome
Invasive Intracranial Pressure Monitoring
Large-volume Cerebral Hemorrhage
Study Design
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Allocation Method
RANDOMIZED
Intervention Model
PARALLEL
Primary Study Purpose
TREATMENT
Blinding Strategy
SINGLE
Outcome Assessors
Study Groups
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ICP monitoring
Intracranial pressure monitoring equipment enables continuous dynamic monitoring of changes in intracranial pressure values. This technology reflects sudden shifts in intracranial pressure resulting from hemorrhage and other cranial conditions, allowing for timely adjustments in the intensity of cerebral therapeutic interventions.
Group Type
EXPERIMENTAL
Parenchymal Intracranial pressure monitor
Intervention Type
DEVICE
Treatment based on readings from Parenchymal intracranial pressure monitor.
imaging-clinical examination (ICE)
According to routine head CT imaging examinations, dynamic observations of changes in the patient's condition should be conducted. This involves closely monitoring clinical consciousness, pupil response, limb activity, and other clinical manifestations. Adjustments to the intensity of cerebral intervention should be made based on the clinical reflections of these dynamic changes.
Group Type
OTHER
Treatment based on clinical and imaging observations
Intervention Type
OTHER
Treatment based on clinical and imaging observations.
Interventions
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Parenchymal Intracranial pressure monitor
Treatment based on readings from Parenchymal intracranial pressure monitor.
Intervention Type
DEVICE
Treatment based on clinical and imaging observations
Treatment based on clinical and imaging observations.
Intervention Type
OTHER
Other Intervention Names
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Integra Life Sciences Camino Intracranial Monitor
Eligibility Criteria
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Inclusion Criteria
1. Age ≥18 years old and Age \<80 years old.
2. Diagnosed of a supratentorial spontaneous intracerebral hemorrhage.
3. Diagnosis of supratentorial large-volume cerebral hemorrhage by CT or other imaging and meeting the diagnostic criteria for large-volume cerebral hemorrhage(hemorrhage volume ≥ 30 mL of supratentorial cerebral parenchymal hematoma volume according to the Coniglobus formula on the first CT scan at onset).
4. Participants were enrolled within 48 hours of symptom onset.
5. The family signed the informed consent.
2. Diagnosed of a supratentorial spontaneous intracerebral hemorrhage.
3. Diagnosis of supratentorial large-volume cerebral hemorrhage by CT or other imaging and meeting the diagnostic criteria for large-volume cerebral hemorrhage(hemorrhage volume ≥ 30 mL of supratentorial cerebral parenchymal hematoma volume according to the Coniglobus formula on the first CT scan at onset).
4. Participants were enrolled within 48 hours of symptom onset.
5. The family signed the informed consent.
Exclusion Criteria
1. Traumatic cerebral hemorrhage, cerebral amyloid angiopathy(CAA), secondary cerebral hemorrhage due to other specific etiologies (aneurysm, vascular malformation, smoker's disease, coagulopathy, aneurysmal stroke, vasculitis, cerebral venous thrombosis, hemorrhagic cerebral infarction, etc.)
2. The presence of fixed bilateral dilated pupils on admission, no recovery of pupils after initial dehydration treatment, and very poor survival
3. Patients with extremely unstable vital signs after admission, with extremely poor prognosis and those considered non-viable, and patients whose families have abandoned follow-up treatment
4. Patients who are pregnant or lactating.
5. Patients with bilateral temporal skin ulceration, or subcutaneous hematoma in which monitoring electrode placement cannot be implemented
6. The presence of other serious underlying diseases (intractable hypoxemia and circulatory failure with cardiopulmonary insufficiency that is difficult to correct by treatment, severe abnormal coagulation, severely reduced platelets, severe hepatic and renal insufficiency, combined neurodegenerative diseases, psychiatric diseases, autoimmune diseases, malignant tumors, thyroid diseases, etc.)
7. The patient is agitated, coughing or choking too frequently, unable to be sedated or has difficulty in handling.
8. Those with mRS score \> 2 before this onset.
9. Individuals unable to complete the follow-up phase of this trial due to psychiatric, cognitive, or emotional conditions;
10. Family members decline to provide informed consent.
Exit criteria:
1. Acute onset of other life-threatening illnesses identified as the primary cause of mortality;
2. Participants who voluntarily withdraw from the study before completion;
3. Participants deemed unsuitable for the trial's monitoring protocol post-enrollment;
4. Participants requiring a modification of the treatment plan post-enrollment due to medical reasons, resulting in compromised monitoring feasibility or significant deviations in monitoring accuracy that undermine the integrity of the final analysis.
Elimination criteria：
1. Participants who failed to record any data post-enrollment;
2. Participants who did not receive per-protocol treatment post-enrollment, were discharged within 72 hours, and had their families voluntarily withdraw informed consent;
3. Participants whose invasive intracranial pressure (ICP) monitoring probes shifted and were not promptly reinserted or calibrated, leading to excessive data errors precluding analysis;
4. Participants not receiving the invasive intracranial pressure (ICP) monitoring module according to their assigned group.
2. The presence of fixed bilateral dilated pupils on admission, no recovery of pupils after initial dehydration treatment, and very poor survival
3. Patients with extremely unstable vital signs after admission, with extremely poor prognosis and those considered non-viable, and patients whose families have abandoned follow-up treatment
4. Patients who are pregnant or lactating.
5. Patients with bilateral temporal skin ulceration, or subcutaneous hematoma in which monitoring electrode placement cannot be implemented
6. The presence of other serious underlying diseases (intractable hypoxemia and circulatory failure with cardiopulmonary insufficiency that is difficult to correct by treatment, severe abnormal coagulation, severely reduced platelets, severe hepatic and renal insufficiency, combined neurodegenerative diseases, psychiatric diseases, autoimmune diseases, malignant tumors, thyroid diseases, etc.)
7. The patient is agitated, coughing or choking too frequently, unable to be sedated or has difficulty in handling.
8. Those with mRS score \> 2 before this onset.
9. Individuals unable to complete the follow-up phase of this trial due to psychiatric, cognitive, or emotional conditions;
10. Family members decline to provide informed consent.
Exit criteria:
1. Acute onset of other life-threatening illnesses identified as the primary cause of mortality;
2. Participants who voluntarily withdraw from the study before completion;
3. Participants deemed unsuitable for the trial's monitoring protocol post-enrollment;
4. Participants requiring a modification of the treatment plan post-enrollment due to medical reasons, resulting in compromised monitoring feasibility or significant deviations in monitoring accuracy that undermine the integrity of the final analysis.
Elimination criteria：
1. Participants who failed to record any data post-enrollment;
2. Participants who did not receive per-protocol treatment post-enrollment, were discharged within 72 hours, and had their families voluntarily withdraw informed consent;
3. Participants whose invasive intracranial pressure (ICP) monitoring probes shifted and were not promptly reinserted or calibrated, leading to excessive data errors precluding analysis;
4. Participants not receiving the invasive intracranial pressure (ICP) monitoring module according to their assigned group.
Minimum Eligible Age
18 Years
Maximum Eligible Age
80 Years
Eligible Sex
ALL
Accepts Healthy Volunteers
No
Sponsors
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Xiangya Hospital of Central South University
OTHER
Sponsor Role
lead
Responsible Party
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Responsibility Role
SPONSOR
Principal Investigators
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Zhang Le, PhD
Role: PRINCIPAL_INVESTIGATOR
Department of Neurology，Xiangya Hospital, Central South University
Locations
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The First People's Hospital of Changde City (Changde Hospital, Xiangya School of Medicine, Central South University)
Changde, Hunan, China
Site Status
Changsha Central Hospital
Changsha, Hunan, China
Site Status
The Fourth Hospital of Changsha
Changsha, Hunan, China
Site Status
Xiangya Hospital, Central South University
Changsha, Hunan, China
Site Status
Changsha Hospital of Traditional Chinese Medicine (Changsha Eighth Hospital)
Changsha, Hunan, China
Site Status
Chenzhou First People's Hospital
Chenzhou, Hunan, China
Site Status
Hunan University of Medicine General Hospital
Huaihua, Hunan, China
Site Status
Xiangxi Tujia and Miao Autonomous Prefecture People's Hospital, First Affiliated Hospital of Jishou University School of Medicine
Jishou, Hunan, China
Site Status
The Central Hospital of Shaoyang
Shaoyang, Hunan, China
Site Status
The Central Hospital of Xiangtan, The Affiliated Hospital of Hunan University
Xiangtan, Hunan, China
Site Status
The Central Hospital of Yongzhou
Yongzhou, Hunan, China
Site Status
Yueyang Central Hospital
Yueyang, Hunan, China
Site Status
Zhangjiajie People's Hospital
Zhangjiajie, Hunan, China
Site Status
Zhuzhou Central Hospital
Zhuzhou, Hunan, China
Site Status
Jiangxi Provincial People's Hospital
Nanchang, Jiangxi, China
Site Status
Chengdu Fifth Pepole's Hospital
Chengdu, Sichuan, China
Site Status
Xuanwu Hospital Capital Medical University
Beijing, , China
Site Status
Countries
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China
References
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GBD 2016 Causes of Death Collaborators. Global, regional, and national age-sex specific mortality for 264 causes of death, 1980-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet. 2017 Sep 16;390(10100):1151-1210. doi: 10.1016/S0140-6736(17)32152-9.
Reference Type
BACKGROUND
Bao YH, Liang YM, Gao GY, Pan YH, Luo QZ, Jiang JY. Bilateral decompressive craniectomy for patients with malignant diffuse brain swelling after severe traumatic brain injury: a 37-case study. J Neurotrauma. 2010 Feb;27(2):341-7. doi: 10.1089/neu.2009.1040.
Reference Type
BACKGROUND
Carney N, Totten AM, O'Reilly C, Ullman JS, Hawryluk GW, Bell MJ, Bratton SL, Chesnut R, Harris OA, Kissoon N, Rubiano AM, Shutter L, Tasker RC, Vavilala MS, Wilberger J, Wright DW, Ghajar J. Guidelines for the Management of Severe Traumatic Brain Injury, Fourth Edition. Neurosurgery. 2017 Jan 1;80(1):6-15. doi: 10.1227/NEU.0000000000001432.
Reference Type
BACKGROUND
Chesnut RM, Temkin N, Carney N, Dikmen S, Rondina C, Videtta W, Petroni G, Lujan S, Pridgeon J, Barber J, Machamer J, Chaddock K, Celix JM, Cherner M, Hendrix T; Global Neurotrauma Research Group. A trial of intracranial-pressure monitoring in traumatic brain injury. N Engl J Med. 2012 Dec 27;367(26):2471-81. doi: 10.1056/NEJMoa1207363. Epub 2012 Dec 12.
Reference Type
BACKGROUND
Raj R, Bendel S, Reinikainen M, Hoppu S, Laitio R, Ala-Kokko T, Curtze S, Skrifvars MB. Costs, outcome and cost-effectiveness of neurocritical care: a multi-center observational study. Crit Care. 2018 Sep 20;22(1):225. doi: 10.1186/s13054-018-2151-5.
Reference Type
BACKGROUND
Kumar G, Kalita J, Misra UK. Raised intracranial pressure in acute viral encephalitis. Clin Neurol Neurosurg. 2009 Jun;111(5):399-406. doi: 10.1016/j.clineuro.2009.03.004. Epub 2009 Apr 15.
Reference Type
BACKGROUND
Czosnyka M, Pickard JD. Monitoring and interpretation of intracranial pressure. J Neurol Neurosurg Psychiatry. 2004 Jun;75(6):813-21. doi: 10.1136/jnnp.2003.033126.
Reference Type
BACKGROUND
Treggiari MM, Schutz N, Yanez ND, Romand JA. Role of intracranial pressure values and patterns in predicting outcome in traumatic brain injury: a systematic review. Neurocrit Care. 2007;6(2):104-12. doi: 10.1007/s12028-007-0012-1.
Reference Type
BACKGROUND
Helbok R, Olson DM, Le Roux PD, Vespa P; Participants in the International Multidisciplinary Consensus Conference on Multimodality Monitoring. Intracranial pressure and cerebral perfusion pressure monitoring in non-TBI patients: special considerations. Neurocrit Care. 2014 Dec;21 Suppl 2:S85-94. doi: 10.1007/s12028-014-0040-6.
Reference Type
BACKGROUND
Simma B, Burger R, Falk M, Sacher P, Fanconi S. A prospective, randomized, and controlled study of fluid management in children with severe head injury: lactated Ringer's solution versus hypertonic saline. Crit Care Med. 1998 Jul;26(7):1265-70. doi: 10.1097/00003246-199807000-00032.
Reference Type
BACKGROUND
O'Sullivan MG, Statham PF, Jones PA, Miller JD, Dearden NM, Piper IR, Anderson SI, Housley A, Andrews PJ, Midgley S, et al. Role of intracranial pressure monitoring in severely head-injured patients without signs of intracranial hypertension on initial computerized tomography. J Neurosurg. 1994 Jan;80(1):46-50. doi: 10.3171/jns.1994.80.1.0046.
Reference Type
BACKGROUND
Hiler M, Czosnyka M, Hutchinson P, Balestreri M, Smielewski P, Matta B, Pickard JD. Predictive value of initial computerized tomography scan, intracranial pressure, and state of autoregulation in patients with traumatic brain injury. J Neurosurg. 2006 May;104(5):731-7. doi: 10.3171/jns.2006.104.5.731.
Reference Type
BACKGROUND
Ropper AH. Management of raised intracranial pressure and hyperosmolar therapy. Pract Neurol. 2014 Jun;14(3):152-8. doi: 10.1136/practneurol-2014-000811. Epub 2014 Jan 30.
Reference Type
BACKGROUND
Bales JW, Bonow RH, Buckley RT, Barber J, Temkin N, Chesnut RM. Primary External Ventricular Drainage Catheter Versus Intraparenchymal ICP Monitoring: Outcome Analysis. Neurocrit Care. 2019 Aug;31(1):11-21. doi: 10.1007/s12028-019-00712-9.
Reference Type
BACKGROUND
Aiolfi A, Khor D, Cho J, Benjamin E, Inaba K, Demetriades D. Intracranial pressure monitoring in severe blunt head trauma: does the type of monitoring device matter? J Neurosurg. 2018 Mar;128(3):828-833. doi: 10.3171/2016.11.JNS162198. Epub 2017 May 26.
Reference Type
BACKGROUND
Liu H, Wang W, Cheng F, Yuan Q, Yang J, Hu J, Ren G. External Ventricular Drains versus Intraparenchymal Intracranial Pressure Monitors in Traumatic Brain Injury: A Prospective Observational Study. World Neurosurg. 2015 May;83(5):794-800. doi: 10.1016/j.wneu.2014.12.040. Epub 2014 Dec 23.
Reference Type
BACKGROUND
Tavakoli S, Peitz G, Ares W, Hafeez S, Grandhi R. Complications of invasive intracranial pressure monitoring devices in neurocritical care. Neurosurg Focus. 2017 Nov;43(5):E6. doi: 10.3171/2017.8.FOCUS17450.
Reference Type
BACKGROUND
LANGFITT TW, WEINSTEIN JD, KASSELL NF, SIMEONE FA. TRANSMISSION OF INCREASED INTRACRANIAL PRESSURE. I. WITHIN THE CRANIOSPINAL AXIS. J Neurosurg. 1964 Nov;21:989-97. doi: 10.3171/jns.1964.21.11.0989. No abstract available.
Reference Type
BACKGROUND
Lenfeldt N, Koskinen LO, Bergenheim AT, Malm J, Eklund A. CSF pressure assessed by lumbar puncture agrees with intracranial pressure. Neurology. 2007 Jan 9;68(2):155-8. doi: 10.1212/01.wnl.0000250270.54587.71.
Reference Type
BACKGROUND
Andrews PJ, Citerio G. Intracranial pressure. Part one: historical overview and basic concepts. Intensive Care Med. 2004 Sep;30(9):1730-3. doi: 10.1007/s00134-004-2376-4. Epub 2004 Jul 9. No abstract available.
Reference Type
BACKGROUND
Miller C, Armonda R; Participants in the International Multi-disciplinary Consensus Conference on Multimodality Monitoring. Monitoring of cerebral blood flow and ischemia in the critically ill. Neurocrit Care. 2014 Dec;21 Suppl 2:S121-8. doi: 10.1007/s12028-014-0021-9.
Reference Type
BACKGROUND
Nag DS, Sahu S, Swain A, Kant S. Intracranial pressure monitoring: Gold standard and recent innovations. World J Clin Cases. 2019 Jul 6;7(13):1535-1553. doi: 10.12998/wjcc.v7.i13.1535.
Reference Type
BACKGROUND
Fernando SM, Tran A, Cheng W, Rochwerg B, Taljaard M, Kyeremanteng K, English SW, Sekhon MS, Griesdale DEG, Dowlatshahi D, McCredie VA, Wijdicks EFM, Almenawer SA, Inaba K, Rajajee V, Perry JJ. Diagnosis of elevated intracranial pressure in critically ill adults: systematic review and meta-analysis. BMJ. 2019 Jul 24;366:l4225. doi: 10.1136/bmj.l4225.
Reference Type
BACKGROUND
Dubourg J, Javouhey E, Geeraerts T, Messerer M, Kassai B. Ultrasonography of optic nerve sheath diameter for detection of raised intracranial pressure: a systematic review and meta-analysis. Intensive Care Med. 2011 Jul;37(7):1059-68. doi: 10.1007/s00134-011-2224-2. Epub 2011 Apr 20.
Reference Type
BACKGROUND
Reid A, Marchbanks RJ, Burge DM, Martin AM, Bateman DE, Pickard JD, Brightwell AP. The relationship between intracranial pressure and tympanic membrane displacement. Br J Audiol. 1990 Apr;24(2):123-9. doi: 10.3109/03005369009077853.
Reference Type
BACKGROUND
Lou JH, Wang J, Liu LX, He LY, Yang H, Dong WW. Measurement of brain edema by noninvasive cerebral electrical impedance in patients with massive hemispheric cerebral infarction. Eur Neurol. 2012;68(6):350-7. doi: 10.1159/000342030. Epub 2012 Oct 23.
Reference Type
BACKGROUND
He LY, Wang J, Luo Y, Dong WW, Liu LX. Application of non-invasive cerebral electrical impedance measurement on brain edema in patients with cerebral infarction. Neurol Res. 2010 Sep;32(7):770-4. doi: 10.1179/016164109X12478302362572. Epub 2009 Sep 1.
Reference Type
BACKGROUND
Makarenko S, Griesdale DE, Gooderham P, Sekhon MS. Multimodal neuromonitoring for traumatic brain injury: A shift towards individualized therapy. J Clin Neurosci. 2016 Apr;26:8-13. doi: 10.1016/j.jocn.2015.05.065. Epub 2016 Jan 2.
Reference Type
BACKGROUND
Dallagiacoma S, Robba C, Graziano F, Rebora P, Hemphill JC, Galimberti S, Citerio G; SYNAPSE-ICU Investigators. Intracranial Pressure Monitoring in Patients With Spontaneous Intracerebral Hemorrhage: Insights From the SYNAPSE-ICU Study. Neurology. 2022 Jul 12;99(2):e98-e108. doi: 10.1212/WNL.0000000000200568. Epub 2022 May 4.
Reference Type
BACKGROUND
Related Links
Access external resources that provide additional context or updates about the study.
http://rs.yiigle.com/CN112137201709/972019.htm
Chinese Expert Consensus on Monitoring and Treatment of Spontaneous Large Volume Cerebral Hemorrhage
https://kns.cnki.net/kcms/detail/detail.aspx?dbcode=CJFD&dbname=CJFDZHYX&filename=ZHCS201708016&uniplatform=NZKPT&v=OTLqMwQkzJB53apyj50gXP473ZTeWwtlkohToiHUng0eDpXbcih6qYcsaWiYBAnL
An applied research on non-invasive and dynamic monitor of cerebral edema in patients after craniotomy
https://kns.cnki.net/kcms/detail/detail.aspx?dbcode=CMFD&dbname=CMFD2009&filename=2009064300.nh&uniplatform=NZKPT&v=AOpPQzQDMl-VJZ8H-KWRPhyaLhowckOyadDTtb6G6erEL1sKBd34MTJGx9FpqcTE
Trunk subdivision bioelectrical impedance analysis of body composition
https://kns.cnki.net/kcms/detail/detail.aspx?dbcode=CJFD&dbname=CJFD2001&filename=YXWZ200101009&uniplatform=NZKPT&v=lVYC_AMvNqB4o4X1tQ7L22y6HQGl7QDAAN-b_0AR5SZ-brjNXnUXclpt3iEgQyuQ
Disturbance method of electric current field and its application in impedance imaging
https://kns.cnki.net/kcms/detail/detail.aspx?dbcode=CJFD&dbname=CJFD2003&filename=ZHYX200306008&uniplatform=NZKPT&v=CAr8b2wwr3b7L8O8NxFHAC2KFXMdVrX51LitXvBPRsgejq8CVaMuVgwKAK8QInbv
Noninvasive monitoring of hypertensive intracerebral hemorrhage and perihematomal tissue edema
https://kns.cnki.net/kcms/detail/detail.aspx?dbcode=CJFD&dbname=CJFD2007&filename=ZHSJ200706007&uniplatform=NZKPT&v=rxlfgEeP_kUAcTBIbfqYfRPuuVNEEzR8G9G4CfqzrNblOUph8Lyhw1BDdd6rlNpd
Application of noninvasive cerebral electrical impedance measurement on brain edema in patients with intracerebral hemorrhage
https://kns.cnki.net/kcms/detail/detail.aspx?dbcode=CMFD&dbname=CMFD2010&filename=2010015764.nh&uniplatform=NZKPT&v=DZRsncyRWA-kDLE22rWY3SxXwHUbJSHInOPpMy4EgV2S9hjIL3368SpaJS0wzZ_N
A new method of noninvasive brain-edema monitoring in patients with intracranial tumor: cerebral electrical impedance measurement
https://kns.cnki.net/kcms/detail/detail.aspx?dbcode=CJFD&dbname=CJFD2011&filename=LXYB201103016&uniplatform=NZKPT&v=pBUGsByuDjfeeKsmumQdEjnXla7Ybu3xGwem1DHVPYsNvIFvVN6_9ZbGPG2T4Gyd
An applied research on non-invasive and dynamic monitor of cerebral edema in patients after craniotomy
https://kns.cnki.net/kcms/detail/detail.aspx?dbcode=CJFD&dbname=CJFD2012&filename=ZWQX201208005&uniplatform=NZKPT&v=qSCtlduJ1C_UjPQ_SJCYNecS2t62VxY_NmKKhHtDKo_LVmcFT8FYVnJJ2JKxP-cz
Application of continuous intracranial pressure monitoring in hypertensive cerebral hemorrhge
Other Identifiers
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2018FY100900
Identifier Type: OTHER
Identifier Source: secondary_id
sjnkzhangle
Identifier Type: -
Identifier Source: org_study_id
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